The utilization of natural deep eutectic solvent composition in tocotrienol and tocopherol extraction from crude palm oil and its acylglycerol products

Rizki, Ilmi Fadhilah; Panjaitan, Frisda Rimbun; Mulyono, Manda Edy; Bajra, Brahmani Dewa

doi:10.1016/j.jfca.2022.104818

Cited by 5 publications

(3 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The vitamin E from palm oil is known as the tocotrienol-rich fraction (TRF), which contains tocotrienols (70%) and tocopherols (30%). 13,14 Several researchers have reported on the ability of TRF to modulate the host immune system. To the best of our knowledge, no studies investigated a dose-response curve using TRF supplementation and its impact on the host immune system.…”

Section: Discussionmentioning

confidence: 99%

“…The vitamin E from palm oil, known as the tocotrienol-rich fraction (TRF), is a mixture of tocotrienols (70%) and tocopherols (30%). 13,14 Several clinical and experimental model-based studies have shown that tocotrienols have several biological activities such as antioxidant, 15,16 lipid-lowering, 17,18 immune-enhancing, [19][20][21] anticancer, [22][23][24] neuroprotective, [25][26][27] and anti-diabetic. 28,29 Tocotrienols may cause these effects by acting at the epigenome, genome or protein levels.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Single-centre, randomised clinical trial of the immunomodulatory mechanisms of daily supplementation of palm tocotrienol-rich fraction in healthy human volunteers following influenza vaccination

Radhakrishnan,

Ahmad,

Selvaduray

et al. 2024

F1000Res

View full text Add to dashboard Cite

Background Vitamin E from palm oil, known as the tocotrienol-rich fraction (TRF), has been shown to have immune-enhancing activity. To date, only one dose of TRF (400 mg daily) has been tested in a clinical trial. The proposed study will evaluate the immune-enhancing activity effects of lower doses (200, 100 and 50 mg) in a clinical trial using an influenza vaccine as the immunological challenge. Methods A single-centre, randomised, parallel, double-blinded, placebo-controlled clinical trial with balance allocation involving five arms will be conducted. The healthy volunteers recruited will be randomly assigned to one of the arms, and they will be asked to take the respective supplements (400 mg, 200 mg, 100 mg, 50 mg of TRF or placebo) daily with their dinner. The volunteers will receive the influenza vaccine after four weeks. They will be asked to return to the study site four weeks later. A blood sample will be taken for the study at baseline, four and eight weeks. Primary outcome measures will be antibody levels to influenza, blood leucocyte profile and cytokine production. Secondary outcomes will be correlating plasma vitamin E levels with immune responses, plasma proteins and gene expression patterns. The findings from this study will be published in relevant peer-reviewed journals and presented at relevant national and international scientific meetings. Conclusions The recent world events have created the awareness of having a healthy and functional immune system. Nutrition plays an important role in helping the immune system to function optimally. This study will show the effects of lower doses of TRF in boosting the immune response of healthy individuals and also elucidate the mechanisms through which TRF exerts its immune-enhancing effects. Clinical trial registration Australian New Zealand Clinical Trials Registry (ANZCTR) [ACTRN12622000844741] dated 15 June 2022. Protocol version 2

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Single-centre, randomised clinical trial of the immunomodulatory mechanisms of daily supplementation of palm tocotrienol-rich fraction in healthy human volunteers following influenza vaccination

Radhakrishnan,

Ahmad,

Selvaduray

et al. 2024

F1000Res

View full text Add to dashboard Cite

show abstract

“…Gambar 4. Skema pemisahan vitamin E dari CPO dan ekstraksi isomer-isomernya Sumber:Rizki et al, 2022 …”

unclassified

Mengenal Tokotrienol: Biosintesis, Ekstraksi, Dan Potensinya

Setiowati

2023

war

View full text Add to dashboard Cite

Vitamin E telah dikenal sebagai sumber antioksidan yang banyak ditemukan pada berbagai sayur dan buah. Secara teknis, vitamin E merupakan istilah umum untuk menyebut senyawa larut lemak yang dapat berupa tokoferol, plastokromanol, tokomonoenol, tokodienol, maupun tokotrienol. Secara kolektif senyawa-senyawa ini disebut sebagai tokokromanol atau tokol. Ada kalanya tokoferol digunakan untuk meyebut vitamin E secara umum. Di sisi lain, tokotrienol merupakan bagian dari keluarga vitamin E yang memiliki karakteristik vitamin E, namun dengan aktivitas yang lebih kuat dibanding tokoferol. Keunikan tokotrienol menjadikannya banyak dilirik sebagai salah satu fitofarmaka untuk berbagai keperluan kesehatan dan perawatan (farmasetikal, nutrasetikal, dan kosmesetikal). Sayangnya, sebaran tokotrienol sangat terbatas dan tidak ditemukan dalam jumlah yang signifikan pada banyak tanaman. Berita baiknya, kelapa sawit merupakan sumber minyak nabati dengan kandungan tokotrienol terbesar. Review ini berfokus pada biosintesis tokotrienol dan tokoferol pada tanaman serta metode-metode yang dikembangkan sebagai upaya mengekstraksi tokotrienol dari minyak mentah kelapa sawit Crude Palm Oil (CPO).

show abstract

Impact of Different Natural Deep Eutectic Solvents on Dissolution Behaviour and Eutectogel Structure of Jackfruit Seed Starch

2023

View full text Add to dashboard Cite

The utilization of natural deep eutectic solvent composition in tocotrienol and tocopherol extraction from crude palm oil and its acylglycerol products

Cited by 5 publications

References 28 publications

Single-centre, randomised clinical trial of the immunomodulatory mechanisms of daily supplementation of palm tocotrienol-rich fraction in healthy human volunteers following influenza vaccination

Single-centre, randomised clinical trial of the immunomodulatory mechanisms of daily supplementation of palm tocotrienol-rich fraction in healthy human volunteers following influenza vaccination

Mengenal Tokotrienol: Biosintesis, Ekstraksi, Dan Potensinya

Impact of Different Natural Deep Eutectic Solvents on Dissolution Behaviour and Eutectogel Structure of Jackfruit Seed Starch

Contact Info

Product

Resources

About