The UV-vis absorption spectrum of the flavonol quercetin in methanolic solution: A theoretical investigation

Andrade-Filho, Tarciso; Ribeiro, Tamires C.S.; Nero, Jordan Del

doi:10.1140/epje/i2009-10485-7

Cited by 21 publications

(12 citation statements)

References 45 publications

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“…The peak at 610 nm is ascribed to SiQDs emitting red photoluminescence, which is quenched slightly in dual‐loaded PEG–PLA nanoparticles. The UV‐vis absorption spectra provide valuable information about the encapsulation of quercetin in PEG–PLA nanoparticles 35. The quercetin loaded PEG–PLA nanoparticles and SiQDs only PEG–PLA nanoparticles have distinct absorption spectra.…”

Section: Resultsmentioning

confidence: 99%

Co‐encapsulation of Biodegradable Nanoparticles with Silicon Quantum Dots and Quercetin for Monitored Delivery

Wang

Bao

Ahire

et al. 2012

Adv Healthcare Materials

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Polymer nanoparticles have emerged as a promising new strategy for the efficient delivery of drugs. They have several advantages when used as drug carriers, such as high stability, high capacity, improvement of drug bioavailability, as well as allowing for sustained drug release. Quercetin has therapeutic potential as an anticancer drug, but has poor solubility and low bioavailability. In this study it is shown that co-encapsulation of quercetin and fluorescent Silicon quantum dots (SiQDs) in poly (ethylene glycol)-block-polylactide (PEG-PLA) nanoparticles can be used for simultaneous in vitro imaging and to improve the biocompatibility of quercetin. Fluorescent imaging with SiQDs can provide a new concept to monitor the delivery of anti-cancer drugs. The nanoparticles are synthesized based on the double emulsion method and are extensively characterized and assayed for cytotoxicity in vitro. HepG2 cells are incubated with quercetin and SiQDs dual-loaded PEG-PLA nanoparticles, resulting in a red fluorescent staining which can be detected with a confocal microscope. PEG-PLA nanoparticle encapsulated quercetin suppresses human hepatoma HepG2 cell proliferation more effectively than the free-standing form. In addition, nanoparticle-encapsulated quercetin significantly inhibits hydrogen peroxide-induced DNA damage in HepG2 cells. These data show that nanocapsulated quercetin possesses the potential bioactivity to reduce the drug dosage frequency, as well as increase patient compliance. The combination of polymeric nanoparticles and semiconductor quantum dots can allow monitoring of delivery, improve aqueous solubility, and enhance biocompatibility. Such nanoparticulated systems could shape the future of drug delivery.

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Section: Resultsmentioning

confidence: 99%

Co‐encapsulation of Biodegradable Nanoparticles with Silicon Quantum Dots and Quercetin for Monitored Delivery

Wang

Bao

Ahire

et al. 2012

Adv Healthcare Materials

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“…Up to now, many studies on photo-induced refractive index change under irradiation from UV lamps concentrated on PMMA containing either photochemically active dopants or residual monomer have been reported [1]. Further investigation in this direction is warranted as it may provide a practical solution to realize low-cost fabrication of polymeric devices [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Low-intensity UV effects on optical constants of PMMA film

Rashidian

Dorranian

2014

J Theor Appl Phys

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Effects of low-intensity UV treatment on the optical constants of red BS dye-doped polymethyl methacrylate (PMMA) film including refractive index, extinction coefficient, real and imaginary parts of dielectric constant, band gap energy, Urbach energy, and refractive index dispersion parameters are measured and calculated. Changes in optical constants mainly occurred in the UV-VIS range. Red BS dye, which is used as a UV absorber impurity in PMMA films, generated another energy band gap which was increased by UV treatment. Although some of the optical constants of PMMA are not changed noticeably by the treatment in this low range of UV radiation, our results confirm that polymeric changes such as chain scission and depolymerization can directly affect the optical constants of PMMA.

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“…the most studied of the dietary flavonoids and one of the most abundant plant-derived polyphenols widely consumed in a human diet [17][18][19][20][21][22][23][24][25][26]. Quercetin ( Figure 1), containing the 3',4'-dihydroxy structure of the B ring (catechol B ring), is known to possess a high antioxidant ability expressed through scavenging of free radicals (a "chain-breaking role").…”

mentioning

confidence: 99%

Quercetin oxidation by horseradish peroxidase: The effect of UV-B irradiation

Savić

Stanojevic

Marković

et al. 2013

Hem Ind

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Horseradish peroxidase (HRP), a highly-investigated member of the peroxidase family has been known, among many other biological activities, to catalyze the oxidation of flavonoids and phenolic substrates overall, including quercetin. On the other hand, quercetin is very well known for its antioxidant activities, which in the case of UV external radiation is exibited partly in a preventive manner since it is an excellent UV-absorber. Therefore the aim of this investigation is to study quercetin oxidation by HRP in phosphate buffer under the conditions of UV-stress, i.e. continuous, prolonged UV-B irradiation. The results show that while UV-B irradiation affects the activity of HRP, and the overal rate of quercetin oxidation by HRP, it probably has very little effect on it for longer UV-B-irradiation periods (>30 min). [Acknowledgements. This work was supported by the Ministry of Education and Science of the Republic of Serbia under Project No.TR-34012 and OI-172044

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The UV-vis absorption spectrum of the flavonol quercetin in methanolic solution: A theoretical investigation

Cited by 21 publications

References 45 publications

Co‐encapsulation of Biodegradable Nanoparticles with Silicon Quantum Dots and Quercetin for Monitored Delivery

Co‐encapsulation of Biodegradable Nanoparticles with Silicon Quantum Dots and Quercetin for Monitored Delivery

Low-intensity UV effects on optical constants of PMMA film

Quercetin oxidation by horseradish peroxidase: The effect of UV-B irradiation

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