The vagus nerve mediates cardio-respiratory coupling that changes with metabolic demand in a temperate nototheniod fish

Campbell, Hamish A.; Egginton, Stuart

doi:10.1242/jeb.003822

Cited by 18 publications

(13 citation statements)

References 28 publications

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“…Multi-strand Teflon-coated stainless steel wire (A-M Systems, USA), used for electrocardiogram (ECG) recording electrodes to measure f H , and an intraperitoneal catheter, used for drug delivery, were implanted as previously described (Campbell and Egginton, 2007;Campbell et al, 2006). The fish were allowed to recover in fresh aerated water then placed into a metabolic recording chamber, with the ECG leads exiting through the top of the chamber, and were not disturbed or fed for 96 h before initial readings were taken.…”

Section: Methodsmentioning

confidence: 99%

Cardiorespiratory responses in an Antarctic fish suggest limited capacity for thermal acclimation

Egginton

Campbell

2016

Journal of Experimental Biology

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Section: Methodsmentioning

confidence: 99%

Cardiorespiratory responses in an Antarctic fish suggest limited capacity for thermal acclimation

Egginton

Campbell

2016

Journal of Experimental Biology

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“…The study proposed that if stimulation of the vagus nerve were to be repeated, before the last inhibition response ended then sustained inhibition may be maintained (Zagon and Kemeny 2000). Animal studies have shown cardiorespiratory coupling ceases after bilateral vagotomy, suggesting that cardiorespiratory synchronization is mediated by the vagus nerve, which imparts parasympathetic control (Campbell and Egginton 2007;Dick et al 2009;Topchiy et al 2011). In addition, schizophrenic patients exhibit decreased levels of cardiorespiratory synchronization, which indicates decreased vagal modulation and inhibition in the brainstem (Peupelmann et al 2009).…”

Section: Possible Role Of Membrane Potential In Cardiorespiratory Modmentioning

confidence: 99%

Self-Regulation of Breathing as a Primary Treatment for Anxiety

Jerath¹,

Crawford²,

Barnes

et al. 2015

Appl Psychophysiol Biofeedback

199

125

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Understanding the autonomic nervous system and homeostatic changes associated with emotions remains a major challenge for neuroscientists and a fundamental prerequisite to treat anxiety, stress, and emotional disorders. Based on recent publications, the inter-relationship between respiration and emotions and the influence of respiration on autonomic changes, and subsequent widespread membrane potential changes resulting from changes in homeostasis are discussed. We hypothesize that reversing homeostatic alterations with meditation and breathing techniques rather than targeting neurotransmitters with medication may be a superior method to address the whole body changes that occur in stress, anxiety, and depression. Detrimental effects of stress, negative emotions, and sympathetic dominance of the autonomic nervous system have been shown to be counteracted by different forms of meditation, relaxation, and breathing techniques. We propose that these breathing techniques could be used as firstline and supplemental treatments for stress, anxiety, depression, and some emotional disorders.

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“…Unrestrained and normoxic fish exhibited long periods of CRS, which is under vagal control, as it can be abolished by cardiac vagotomy or injection of atropine (Taylor, 1992). Injection of neural tracers to identify VPNs (Axelsson et al, 1992); Antarctic fish 3, Paranotothenia angustata (Campbell and Egginton, 2007); sea bass, Dicentrarchus labrax (Iversen et al, 2010); skipjack tuna, Katsuwonus pelamis, and yellowfin tuna, Thunnus albacores (Keen et al, 1995); African lungfish, Protopterus annectens (Sandblom et al, 2010). Amphibians: axolotl, Ambystoma mexicanum ; African clawed toad, Xenopus laevis (Taylor and Ihmied, 1995); bullfrog, Lithobates catesbeianus (Taylor et al, 2012); pepper frog, Leptodactylus labyrinthicus (M.R.S., A.S.A.…”

Section: Chondrichthyes (Cartilaginous Fishes -The Elasmobranchs)mentioning

confidence: 99%

The phylogeny and ontogeny of autonomic control of the heart and cardiorespiratory interactions in vertebrates

Taylor

Leite

Sartori

et al. 2014

Journal of Experimental Biology

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Heart rate in vertebrates is controlled by activity in the autonomic nervous system. In spontaneously active or experimentally prepared animals, inhibitory parasympathetic control is predominant and is responsible for instantaneous changes in heart rate, such as occur at the first air breath following a period of apnoea in discontinuous breathers like inactive reptiles or species that surface to air breathe after a period of submersion. Parasympathetic control, exerted via fast-conducting, myelinated efferent fibres in the vagus nerve, is also responsible for beat-to-beat changes in heart rate such as the high frequency components observed in spectral analysis of heart rate variability. These include respiratory modulation of the heartbeat that can generate cardiorespiratory synchrony in fish and respiratory sinus arrhythmia in mammals. Both may increase the effectiveness of respiratory gas exchange. Although the central interactions generating respiratory modulation of the heartbeat seem to be highly conserved through vertebrate phylogeny, they are different in kind and location, and in most species are as yet little understood. The heart in vertebrate embryos possesses both muscarinic cholinergic and β-adrenergic receptors very early in development. Adrenergic control by circulating catecholamines seems important throughout development. However, innervation of the cardiac receptors is delayed and first evidence of a functional cholinergic tonus on the heart, exerted via the vagus nerve, is often seen shortly before or immediately after hatching or birth, suggesting that it may be coordinated with the onset of central respiratory rhythmicity and subsequent breathing.

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The vagus nerve mediates cardio-respiratory coupling that changes with metabolic demand in a temperate nototheniod fish

Abstract: -1 , respectively; P<0.05) but abolished all HRV and CRC, although M O 2 was significantly less for a given f H and f V compared to intact fish. Thus, P. angustata exhibits vagally mediated CRC, and the association between f H and f V varies according to oxygen demand.

Cited by 18 publications

References 28 publications

Cardiorespiratory responses in an Antarctic fish suggest limited capacity for thermal acclimation

Cardiorespiratory responses in an Antarctic fish suggest limited capacity for thermal acclimation

Self-Regulation of Breathing as a Primary Treatment for Anxiety

The phylogeny and ontogeny of autonomic control of the heart and cardiorespiratory interactions in vertebrates

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