The Validity of Gynecological Ultrasonography

Loutradis, Dimitris; Antsaklis, Aris; Creatsas, G.; Hatzakis, Angelos; Kanakas, N.; Gougoulakis, A.; Michalas, S.; Aravantinos, D.

doi:10.1159/000293299

Cited by 23 publications

(17 citation statements)

References 4 publications

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“…Ultrasonography has high sensitivity (99%) and specificity (91%) relative to histologic evidence (39,40). To maximize the specificity of UL classification, pelvic exam cases (n = 502) were treated as noncases because these diagnoses could have represented other gynecologic pathology (41).…”

Section: Assessment Of Outcomementioning

confidence: 99%

Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata

Wise¹,

Radin²,

Palmer³

et al. 2011

The American Journal of Clinical Nutrition

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Background: US black women have higher rates of uterine leiomyomata (UL) and lower intakes of fruit and vegetables than do white women. Whether fruit and vegetable intake is associated with UL in black women has not been studied. Objective: We assessed the association of dietary intake of fruit, vegetables, carotenoids, folate, fiber, and vitamins A, C, and E with UL in the Black Women's Health Study. Design: In this prospective cohort study, we followed 22,583 premenopausal women for incident UL (1997UL ( -2009). Diet was estimated by using food-frequency questionnaires in 1995 and 2001. Cox regression was used to derive incidence rate ratios (IRRs) and 95% CIs for the association between each dietary variable (in quintiles) and UL. Results: There were 6627 incident cases of UL diagnosed by ultrasonography (n = 4346) or surgery (n = 2281). Fruit and vegetable intake was inversely associated with UL (4 compared with ,1 serving/d; IRR: 0.90; 95% CI: 0.82, 0.98; P-trend = 0.03). The association was stronger for fruit (2 servings/d compared with ,2 servings/wk; IRR: 0.89; 95% CI: 0.81, 0.98; P-trend = 0.07) than for vegetables (2 servings/d compared with ,4 servings/wk: IRR: 0.97; 95% CI: 0.89, 1.05; P-trend = 0.51). Citrus fruit intake was inversely associated with UL (3 servings/wk compared with ,1 serving/mo: IRR: 0.92; 95% CI: 0.86, 1.00; P-trend = 0.01). The inverse association for dietary vitamin A (upper compared with lower quintiles: IRR: 0.89; 95% CI: 0.83, 0.97; P-trend = 0.01) appeared to be driven by preformed vitamin A (animal sources), not provitamin A (fruit and vegetable sources). UL was not materially associated with dietary intake of vitamins C and E, folate, fiber, or any of the carotenoids, including lycopene. Conclusion: These data suggest a reduced risk of UL among women with a greater dietary intake of fruit and preformed vitamin A.

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Section: Assessment Of Outcomementioning

confidence: 99%

Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata

Wise¹,

Radin²,

Palmer³

et al. 2011

The American Journal of Clinical Nutrition

View full text Add to dashboard Cite

show abstract

“…This is the same definition as employed by the Nurses' Health Study II, a prospective study with similar methodology to the BWHS (Marshall et al, 1997). Ultrasound has high sensitivity (99%) and specificity (91%) relative to histological evidence (Loutradis et al, 1990;Dueholm et al, 2002).…”

Section: Assessment Of Outcomementioning

confidence: 99%

“…Women with diagnoses confirmed only by pelvic exam (n ¼ 394) were treated as non-cases in primary analyses, because their diagnoses may have represented other pathology (Loutradis et al, 1990). Since their diagnosis may have influenced a change in lifestyle factors, their exposure information was not updated beyond the time of diagnosis.…”

Section: Assessment Of Outcomementioning

confidence: 99%

Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study

Wise

Palmer

Harlow³

et al. 2004

Human Reproduction

117

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BACKGROUND: Tobacco, alcohol and caffeine consumption may influence risk of uterine leiomyomata via changes in ovarian function or hormone metabolism. METHODS: We prospectively assessed the relation of these exposures to risk of self-reported uterine leiomyomata in the Black Women's Health Study. From 1997 to 2001, we followed 21 885 premenopausal women with intact uteri and no prior myoma diagnosis. Cox regression models were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (CIs). RESULTS: During 73 426 person-years of follow-up, 2177 incident cases of uterine leiomyomata confirmed by ultrasound (n 5 1920) or hysterectomy (n 5 257) were reported. Cigarette smoking was not associated with risk of uterine leiomyomata. Risk was positively associated with years of alcohol consumption and current consumption of alcohol, particularly beer. Relative to non-drinkers, multivariate IRRs for beer consumption of <1, 1 -6 and 71 drinks/week were 1.11 (95% CI 0.98-1.27), 1.18 (95% CI 1.00-1.40) and 1.57 (95% CI 1.17-2.11), respectively. Heavy coffee and caffeine consumption were not associated with risk overall, but IRRs were increased among women aged <35 years. CON-CLUSIONS: In US black women, risk of uterine leiomyomata was positively associated with current consumption of alcohol, particularly beer. Cigarette smoking and caffeine consumption were unrelated to risk overall.

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“…Ultrasound is the clinical standard used to confirm UL diagnoses (3) and it has high sensitivity (99%) and specificity (91%) relative to histologic evidence (29,30). Every two years, beginning in 1999, women reported whether they had been diagnosed with "uterine fibroids," the calendar year of first diagnosis, and whether their diagnosis was confirmed by ultrasound or surgery.…”

Section: Assessment Of Uterine Leiomyomatamentioning

confidence: 99%

Polymorphisms in vitamin D-related genes and risk of uterine leiomyomata

Wise¹,

Ruiz-Narvaez²,

Rosenberg³

et al. 2013

Fertility and Sterility

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Objective-To investigate UL incidence in relation to polymorphisms in genes involved in vitamin D metabolism and skin pigmentation. Rates of uterine leiomyomata (UL) are 2-3 times higher in African Americans than European Americans. Recent studies suggest that vitamin D deficiency is associated with an increased risk of UL.Design-Nested case-control study. Setting-BlackWomen's Health Study, a prospective cohort study of African American women. Patient(s)-2,232premenopausal women diagnosed with UL confirmed by ultrasound or surgery during 1997-2011 (cases) and 2,432 premenopausal women never diagnosed with UL through 2011 (controls). Intervention-None.Main outcome measure-Self-reported UL. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between each polymorphism and UL, controlling for age, geographic region, and ancestry.Results-Three of twelve polymorphisms were associated with UL at the nominal significance level: rs4944957 and rs12800438 near DHCR7, and rs6058017 in ASIP. After correction for multiple hypothesis testing, two SNPs remained significantly associated with UL (rs12800438 and rs6058017). Compared with the AA genotype for rs12800438 (correlated with higher serum 25(OH)D levels), ORs were 1.09 (95% CI: 0.92, 1.29) and 1.23 (95% CI: 1.03, 1.47) for the GA and GG genotypes, respectively. Compared with the AA genotype for rs6058017 (correlated with higher serum 25(OH)D levels), ORs were 1.01 (95% CI: 0.83, 1.22) and 1.18 (95% CI: 0.97, 1.44) for the GA and GG genotypes, respectively. Conclusions-Our data support the hypothesis that vitamin D deficiency is involved in UL etiology.

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The Validity of Gynecological Ultrasonography

Cited by 23 publications

References 4 publications

Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata

Intake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata

Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women's Health Study

Polymorphisms in vitamin D-related genes and risk of uterine leiomyomata

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