The validity of health-related quality of life questionnaires in bronchiectasis: a systematic review and meta-analysis

Spinou, Arietta; Fragkos, Konstantinos C.; Lee, Kai Kong; Elston, Caroline; Siegert, Richard J.; Loebinger, Michael R.; Wilson, Robert; Garrod, Rachel; Birring, Surinder S.

doi:10.1136/thoraxjnl-2015-207315

Cited by 53 publications

(64 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition patient monitoring should include assessment of symptoms and the impact that these have on health status. This may be best achieved using a validated tool, of which there are many, 339 including tools specifically for bronchiectasis such as the QOL-B. 340 Systematic review has demonstrated that these tools may assess components of health status in bronchiectasis not measured using other outcomes.…”

Section: Section 15mentioning

confidence: 99%

“…340 Systematic review has demonstrated that these tools may assess components of health status in bronchiectasis not measured using other outcomes. 339 Routine monitoring of quality of life may not be needed in all cases but should be considered when higher cost interventions are planned. The optimal tool for monitoring treatment effects has however yet to be determined in bronchiectasis.…”

Section: Section 15mentioning

confidence: 99%

See 1 more Smart Citation

British Thoracic Society Guideline for bronchiectasis in adults

Hill

Sullivan

Chalmers

et al. 2018

Thorax

Self Cite

375

348

View full text Add to dashboard Cite

Section: Section 15mentioning

confidence: 99%

Section: Section 15mentioning

confidence: 99%

British Thoracic Society Guideline for bronchiectasis in adults

Hill

Sullivan

Chalmers

et al. 2018

Thorax

Self Cite

375

348

View full text Add to dashboard Cite

“…In adults, the St George’s Respiratory Questionnaire (SGRQ) and the Leicester cough questionnaire have been commonly used to assess QOL in patients with respiratory disease, other than asthma (9). …”

Section: Tools Used To Assess Qolmentioning

confidence: 99%

“…It consists of 50 questions grouped into 3 domains: symptoms, activity, and impact (11). In a recent systematic review of QOL questionnaires in patients with bronchiectasis, there was strong correlation with subjective symptoms but a weak correlation with objective assessments such as FEV 1 , radiological scoring, and exercise capacity (9). The SGRQ has also been used to assess QOL in children with bronchiectasis as young as 8 years old (12).…”

Section: Tools Used To Assess Qolmentioning

confidence: 99%

Review: Quality of Life in Children with Non-cystic Fibrosis Bronchiectasis

Nathan

Bruyne

et al. 2017

Front. Pediatr.

View full text Add to dashboard Cite

Non-cystic fibrosis bronchiectasis (NCFB) has gained renewed interest, due to its increasing health-care burden. Annual mortality statistics in England and Wales showed that under 1,000 people die from bronchiectasis each year, and this number is increasing by 3% yearly. Unfortunately, there is a severe lack of well-powered, randomized controlled trials to guide clinicians how to manage NCFB effectively. Quality-of-life (QOL) measures in NCFB are an important aspect of clinical care that has not been studied well. Commonly used disease-specific questionnaires in children with NCFB are the St George’s Respiratory Questionnaire, Short Form-36, the Leicester Cough Questionnaire, and the Parent Cough-Specific Quality of Life questionnaire (PC-QOL). Of these, only the PC-QOL can be used in young children, as it is a parent-proxy questionnaire. We reviewed pediatric studies looking at QOL in children with NCFB and cystic fibrosis. All types of airway clearance techniques appear to be safe and have no significant benefit over each other. Number of exacerbations and hospitalizations correlated with QOL scores, while symptom subscales correlated with lung function, worse QOL, frequent antibiotic requirements, and duration of regular follow-up in only one study. There was a correlation between QOL and age of diagnosis in children with primary ciliary dyskinesia. Other studies have shown no relationship between QOL scores and etiology of NCFB as well as CT changes. As for treatments, oral azithromycin and yoga have demonstrated some improvement in QOL scores. In conclusion, more studies are required to accurately determine important factors contributing to QOL.

show abstract

“…Further, it should be capable of changing to a clinically significant degree (i.e. a degree noticeable to the patient) after the administration of a specific therapy, or after relevant changes in the patient's circumstances [5]. Even the best questionnaire is useless, however, if nobody uses it, so another extremely important prerequisite is simplicity in terms of construction, handling and interpretation.…”

mentioning

confidence: 99%

Health-related quality of life questionnaires in bronchiectasis: the simplest way to quantify complexity

Olveira

Martínez‐García

2017

Eur Respir J

View full text Add to dashboard Cite

The human mind is probably the most complex machine in the known universe. Billions of neuronal interconnections lead each individual to respond differently to a specific stimulus, but this response can quickly alter, and it can also be modulated by interaction between the individual's environment and the genetic load that he or she has inherited. Any precise quantification of all this information is still beyond our capabilities, but a concerted effort is underway to increase the number of objective measurements that could provide us with data about the severity and activity of diseases and bring us closer, sooner or later, to what has become known as personalised medicine [1]. Nevertheless, none of the objective measurements currently available are ideal for analysing the overall impact of a disease. The key questions in this respect are: How does each individual experience the disease, not merely from a physical viewpoint but also in psychological, social and spiritual terms? What factors modulate this response? How do these vary over time? Severity, activity and impact are three different dimensions of a disease and therefore they should never be confused. At present, a disease's impact on an individual is evaluated by means of health-related quality of life questionnaires [2], which are the best tools available for gleaning the maximum information about the complexities of such an impact while simplifying it as far as possible. This has led most regulatory bodies to insist on the inclusion of health-related quality of life as one of the main outcomes of clinical trials evaluating different therapeutic measures [3,4].

show abstract

The validity of health-related quality of life questionnaires in bronchiectasis: a systematic review and meta-analysis

Cited by 53 publications

References 36 publications

British Thoracic Society Guideline for bronchiectasis in adults

British Thoracic Society Guideline for bronchiectasis in adults

Review: Quality of Life in Children with Non-cystic Fibrosis Bronchiectasis

Health-related quality of life questionnaires in bronchiectasis: the simplest way to quantify complexity

Contact Info

Product

Resources

About