The Validity of Salivary microRNAs ( hsa - miR - 200a , hsamiR - 125a and hsa - miR - 93 ) as Oral Squamous Cell Carcinoma Biomarker

Mudhir, Shaimaa H.; Al-Jubouri, Raja H.; Majeed, Ban A. Abdul

doi:10.12816/0015228

JBCD

2014

DOI: 10.12816/0015228

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The Validity of Salivary microRNAs ( hsa - miR - 200a , hsamiR - 125a and hsa - miR - 93 ) as Oral Squamous Cell Carcinoma Biomarker

Shaimaa H. Mudhir¹,

Raja H. Al-Jubouri²,

Ban A. Abdul Majeed³

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Expression of miRNAs (146a and 155) in human peri-implant tissue affected by peri-implantitis: a case control study

Hamed,

Abdulbaqi

2024

BMC Oral Health

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Background In literature, the levels of miRNA-146a and miRNA-155 are increased in periodontitis. Limited data are available regarding the expression of miRNA-146a and miR-NA-155 in diseased human peri-implant tissue. Therefore, the objective of this study was to explore the expression of miRNA-146a and miRNA-155 in human gingival peri-implant tissue affected by peri-implantitis. Methods After recording the clinical parameters, human peri-implant pocket tissues were harvested from sites diagnosed with peri-implantitis (n = 15 cases) in addition to healthy peri-implant sulcus tissues (n = 15 controls). The levels of miRNA-146a and miRNA-155 were assessed using real-time qPCR. Results Cases exhibited a significantly higher mean expression of miRNA-155 (5.2-fold increase) and miRNA-146a (2.8-fold increase) than controls. MiRNA-155 and miRNA-146a demonstrated an appropriate sensitivity (87.5% and 87.5%, respectively) and specificity (73.3% and 66.7%, respectively) in discriminating cases from controls. A moderate correlation (r = 0.544, p = 0.029) was found between miRNA-155 and miRNA-146a levels in the case group. Conclusions The expressions of miRNA-146a and miR-NA-155 are different between healthy and peri-implantitis affected tissues. Both miRNAs might potentially able to discriminate healthy from peri-implantitis affected tissues.

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Expression of miRNAs (146a and 155) in human peri-implant tissue affected by peri-implantitis: a case control study

Hamed,

Abdulbaqi

2024

BMC Oral Health

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Identification of common salivary miRNA in oral lichen planus and oral squamous cell carcinoma: systematic review and meta-analysis

Koopaie,

Akhbari,

Fatahzadeh

et al. 2024

BMC Oral Health

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Salivary Epigenetic Biomarkers in Head and Neck Squamous Cell Carcinomas

et al. 2016

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The early detection of head and neck squamous cell carcinoma (HNSCC) continues to be a challenge to the clinician. Saliva as a diagnostic medium carries significant advantages including its close proximity to the region of interest, ease of collection and noninvasive nature. While the identification of biomarkers continues to carry significant diagnostic and prognostic utility in HNSCC, epigenetic alterations present a novel opportunity to serve this purpose. With the developments of novel and innovative technologies, epigenetic alterations are now emerging as attractive candidates in HNSCC. As such, this review will focus on two commonly aberrant epigenetic alterations: DNA methylation and microRNA expression in HNSCC and their potential clinical utility. Identification and validation of these salivary epigenetic biomarkers would not only enable early diagnosis but will also facilitate in the clinical management.

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The Validity of Salivary microRNAs ( hsa - miR - 200a , hsamiR - 125a and hsa - miR - 93 ) as Oral Squamous Cell Carcinoma Biomarker

Cited by 3 publications

References 0 publications

Expression of miRNAs (146a and 155) in human peri-implant tissue affected by peri-implantitis: a case control study

Expression of miRNAs (146a and 155) in human peri-implant tissue affected by peri-implantitis: a case control study

Identification of common salivary miRNA in oral lichen planus and oral squamous cell carcinoma: systematic review and meta-analysis

Salivary Epigenetic Biomarkers in Head and Neck Squamous Cell Carcinomas

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