The validity, reliability, and utility of the iButton® for measurement of body temperature circadian rhythms in sleep/wake research

Hasselberg, Michael J.; McMahon, James M.; Parker, Kathy P.

doi:10.1016/j.sleep.2010.12.011

Cited by 98 publications

(69 citation statements)

References 38 publications

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“…The Thermochron iButton is such a miniaturized integrated circuit for autonomous temperature logging with on-board memory and battery. It is widely used in various scientific and industrial applications, ranging from body temperature measurements of animals [21,22], to geological applications in volcano monitoring [23] and quality control in industrial shipping and warehousing [24]. …”

Section: Discussionmentioning

confidence: 99%

Improved measurement of the rotor temperature in analytical ultracentrifugation

Zhao

Balbo

Metger

et al. 2014

Analytical Biochemistry

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Sedimentation velocity is a classical method for measuring the hydrodynamic, translational friction coefficient of biological macromolecules. In a recent study, comparing various analytical ultracentrifuges, we have shown that external calibration of the scan time, radial magnification, and temperature are critically important for accurate measurements (Anal. Biochem., 2013, doi: 10.1016/j.ab.2013.05.011). To achieve accurate temperature calibration, we have introduced the use of an autonomous miniature temperature logging integrated circuit (Maxim Thermochron iButton ™) that can be inserted in an ultracentrifugation cell assembly and spun at low rotor speeds. In the present work, we developed an improved holder for the temperature sensor located in the rotor handle. This has the advantage of not reducing the rotor capacity and allows for a direct temperature measurement of the spinning rotor during high-speed sedimentation velocity experiments up to 60,000 rpm. We demonstrate the sensitivity of this approach by monitoring the adiabatic cooling due to rotor stretching during rotor acceleration, and the reverse process upon rotor deceleration. Based on this, we developed a procedure to approximate isothermal rotor acceleration for better temperature control.

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Section: Discussionmentioning

confidence: 99%

Improved measurement of the rotor temperature in analytical ultracentrifugation

Zhao

Balbo

Metger

et al. 2014

Analytical Biochemistry

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“…This gradient has been shown to parallel changes in core body temperature and thus serves as a proxy for it. 27,28 First, values from proximal and distal sensors were pooled. Subsequently, distal values were subtracted from the proximal ones (see figure 1A for a DPG example).…”

Section: Methodsmentioning

confidence: 99%

Significance of circadian rhythms in severely brain-injured patients

et al. 2017

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Objective:To investigate the relationship between the presence of a circadian body temperature rhythm and behaviorally assessed consciousness levels in patients with disorders of consciousness (DOC; i.e., vegetative state/unresponsive wakefulness syndrome or minimally conscious state).Methods:In a cross-sectional study, we investigated the presence of circadian temperature rhythms across 6 to 7 days using external skin temperature sensors in 18 patients with DOC. Beyond this, we examined the relationship between behaviorally assessed consciousness levels and circadian rhythmicity.Results:Analyses with Lomb-Scargle periodograms revealed significant circadian rhythmicity in all patients (range 23.5–26.3 hours). We found that especially scores on the arousal subscale of the Coma Recovery Scale–Revised were closely linked to the integrity of circadian variations in body temperature. Finally, we piloted whether bright light stimulation could boost circadian rhythmicity and found positive evidence in 2 out of 8 patients.Conclusion:The study provides evidence for an association between circadian body temperature rhythms and arousal as a necessary precondition for consciousness. Our findings also make a case for circadian rhythms as a target for treatment as well as the application of diagnostic and therapeutic means at times when cognitive performance is expected to peak.

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“…Miniature temperature data loggers have been used recently in telemetry-based systems to record body temperatures in humans (Van Marken Lichtenbelt et al 2006;Sarabia et al 2008;Hasselberg et al 2013) and of different animal species of all sizes (Kinahan et al 2007;Beatty et al 2008a;Downs et al 2008;Borderas et al 2009;Schrader et al 2009;Hilmer et al 2010;Lohse et al 2010;Cambras et al 2011;Loehr 2012;McMaster & Downs 2013), through surgical implantations, insertions into the gastrointestinal tract, or attachment to the animal's outer surface.…”

Section: Introductionmentioning

confidence: 99%

Application of the iButton® for measurement of the rumen temperature circadian rhythms in lambs

Piccione

Rizzo

Casella

et al. 2013

Biological Rhythm Research

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Fazio (2014) Application of the iButton® for measurement of the rumen temperature circadian rhythms in lambs, Biological Rhythm Research, 45:3, 375-381,The aim of this study was to investigate the daily rhythm of rumen temperature (T rumen ) in lambs by means of the iButton®. Temperature data loggers were orally implanted in five, clinically healthy, male Comisana lambs (150 ± 5 days old; 31.5 ± 1 kg) under natural environmental conditions in order to record the daily course of T rumen . After six days of implantation, animals were slaughtered and iButtons® were recovered from the rumen. One-way repeated-measures analysis of variance (ANOVA), applied to evaluate the effect of time of day on T rumen , showed significant differences (p < 0.0001) in all days of monitoring. The application of the statistical analysis of cosinor indicated the existence of a significant daily rhythm (p < 0.001), with nocturnal acrophase (from 17.21 to 20.59 h). These findings provide new information on the relationship between circadian rhythms of rectal and rumen temperature, improving knowledge about their temporal organization in ovine species.

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The validity, reliability, and utility of the iButton® for measurement of body temperature circadian rhythms in sleep/wake research

Cited by 98 publications

References 38 publications

Improved measurement of the rotor temperature in analytical ultracentrifugation

Improved measurement of the rotor temperature in analytical ultracentrifugation

Significance of circadian rhythms in severely brain-injured patients

Application of the iButton® for measurement of the rumen temperature circadian rhythms in lambs

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