The value of 18F-FDG PET/CT for the detection of distant metastases in high-risk patients with head and neck squamous cell carcinoma

Haerle, Stephan K.; Schmid, Daniel T.; Ahmad, Nader; Hany, Thomas F.; Stoeckli, Sandro J.

doi:10.1016/j.oraloncology.2011.05.011

Cited by 82 publications

(80 citation statements)

References 25 publications

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“…The role of PETCT scan in the initial evaluation of locoregionally advanced head and neck cancers is well established [9]. The purpose of PETCT is this scenario is to identify occult synchronous distant metastases.…”

Section: Discussionmentioning

confidence: 99%

PET Scan in Head and Neck Tumours in a Developing Country Like India: Is It a Must?

Kapre

Dabholkar²

2013

Indian J Otolaryngol Head Neck Surg

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To study the impact of Positron emission tomography (PET) and its incremental value in diagnosing an unknown primary tumour with secondaries in the head and neck; recurrent head and neck cancers (confirmation of suspected recurrences and re-staging); and staging of head and neck tumours. This was a prospective observational study where 60 patients of head and neck tumours under the clinical settings as described above were evaluated. Thorough clinical examination and necessary radiological and histopathological investigations were done. All patients underwent a PET scan, the results of which were correlated with histopathological examination. Sensitivities, specificities, positive and negative predictive values, false positives and false negatives of PET scan in the different indications were calculated. The study included 11 patients of unknown primary, 28 patients with suspected recurrent tumours and 21 patients where PET scan was done for initial staging. PETCT scan was able to detect the primary in 3 out of 11 patients (27.27 %) who presented with cervical metastases with an unknown primary. In 2 of the 8 patients where a primary tumour was not found, PETCT detected distant metastases. For recurrent tumours, PETCT scan showed sensitivity, specificity, positive predictive value and negative predictive value as 100, 72.72, 85 and 100 % respectively. In restaging of recurrent disease, 4 out of 28 patients were detected to have distant metastases. In 7 cases of locoregionally advanced tumors, where PETCT scan was used for pre-treatment staging, it detected distant metastases in 4 of 7 patients. In the patients with N0 neck status PETCT scan showed a sensitivity, specificity, positive predictive value and negative predictive value of 100, 66.67, 50 and 100 % respectively. PETCT scan was able to alter the plan of management in 15 out of 60 patients. Thus, in carefully selected patients PETCT scan can provide incremental information that proves invaluable in these circumstances even in a developing country like India. In all the settings, PETCT scan demonstrated a very high negative predictive value. Hence, negative PETCT scan could be interpreted as absence of disease with reasonable assurance.

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Section: Discussionmentioning

confidence: 99%

PET Scan in Head and Neck Tumours in a Developing Country Like India: Is It a Must?

Kapre

Dabholkar²

2013

Indian J Otolaryngol Head Neck Surg

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“…59 Table 3 summarizes available studies comparing the performances of different imaging approaches to detect distant metastasis of HNSCC. 52,53,[58][59][60][61][62][63] Globally, all these studies indicate that PET 6 CT is superior to conventional imaging. 18 F-FDG-PET shows higher accuracy (90-95%) than CT for the detection of distant metastasis.…”

Section: Lymph Node Involvement (Nodal Staging)mentioning

confidence: 93%

“…18 F-FDG-PET shows higher accuracy (90-95%) than CT for the detection of distant metastasis. 60,61,63 Given the very high negative-predictive value (NPV), it suggests that in case of negative PET scan, other imaging techniques are not necessary. Nevertheless, the PPV for detecting SPT or distant metastasis is around 60%, suggesting that additional diagnostic methods are still necessary to exclude false-positive results.…”

Section: Lymph Node Involvement (Nodal Staging)mentioning

confidence: 99%

Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist

Cacicedo¹,

Navarro²,

Hoyo³

et al. 2016

BJR

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Squamous cell carcinoma is the most common malignant tumour of the head and neck. The initial TNM staging, the evaluation of the tumour response during treatment, and the long-term surveillance are crucial moments in the approach to head and neck squamous cell carcinoma (HNSCC). Thus, at each of these moments, the choice of the best diagnostic tool providing the more precise and larger information is crucial. Positron emission tomography with fluorine-18 fludeoxyglucose integrated with CT ( 18

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“…In head-and-neck cancer patients, liver metastases can occur despite being relatively rare. The lack of portal-venous contrast-enhanced MRI information about the liver may be compensated for by the available 18 F-FDG PET data, which have been demonstrated to be highly sensitive for assessment of metastatic disease, including liver lesions in patients with head-andneck cancer (24). For patients with the focus on potential liver metastases, such as from breast cancer, colorectal cancer, or neuroendocrine tumors, we perform dedicated MRI of the liver, including dynamic contrast-enhanced sequences and diffusionweighted imaging (Figs.…”

Section: Potential Pet/mri Protocols For Whole-body Oncologic Stagingmentioning

confidence: 99%

Workflow and Scan Protocol Considerations for Integrated Whole-Body PET/MRI in Oncology

et al. 2012

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Learning Objectives: On successful completion of this activity, participants should be able to describe (1) special requirements for planning whole-body PET/MRI examinations; (2) general aspects of whole-body PET/MRI protocols in oncology; and (3) possible artifacts in PET/MRI.Financial Disclosure: An author of this article is a meeting participant or lecturer for Siemens AG. No other relevant relationships that could be perceived as a real or apparent conflict of interest were reported. CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credit. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, participants can access this activity through the SNMMI Web site (http:// www.snmmi.org/ce_online) through September 2013.Integrated PET/MRI systems open exciting possibilities for clinical and research applications. However, compared with PET/CT, PET/MRI is a complex technique resulting in new problems and challenges, especially regarding workflow, scan protocols, and data analysis. This complexity applies in particular to examinations in oncology with partial-or whole-body coverage extending over several bed positions. Unlike diagnostic PET/CT, for which the clinical CT protocols can largely be copied from stand-alone CT, the design of a diagnostic MRI protocol for partial-or whole-body coverage is more complex and has to be adapted to the special requirements of PET/MRI to be both time-efficient and comprehensive. Here, we describe basic considerations concerning workflow, imaging protocols, and image analysis for whole-body PET/MRI in oncology, based on our experience with the first integrated PET/MRI scanner. The aim is to fully and optimally make use of the combined PET/MRI measurements in oncology, including identifying and reducing image artifacts as well as optimizing workflow beyond the mere fusion of 2 image datasets. Thesuccessofcombi ned PET and CT has demonstrated the clinical value of multimodality imaging technology, providing both anatomic and molecular information within a single imaging session. However, whereas CT and especially modern multislice CT are a powerful imaging tool, they still have shortcomings, such as low soft-tissue contrast when compared with MRI. Thus, the combination of PET and MRI might be clinically advantageous over PET/ CT for some indications. Moreover, because MRI has more potential for functional and molecular imaging than does CT, the combination of PET with MRI offers completely new opportunities for research applications and for molecular imaging in general.As a consequence, a lot of effort has been put into the development of combined PET and MRI. The first preclinical combined PET/MRI systems were introduced in the 1990s (1-3). Clinically, a PET insert for a standard 3.0-T MRI scanner for simultaneous PET/MRI of t...

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The value of 18F-FDG PET/CT for the detection of distant metastases in high-risk patients with head and neck squamous cell carcinoma

Cited by 82 publications

References 25 publications

PET Scan in Head and Neck Tumours in a Developing Country Like India: Is It a Must?

PET Scan in Head and Neck Tumours in a Developing Country Like India: Is It a Must?

Role of fluorine-18 fluorodeoxyglucose PET/CT in head and neck oncology: the point of view of the radiation oncologist

Workflow and Scan Protocol Considerations for Integrated Whole-Body PET/MRI in Oncology

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