The Value of 2 Mv. Roentgen-Ray Therapy in Differentiated Thyroid Carcinoma

Smedal, Magnus I.; Salzman, Ferdinand A.; Meissner, William A.

doi:10.2214/ajr.99.2.352

Cited by 36 publications

(8 citation statements)

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“…Jacobson (1 954) found that papillary tumours were relatively sensitive to a dosage of 10000 rad, but that the giant-celled anaplastic tumours were radio-resistant. Using a 2-MeV source, Smedal et al (1967) confirmed the relative sensitivity of papillary tumours in contrast to the resistance of follicular carcinomas. Greene (1969), from a unique personal experience, concluded that radiotherapy had little effect on long term survival.…”

Section: Discussionmentioning

confidence: 79%

Treatment of thyroid cancer in 293 patients

Staunton

Greening

1976

Journal of British Surgery

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Two hundred and ninety-three patients with thyroid cancer were treated at The Royal Marsden Hospital, London, between 1931 and 1963. Thirty-six per cent of the tumours were papillary, 21 per cent follicular, 1 per cent medullary and 42 per cent anaplastic. Surgery combined with radiotherapy formed the commonest treatment regime. Thirty-six per cent of the patients with papillary carcinoma survived for 20 years, 20 per cent with follicular tumour and 4 per cent with anaplastic carcinoma. The present series indicates that treatment influences the survival time, confirms the prognostic value of histology and age and shows that papillary node metastases do not prejudice survival.

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Section: Discussionmentioning

confidence: 79%

Treatment of thyroid cancer in 293 patients

Staunton

Greening

1976

Journal of British Surgery

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“…Some authors advocate this type of treatment for its advantageous impact on the outcome of the dis- ease, but without a systematic investigation of the surviv al results [1][2][3][4][5][6][7][8]. Others have reported a decrease in local/ regional relapses following external irradiation [9][10][11][12], Not all authors accept that there is a favourable effect of external irradiation in diminishing local/regional re lapse and mortality [13,14].…”

Section: Introductionmentioning

confidence: 99%

Prophylactic External Irradiation in Differentiated Thyroid Cancer: A Retrospective Study over a 30-Year Observation Period

Ésik

Németh²,

Eller³

1994

Oncology

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Following surgery which left no macroscopic residue, 114 patients with differentiated thyroid cancer (58 papillary, 56 follicular) were subgrouped on the basis of the dose of externally applied prophylactic postoperative radiation: group 1 received an adequate dose of radiation (≥4,500 cGy of telecobalt, ≥4,000 R of orthovoltage therapy), while group 2 received an inadequate dose of radiation (this group included non-irradiated patients). Local/regional-relapse-free survival (LRRFS), distant-metastatic-relapse-free survival (DMRFS) and total-cause-specific survival (TCSS) were calculated by means of life-table analysis for each histologic type. TCSS and LRRFS were significantly (p < 0.001) better for group 1 in papillary cancer. No difference was found in DMRFS. LRRFS was significantly (p < 0.001) better for group 1 in follicular cancer. No differences were found in TCSS and DMRFS. We conclude that (1) prophylactic postoperative external irradiation is an effective method for survival prolongation in papillary cancer, reducing local/regional recurrences, and (2) external irradiation should be considered in the postoperative management of follicular cancer, to diminish local/regional relapse.

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“…The importance of local control has been emphasized by Smedal [30] and "in some patients, prolonged survival is possible" [4]. Every effort should be made toward achieving local control since, in Frazell's experience, the majority of those patients with recurrent poorly differentiated tumors died within a year [7], and this may have been due to difficult surgical removal 1191.…”

Section: Commentsmentioning

confidence: 99%

Postoperative external irradiation in thyroid carcinoma: A clinical experience of 20 treated patients and literature radiotherapy review

Ampil

1985

Journal of Surgical Oncology

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A retrospective review is presented of 20 evaluable patients who underwent surgical resection or biopsy for limited stage thyroid carcinoma at two institutions between 1963 and 1983. The majority had external radiotherapy to the whole neck and upper mediastinum and the total dose given varied from 3,800 to 6,000 rads. For group I (microscopic residual disease), 81.8% (9/11 patients) local control was observed during a follow-up period of 2-75 months with adjuvant postoperative irradiation compared to surgery alone, 14.2% (1/7 patients) local control; 75% (9/12 patients) are alive and well. In group II (gross residual disease), local control was 25% (2/8 patients) and the survival was 14 and 60 months, respectively, with external radiotherapy. The beneficial external irradiation effects in terms of local control and survival even in some patients with gross unresectable disease are reiterated from this small series. A literature review summary of external radiotherapy results is also presented.

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The Value of 2 Mv. Roentgen-Ray Therapy in Differentiated Thyroid Carcinoma

Cited by 36 publications

References 0 publications

Treatment of thyroid cancer in 293 patients

Treatment of thyroid cancer in 293 patients

Prophylactic External Irradiation in Differentiated Thyroid Cancer: A Retrospective Study over a 30-Year Observation Period

Postoperative external irradiation in thyroid carcinoma: A clinical experience of 20 treated patients and literature radiotherapy review

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