The value of acoustic radiation force impulse imaging in preoperative prediction for efficacy of high-Intensity focused ultrasound uterine fibroids ablation

Zhang, Dan-ling; Liu, Xinxiu; Tang, Jianguo; Wu, Songsong; Lin, Ning; Ding, Gui-Sheng; Pan, Xiaoli; Chen, Sheng

doi:10.1080/02656736.2020.1758803

Cited by 9 publications

(6 citation statements)

References 25 publications

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“…The reasons for these variabilities are still unclear. It has been found [10] that the preoperative shear wave velocity (SWV) value of uterine fibroids is negatively correlated with the ablation rate. Uterine fibroids with higher SWV values are more difficult to ablate than those with lower SWV values.…”

Section: Discussionmentioning

confidence: 99%

“…Acoustic Radiation Force Pulse Imaging Technology (ARFI) is a new elastography-based technology that integrates virtual touch tissue quantification (VTQ) with virtual touch tissue imaging (VTI), and has been found to effectively identify the properties of tissues by detecting the elastic stiffness of tissues [7][8][9]. Previous studies [10] have confirmed that the ARFI technique is a practical and feasible noninvasive ultrasound technique for the preoperative prediction of the efficacy of HIFU uterine fibroid ablation. Studies have shown that with the same single point of sound power, uterine fibroids with different Shear Wave Velocity (SWV) show differences in the efficacy of HIFU ablation.…”

Section: Introductionmentioning

confidence: 99%

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Differences in the therapeutic effects of high-intensity focused ultrasound (HIFU) ablation on uterine fibroids with different shear wave velocity (SWV): a study of histopathological characteristics

Zhang

Chen

et al. 2020

International Journal of Hyperthermia

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Objective: To explore correlations between the therapeutic effect of high intensity focused ultrasound (HIFU) and histopathological characteristics of uterine fibroids with different Shear Wave Velocity (SWV) values. Methods: A retrospective study was conducted on 36 women (43 fibroids) who had undergone high intensity focused ultrasound (HIFU) uterine fibroids ablation between January 2019 and January 2020. Preoperative fibroids tissue sections were obtained for histopathological examination. The pathological sections were stained with Masson-trichrome, and were observed and imaged under a Low-power microscope (4 Â 10), while the smooth muscle cell (SMC) and collagen fiber content were semi-quantitatively measured. Preoperative fibroid SWV was measured using the Virtual Touch tissue quantification (VTQ) technique. Within one month after HIFU ablation, all patients had undergone a pelvic cavity MRI examination, which measured the size, volume, and non-perfused volume (NPV) of the fibroids. The formula: the ablation rate ¼ NPV/target fibroid volume Â 100% was used to calculate the ablation rate of the uterine fibroids. Correlation analysis of SWV values, HIFU ablation rate, along with the smooth muscle cell (SMC) and collagen fiber content, were conducted using the Spearman's correlation test. Results: The collagen fiber and SMC content of the preoperative fibroids were 32.09 ± 15.90%/view and 37.61 ± 15.32%/view, respectively. Preoperative fibroid SWV value was 3.56 ± 0.71 m/s. Preoperative fibroid SWV was negatively correlated with SMC content (r ¼ À0.445, p ¼ 0.003), but positively correlated with collagen fiber content (r ¼ 0.454, p ¼ 0.002). The ablation rate was negatively correlated with collagen fiber content (r ¼ À0.377, p ¼ 0.013), but positively correlated with SMC content (r ¼ 0.402, p ¼ 0.007). Conclusion: Differences in histopathological characteristics may be important factors that induce differences in the therapeutic effects of HIFU ablation on uterine fibroids with different SWV values.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Differences in the therapeutic effects of high-intensity focused ultrasound (HIFU) ablation on uterine fibroids with different shear wave velocity (SWV): a study of histopathological characteristics

Zhang

Chen

et al. 2020

International Journal of Hyperthermia

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“…The changes in tissue stiffness can be estimated with ultrasound using acoustic radiation force impulse (ARFI) imaging or shear wave elastography (SWE). US-ARFI imaging has predictive value preablation in uterine fibroids [ 77 ]. Ultrasound SWE can provide real-time quantitative estimates of tissue stiffness [ 78 ].…”

Section: Ultrasoundmentioning

confidence: 99%

A Review of Imaging Methods to Assess Ultrasound-Mediated Ablation

et al. 2022

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Ultrasound ablation techniques are minimally invasive alternatives to surgical resection and have rapidly increased in use. The response of tissue to HIFU ablation differs based on the relative contributions of thermal and mechanical effects, which can be varied to achieve optimal ablation parameters for a given tissue type and location. In tumor ablation, similar to surgical resection, it is desirable to include a safety margin of ablated tissue around the entirety of the tumor. A factor in optimizing ablative techniques is minimizing the recurrence rate, which can be due to incomplete ablation of the target tissue. Further, combining focal ablation with immunotherapy is likely to be key for effective treatment of metastatic cancer, and therefore characterizing the impact of ablation on the tumor microenvironment will be important. Thus, visualization and quantification of the extent of ablation is an integral component of ablative procedures. The aim of this review article is to describe the radiological findings after ultrasound ablation across multiple imaging modalities. This review presents readers with a general overview of the current and emerging imaging methods to assess the efficacy of ultrasound ablative treatments.

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“…Some studies have tried using HIFU-based ARFI to monitor conditions of the thermal ablation. 19,20 This is because the ablated tissue has different elastic properties when compared to the unablated. In addition to its potential in the surgery monitoring, it is also possible to use this ARFI technique for predicting location of the HIFU focus since tissue motion within the focal region is larger than the outside.…”

Section: Introductionmentioning

confidence: 99%

Technical note: Evaluation of the acoustic radiation force imaging for predicting HIFU focus with in vitro and ex vivo experiments

et al. 2023

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BackgroundHigh‐intensity focused ultrasound (HIFU) is currently used for the treatment of various diseases, but it still lacks a reliable technique in the preoperative stage to accurately place its “energy blade” onto diseased targets. Acoustic radiation force imaging (ARFI) was recently introduced to tackle this issue, but its applicability and limitations were not clear.PurposeThe aim of this study was to evaluate the performance of ARFI method in prediction of HIFU focal location at the preoperative stage.MethodsA point spread function (PSF) localization method, which was borrowed from the ultrasound super resolution field, was used to validate the core autocorrelation‐based motion estimation algorithm in the ARFI procedure. Accuracy of the ARFI method for estimating the HIFU focus were tested with in vitro and ex vivo experiments with a clinically equivalent HIFU system. Comparisons were made between the estimated focal locations and those of the damaged area after the testing objects were cut open.ResultsResults showed that the PSF localization was able to serve as a validating method for motion detection only when the tissue displacement was large. With the ARFI method, location of the HIFU focus could be accurately predicted by a 2D motion map preoperatively, and the axial spatial errors were less than 0.5 mm. However, the derived 2D motion maps can only be valuable when the acoustic stimulation in ARFI were strong enough, which was probably due to the fact that the HIFU focal locations were at large depths and the ultrasound imaging signal had low signal to noise ratio.ConclusionThe ARFI method was indeed an accurate technique for preoperatively predicting HIFU focus in vitro and ex vivo. If clinical applications were to be considered, particularly in deep tissues, efforts might need to be made to improve ability of the ultrasound motion estimation technique.

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The value of acoustic radiation force impulse imaging in preoperative prediction for efficacy of high-Intensity focused ultrasound uterine fibroids ablation

Cited by 9 publications

References 25 publications

Differences in the therapeutic effects of high-intensity focused ultrasound (HIFU) ablation on uterine fibroids with different shear wave velocity (SWV): a study of histopathological characteristics

Differences in the therapeutic effects of high-intensity focused ultrasound (HIFU) ablation on uterine fibroids with different shear wave velocity (SWV): a study of histopathological characteristics

A Review of Imaging Methods to Assess Ultrasound-Mediated Ablation

Technical note: Evaluation of the acoustic radiation force imaging for predicting HIFU focus with in vitro and ex vivo experiments

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