The value of an immune response to Mycobacterium tuberculosis in patients with chronic posterior uveitides revisited: utility of the new IGRAs

Clinical characteristic and therapy results of presumed ocular tuberculosis and their relation to HIV status

“…[15][16][17][18][19] The presentation of granulomatous inflammation in HIV/AIDS patients in study are in accordance to several other studies which were mainly choroidal granulomas and tubercles. [20][21][22][23][24][25][26][27] Our findings that ocular TB in HIV/ AIDS patients all have systemic manifestation are in accordance to Babu et al study that found in HIV/ AIDS patients, all ocular TB patients have pulmonary TB, and among them two cases have coexistent central nervous system TB and one case had abdominal TB.…”

Intraocular Tuberculosis

“…Studies of IGRAs in patients with uveitis from multiple centers have suggested comparable sensitivity, but improved specificity, relative to TST. 41,42 Although the IGRA cannot replace conventional methods to diagnose active TB, they may play a role in certain patient population, including immunocompromised patients, young children who cannot produce a sputum sample, patients with smear-negative pulmonary TB, and those with extrapulmonary disease, especially in highly endemic areas. 43 PCR is a sensitive and highly specific technique that can amplify mycobacteial DNA several-fold for easy detection.…”

“…QuantiFERON-TB Gold identifies latent TB infection better than the tuberculin skin test in a population vaccinated by BCG. [40][41][42] It could thus be a useful tool for identifying more accurately those patients who may benefit from full anti-TB treatment in the management of presumed TB-related uveitis. Studies of IGRAs in patients with uveitis from multiple centers have suggested comparable sensitivity, but improved specificity, relative to TST.…”

Estudio clínico e inmunológico de la acción de adalimumab en el tratamiento de las uveítis inmunomediadas refractarias

“…Nuestro grupo aplicó este cribaje a pacientes con uveítis que afectaban al segmento posterior, ya fuesen de nueva aparición o antiguas con mala respuesta al tratamiento, incorporando las nuevas técnicas de detección de producción de interferón-gamma linfocitario (las IGRAS ya varias veces mencionadas en este capítulo). 220 En este estudio reflejamos cómo la uveítis tuberculosa es una entidad vigente y que conviene sospechar especialmente en pacientes que cumplan cualquiera de estos dos criterios:…”

“…En estos casos, nuestro estudio demuestra cómo la aplicación de un cribaje sistemático incorporando las nuevas herramientas diagnósticas de tuberculosis, permite detectar casos con uveítis tuberculosas erróneamente diagnosticadas como inmuno-mediadas que se pueden beneficiar enormemente de un tratamiento correcto. 220 La aplicación de este cribaje sistemático es pues decisivo antes de iniciar tratamiento con fármacos anti-TNF en pacientes de estas características (que en realidad constituyen un porcentaje alto del total de los que reciben este tipo de tratamientos).…”