The Value of Cervical Colposcopic Assessment in the Management of Genital Hormone Deficiency

Roberts, A. D. G.; Cordiner, J. W.; Hart, D. M.

doi:10.1089/gyn.1986.2.141

Cited by 2 publications

References 8 publications

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The variation in cervical hydroxyproline and cervical water with age

Roberts

Cordiner

Hart

et al. 1988

BJOG

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Summary. The squamocolumnar junction is frequently not visible in the postmenopausal patient. This study attempts to identify some of the changes in the cervix that may account for this observation. Twentyfour cervical biopsy samples taken at the squamocolumnar junction were analysed for hydroxyproline (collagen) and water content. There was significantly more hydroxyproline (collagen) in the premenopausal woman than the postmenopausal woman. Similarly, there was higher percentage of water in the biopsies in the premenopausal woman than the postmenopausal woman. Further samples obtained deeper in the cervical stroma did not confirm these differences. It appears likely that differences in cervical water and cervical collagen near the surface of the cervix account, at least in part, for the lack of visibility of the squamocolumnar junction in the older woman.

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The variation in cervical hydroxyproline and cervical water with age

Roberts

Cordiner

Hart

et al. 1988

BJOG

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Unsatisfactory Colposcopy in Late Postmenopausal Women: The Effectiveness of Conjugated Topic Estrogen

Schwingel,

Reis,

de Mello

et al. 2024

Preprint

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Background Menopause’s hypoestrogenic state which is characterized by atrophy can lead to incorrect interpretation of the cytological smears, as well as it can turn colposcopy challenging because of non-visualization of squamocolumnar junction. This study aims to determine the effect of estrogen therapy on the topography of the colposcopic transformation zone in hypoestrogenic patients and its effect on the differentiation of abnormal Papanicolaou smears secondary to atrophy and true intraepithelial lesions to improve the management of cervical disease after menopause. Methods This was a retrospective evaluation of postmenopausal women aged 50 years or older who were treated between January 2010 and February 2019 at a public hospital in southern Brazil and who had abnormal cervical cytologies and negative initial colposcopies and who were subjected to topical conjugated estrogen therapy and follow-up evaluations. Results Ninety-eight patients aged 57 years and 9.5 years after menopause were included. After 3 months of conjugated-topic estrogen therapy, the rate of satisfactory colposcopy ranged from 20.4–32.7%. Of the 78 (79.6%) subjects with a type 3 transformation zone in the entry colposcopy, 66 (67.3%) remained in the same topography. Additionally, of the 98 patients, 67 (68%) had negative cervical cytology results after treatment. Persistence of high-grade intraepithelial lesions was observed in 33.3% of the patients, 16.7% of whom were diagnosed with microcarcinoma. Conclusion The use of conjugated topical estrogen improved the accuracy of cytology smears in late postmenopausal women. However, it did not show a good response in the topography of the transformation zone and, consequently, a satisfactory colposcopy rate.

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The Value of Cervical Colposcopic Assessment in the Management of Genital Hormone Deficiency

Cited by 2 publications

References 8 publications

The variation in cervical hydroxyproline and cervical water with age

The variation in cervical hydroxyproline and cervical water with age

Unsatisfactory Colposcopy in Late Postmenopausal Women: The Effectiveness of Conjugated Topic Estrogen

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