The Value of Circulating Circular RNA in Cancer Diagnosis, Monitoring, Prognosis, and Guiding Treatment

Zhang, Yunjing; Wang, Ying; Su, Xinwan; Wang, Ping; Lin, Weiqiang

doi:10.3389/fonc.2021.736546

Cited by 14 publications

(15 citation statements)

References 129 publications

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“…In particular, in the current era of the precision medicine, the need to use the so-called “liquid biopsy” like easily accessible body fluids provides great advantages since the collection process is less invasive than tissue collection, and can be reiterated over the time in the processes of follow-up and real-time monitoring of the patients. In addition, the metabolites contained in the liquid biopsies have the power of mirroring multiple biochemical processes and pathways happening in tissues [ 26 – 28 ].…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the human metabolome

et al. 2022

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Background The sexual dimorphism represents one of the triggers of the metabolic disparities between the organisms, advising about wild implications in research or diagnostics contexts. Despite the mounting recognition of the importance of sex consideration in the biomedical fields, the identification of male- and female-specific metabolic signatures has not been achieved. Main body This review pointed the focus on the metabolic differences related to the sex, evidenced by metabolomics studies performed on healthy populations, with the leading aim of understanding how the sex influences the baseline metabolome. The main shared signatures and the apparent dissimilarities between males and females were extracted and highlighted from the metabolome of the most commonly analyzed biological fluids, such as serum, plasma, and urine. Furthermore, the influence of age and the significant interactions between sex and age have been taken into account. Conclusions The recognition of sex patterns in human metabolomics has been defined in diverse biofluids. The detection of sex- and age-related differences in the metabolome of healthy individuals are helpful for translational applications from the bench to the bedside to set targeted diagnostic and prevention approaches in the context of personalized medicine. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Sex differences in the human metabolome

et al. 2022

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“…Circular RNAs can also be detected in various body fluids such as cerebrospinal fluid (CSF), blood, urine, and saliva ( Lai et al, 2022 ; Zhang et al, 2021b ). Abundant levels of circular RNAs are expressed in the CSF, although these are less diverse than those in the blood ( Wang et al, 2022 ); by contrast, much more diverse and higher levels of circular RNAs are expressed in the blood than in urine or saliva ( Bahn et al, 2015 ; Hutchins et al, 2021 ; Koh et al, 2014 ).…”

Section: Intracellular Circular Rnas As Biomarkers and Therapeutic Ta...mentioning

confidence: 99%

Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAs

Son

Han

2023

Molecules and Cells

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RNAs are versatile molecules that are primarily involved in gene regulation and can thus be widely used to advance the fields of therapeutics and diagnostics. In particular, circular RNAs which are highly stable, have emerged as strong candidates for use on next-generation therapeutic platforms. Endogenous circular RNAs control gene regulatory networks by interacting with other biomolecules or through translation into polypeptides. Circular RNAs exhibit cell-type specific expression patterns, which can be altered in tissues and body fluids depending on pathophysiological conditions. Circular RNAs that are aberrantly expressed in diseases can function as biomarkers or therapeutic targets. Moreover, exogenous circular RNAs synthesized in vitro can be introduced into cells as therapeutic molecules to modulate gene expression networks in vivo. Depending on the purpose, synthetic circular RNA sequences can either be identical to endogenous circular RNA sequences or artificially designed. In this review, we introduce the life cycle and known functions of intracellular circular RNAs. The current stage of endogenous circular RNAs as biomarkers and therapeutic targets is also described. Finally, approaches and considerations that are important for applying the available knowledge on endogenous circular RNAs to design exogenous circular RNAs for therapeutic purposes are presented.

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“…CircRNAs have attracted a great deal of attention as cancer biomarkers in recent years. The high stability of circRNAs, especially in body fluids such as plasma, and their potential ability to affect cancer-related pathways have made them suitable biomarkers for managing cancer in various ways, including diagnosis, prognosis, or response to treatment [9] . Recent research showed that up-regulation of hsa_circ_0005092 and hsa_circ_0002647 positively correlated with recurrence-free survival and overall survival in GAC patients [10] .…”

Section: Introductionmentioning

confidence: 99%