During their various studies of the clinical use of massive doses of vitamin D, Reed and associates 1 noted that many patients receiving large doses of vitamin A and vitamin D claimed that both the incidence and the severity of their colds were appreciably reduced. No accurate statistics were kept, but it appeared to them that only those subjects receiving both vitamins were thus benefited.This observation was not surprising since many investigators have noted great reduction in the incidence of colds and respiratory infections through the use of fairly liberal quantities of cod liver oil. Holmes and his colleagues,2 for example, reviewed the subject and showed a reduction of about two thirds in the average "lost time" of industrial workers due to colds and respiratory diseases when cod liver oil was furnished. In general Holmes felt that the reduction in colds was due to the vitamin A content of the cod liver oil, although no proof of this could be offered. The doses used by Reed and associates, however, were many times larger than those used by previous workers, and the subjects could not be said to be deficient in vitamins A or D. Whatever effects appeared, therefore, were almost certainly due to some cause other than correction of vitamin deficiency.In view of these facts, it was of interest to study the effects of vitamins A and D in large doses, both singly and combined, on a group of subjects. The purpose of this study was to determine, first, whether any amelioration as regards the incidence and severity of colds was achieved; second, whether one or the other of the vitamins was alone responsible for the effects or whether both were necessary.