The value of colposcopy, high risk HPV-DNA and histopathologic examination in the management of abnormal Pap smear results

Bayramov, Vugar; Şükür, Yavuz Emre; Tezcan, Sevgi

doi:10.5505/tjod.2011.94914

Cited by 1 publication

(3 citation statements)

References 13 publications

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“…This high difference might be a result of regional life-style discrimination. However, the studies using PCR reported higher HPV positive cases among patients with abnormal cytology [13,[15][16][17][18][19][21][22][23][24][25]. We also found HPV in 32.6% of patients with abnormal cytology and our result was in consistent with the previous literature.…”

Section: Discussionsupporting

confidence: 92%

“…Table 4 summarizes the recent studies with available full-text from Turkey investigating the relationship between HPV status and abnormal cytological results. The previous studies from Turkey reported the rate of HPV infection among patients with abnormal cervical cytology between 12% and 80% [13][14][15][16][17][18][19][20][21][22][23][24][25]. This wide range probably originated from the detection method used.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier studies generally reported results by hybrid capture (HC) II system. Two studies from Ankara using HC II reported that the rate of HPV positivity among patients with abnormal cytology were 12% and 19% [14,22]. However, one study from Izmir, western coast of Turkey, reported HPV in 47% of patients with abnormal cytology by using HC II system [20].…”

Section: Discussionmentioning

confidence: 99%

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Relationship between Human Papillomavirus Status and Cervical Cytological Abnormalities in a Low Risk Turkish Population

Uyar¹

2017

OGIJ

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Objectives: To investigate the relationship between human papillomavirus (HPV) genotypes and abnormal cytology results in a local Turkish hospital and to review the recent Turkish literature. Methods: In this cross-sectional study, pap smear and of 7985 patients between October 2012 and September 2014 were reviewed. Patients with abnormal cytology were included in the study. The relationship between HPV status and cervical cytology results were investigated. Results: One hundred and twelve patients (1.4%) had abnormal cervical cytology results. Ninety five patients with abnormal cytological results were finally analyzed. Thirty one (32.6%) patients were positive for HPV. The mean ages of HPV (+) and HPV (-) patients were comparable (42.5±10.1 years vs. 44.6±10.7 years, respectively; P=.382). Two patients had multiple HPV infections. The most common HPV types were HPV 16 (38.2%), HPV 6 (23.5%), HPV 18 (14.7%) and HPV 33 (9.1%). The ratio of diagnostic upgrade after histopathologic examination was significantly higher in HPV (+) ASC-US patients than HPV (-) ASC-US patients (50% vs. 5.8%, respectively; P=.002). The ratio of diagnostic upgrade after histopathologic examination was significantly higher in HPV (+) LSIL patients than HPV (-) LSIL patients (45.5% vs. 0%, respectively; P=.030). Conclusion: While developing national and regional screening and vaccination strategies for cervical cancer it's important to define HPV genotype distribution and its relationship with screening results in different local regions of the country.

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