The value of complete blood count for the prognosis analysis of preoperative esophageal squamous cell carcinoma

Lv, Xiang; Han, Songtao; Xu, Bin; Deng, Yuxiao; Feng, Yilong

doi:10.1186/s12885-021-08789-2

Cited by 6 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, according to the results, the cutoff values obtained by the two methods were not exactly the same. Nevertheless, to date, there are no clear cutoff values for determining the prognosis of EC patients [38]. Therefore, in the future, we plan to explore the best cutoff values and the underlying molecular mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Clinical usefulness of the lymphocyte-to-monocyte ratio and aggregate index of systemic inflammation in patients with esophageal cancer: a retrospective cohort study

et al. 2023

View full text Add to dashboard Cite

Background Multiple perioperative inflammatory markers are considered important factors affecting the long-term survival of esophageal cancer (EC) patients. Hematological parameters, whether single or combined, have high predictive value. Aim To investigate the inflammatory status of patients with preoperative EC using blood inflammatory markers, and to establish and validate competing risk nomogram prediction models for overall survival (OS) and progression-free survival (PFS) in EC patients. Methods A total of 508 EC patients who received radical surgery (RS) treatment in The First Affiliated Hospital of Zhengzhou University from August 5, 2013, to May 1, 2019, were enrolled and randomly divided into a training cohort (356 cases) and a validation cohort (152 cases). We performed least absolute shrinkage and selection operator (LASSO)-univariate Cox- multivariate Cox regression analyses to establish nomogram models. The index of concordance (C-index), time-dependent receiver operating characteristic (ROC) curves, time-dependent area under curve (AUC) and calibration curves were used to evaluate the discrimination and calibration of the nomograms, and decision curve analysis (DCA) was used to evaluate the net benefit of the nomograms. The relative integrated discrimination improvement (IDI) and net reclassification improvement (NRI) were calculated to evaluate the improvement in predictive accuracy of our new model compared with the AJCC staging system and another traditional model. Finally, the relationship between systemic inflammatory response markers and prognostic survival was explored according to risk plot, time-dependent AUC, Kaplan–Meier and restricted cubic spline (RCS). Results Based on the multivariate analysis for overall survival (OS) in the training cohort, nomograms with 10 variables, including the aggregate index of systemic inflammation (AISI) and lymphocyte-to-monocyte ratio (LMR), were established. Time-dependent ROC, time-dependent AUC, calibration curves, and DCA showed that the 1-, 3-, and 5 year OS and PFS probabilities predicted by the nomograms were consistent with the actual observations. The C-index, NRI, and IDI of the nomograms showed better performance than the AJCC staging system and another prediction model. Moreover, risk plot, time-dependent AUC, and Kaplan–Meier showed that higher AISI scores and lower LMR were associated with poorer prognosis, and there was a nonlinear relationship between them and survival risk. Conclusion AISI and LMR are easy to obtain, reproducible and minimally invasive prognostic tools that can be used as markers to guide the clinical treatment and prognosis of patients with EC.

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical usefulness of the lymphocyte-to-monocyte ratio and aggregate index of systemic inflammation in patients with esophageal cancer: a retrospective cohort study

et al. 2023

View full text Add to dashboard Cite

show abstract

“…It has been widely studied as a predictor or prognostic factor for advanced cancers, including ESCC, gastric cancer, ovarian cancer, and oral cancer ( 25 – 28 ). With regard to defining the threshold for elevated LMR, previous studies applied critical values from 2.95 to 4 in patients with EC ( 25 , 29 , 30 ). Similarly, we defined the threshold for PLR elevation as 3.26, which is consistent with the threshold of previous studies.…”

Section: Discussionmentioning

confidence: 99%

A Novel Model Combining Tumor Length, Tumor Thickness, TNM_Stage, Nutritional Index, and Inflammatory Index Might Be Superior to the 8th TNM Staging Criteria in Predicting the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy

Chen

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

BackgroundWe aimed to determine whether the tumor length and tumor thickness should be used as prognostic factors for esophageal squamous cell carcinoma (ESCC) patients treated with definitive chemoradiotherapy (dCRT).MethodsA retrospective analysis consists of 902 non-operative ESCC patients received dCRT. The nomogram was used to predict the survival. Besides, Restricted Cubic Splines (RCS) was used to examine the relationship between prognostic factors and survival outcomes. Finally, the prognostic index (PI) scores were constructed according to the tumor length and tumor thickness, and the patients were divided into the low-, medium-, and high-risk groups.ResultsThe median follow-up of overall survival (OS) and progression-free survival (PFS) were 23.0 months and 17.5 months. Multivariate Cox regression analysis showed that tumor length and tumor thickness were independent prognostic factors associated with survival. Our novel nomograms for OS and PFS were superior to the TNM classification (p < 0.001). Besides, RCS analysis demonstrated that the death hazard of tumor length and tumor thickness sharply increased at 7.7 cm and 1.6 cm (p < 0.001). Finally, there were significant differences for ESCC patients with clinical TNM stage group of the OS and PFS in different risk groups. The higher risk group was significantly associated with shorter OS and PFS in ESCC patients (both p < 0.001 for all).ConclusionThe study results suggest that the novel models integrating tumor length and tumor thickness may provide a simple and widely available method for evaluating the prognosis of non-operative ESCC patients. The tumor length and tumor thickness should be considered as prognostic factors for ESCC.

show abstract

“…A recent study also found that high NLR (> 2.20) and PLR (> 110) were associated with larger tumor size, and that NLR was a prognostic factor for resectable ESCC 23 . Another retrospective study of 1587 ESCC patients who underwent esophagectomy found that a high pre-operative NLR (> 3.29) and low LMR (< 2.95) could predict worse survival in patients with ESCC 24 . A recent meta-analysis also confirmed that a high NLR may predict a poor prognosis, including overall survival, cancer-specific survival, and progression-free survival of ESCC patients 36 .…”

Section: Discussionmentioning

confidence: 99%

“…Most previous studies have reported the roles of NLR/LMR/PLR in patients with advanced-stage esophageal squamous cell carcinoma (ESCC) or in those who received chemoradiation therapy 21 – 24 , however studies focusing on superficial esophageal cancer or endoscopic resection are still lacking. Therefore, the aims of this study were to evaluate the associations between NLR, LMR, PLR and SESCC, and identify a non-invasive convenient biomarker for the long-term prognosis of patients with SESCC.…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance of systemic inflammatory response markers in patients with superficial esophageal squamous cell carcinomas

Chen

Lee²,

Tsai³

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Endoscopic resection or esophagectomy has becoming the standard treatment for superficial esophageal squamous cell carcinomas (SESCC), but some patients may develop disease progression or second primary cancers after the therapies. Neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), and platelet to lymphocyte ratio (PLR) reflect the balance between pro-cancer inflammatory and anti-cancer immune responses, however their roles in SESCC are still unknown. We consecutively enrolled patients with newly diagnosed SESCC (clinical stage Tis or T1N0M0) who were treated at our institute. Pre-treatment NLR, LMR and PLR were assessed and then correlated with clinical factors and long-term survival. A total of 156 patients were enrolled (152 males, 4 females; median age: 52.2 years), of whom 104 received endoscopic resection and 52 were treated with esophagectomy or chemoradiation.. During a mean follow-up period of 60.1 months, seventeen patients died of ESCCs, and 45 died of second primary cancers. The 5-year ESCC-specific survival and 5-year overall survival rate were 86% and 57%, respectively. LMR (P < 0.05) and NLR (P < 0.05), but not PLR were significantly correlated with overall survival. Receiver operating characteristic curve analysis showed optimal LMR and NLR cut-off values of 4 and 2.5, respectively, to predict a poor prognosis. Patients with a high NLR or low LMR tended to have longer tumor length, larger circumferential extension, and presence of second primary cancers. Multivariate Cox regression analysis showed that presence of second primary cancers (HR: 5.05, 95%CI: 2.75–9.28), low LMR (HR: 2.56, 95%CI: 1.09–6.03) were independent risk factors for poor survival. A low pre-treatment LMR may be a non-invasive pretreatment predictor of poor prognosis to guide the surveillance program, suggesting that anti-cancer immunity may play a role in the early events of esophageal squamous cancer.

show abstract

The value of complete blood count for the prognosis analysis of preoperative esophageal squamous cell carcinoma

Cited by 6 publications

References 15 publications

Clinical usefulness of the lymphocyte-to-monocyte ratio and aggregate index of systemic inflammation in patients with esophageal cancer: a retrospective cohort study

Clinical usefulness of the lymphocyte-to-monocyte ratio and aggregate index of systemic inflammation in patients with esophageal cancer: a retrospective cohort study

A Novel Model Combining Tumor Length, Tumor Thickness, TNM_Stage, Nutritional Index, and Inflammatory Index Might Be Superior to the 8th TNM Staging Criteria in Predicting the Prognosis of Esophageal Squamous Cell Carcinoma Patients Treated With Definitive Chemoradiotherapy

Prognostic significance of systemic inflammatory response markers in patients with superficial esophageal squamous cell carcinomas

Contact Info

Product

Resources

About