The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes

Taşçı, Yasemin; Dilbaz, Berna; Önal, Binnur; Çalışkan, Eray; Dilbaz, Serdar; Doğancı, Levent; Han, Ünsal

doi:10.1016/j.ejogrb.2005.11.049

Cited by 48 publications

(32 citation statements)

References 16 publications

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“…IL-6 levels in maternal blood was valuable in detecting early fetal infection with a sensitivity, specificity, NPV, PPV of 95.1, 91.8, 92.1 and 86.4%, respectively and was comparable to the results of other investigators (Tasci et al, 2006). Also, the finding of higher IL-6 concentrations in cord sera of babies compared with the corresponding maternal samples argues against the dependency of neonatal serum IL-6 concentrations on maternal IL-6 concentrations.…”

Section: Discussionsupporting

confidence: 84%

Microbiological study of cases of early neonatal sepsis and evaluation of the role of C-reactive protein, interleukin-6 and interleukin-8 as diagnostic biomarkers of such cases

El-Mashad¹,

Amrousy²,

Sanosy³

et al. 2017

Afr. J. Microbiol. Res.

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Neonatal sepsis is responsible for significant morbidity and mortality. Its early diagnosis is very important but very difficult. This study aimed to evaluate the value of C reactive protein (CRP), interleukin 6 (IL-6) and interleukin 8 (IL-8) as early diagnostic biomarkers for early neonatal sepsis (ENOS). Forty neonates with prenatal risk for neonatal sepsis with their mother were taken in this study (group I). Ten healthy neonates and their healthy mothers were taken as the control group (group II) in Tanta University Hospital in the period of March to December, 2016. White blood count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) were evaluated in cord blood of neonates and in mother's sera. Also, cultures were done for neonates to confirm neonatal sepsis. The results of this study showed that the gestational age was shorter in the study group than the control group. Staphylococcus aureus represent 55% of the organisms isolated from cases of early neonatal sepsis. WBC, ESR, CRP, IL-6 and IL-8 were significantly higher in the study group than the control group. In the study group, 50% had positive cultures, while there were only 10% in thr control group with P value of 0.001. The sensitivity, specificity, positive predictive value (PPV) and negative predictive values (NPV) for CRP were 88.6, 84.7, 86.9 and 90.4%, for IL-6, they were 92.4, 97.6, 90.4 and 86.6%, for IL-8, they were 90.8, 88.9, 92.4 and 91.7%, respectively. The best sensitivity and NPV was for IL-6. Cord blood CRP alone has little utility in EONS diagnosis. IL-6 and IL-8 has great superiority than CRP when combined with other hematological markers. IL-6 was better diagnostic biomarker for ENOS than IL-8 and CRP.

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Section: Discussionsupporting

confidence: 84%

Microbiological study of cases of early neonatal sepsis and evaluation of the role of C-reactive protein, interleukin-6 and interleukin-8 as diagnostic biomarkers of such cases

El-Mashad¹,

Amrousy²,

Sanosy³

et al. 2017

Afr. J. Microbiol. Res.

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“…Ascending bacterial infections at the maternal-fetal interface 9,10 as well as inflammatory processes at sites remote from the female genital tract [11][12][13][14] are potential pathoetiologic mechanisms of the condition. Chorioamnionitis is a major cause of maternal, fetal, and neonatal morbidity such as stillbirth, 15 premature rupture of membranes, 16 preterm birth, [17][18][19] bronchopulmonary dysplasia, 20,21 and neonatal intensive care unit admissions. 22 More than half of preterm births are thought to be associated with histological chorioamnionitis.…”

Section: Arch Pediatr Adolesc Med 2010;164(2):187-192mentioning

confidence: 99%

Effect of Chorioamnionitis on Early Childhood Asthma

Getahun¹,

Strickland²,

Zeiger³

et al. 2010

Arch Pediatr Adolesc Med

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“…Epidemiologic data indicate that 30-40% of preterm deliveries are associated with cervicovaginal or intrauterine infection [10] . Some of these signals include the secretion of cytokines such as interleukin (IL)-1 ␤ , tumor necrosis factor (TNF)-␣ , IL-8, and IL-6 [11,12] which induce the synthesis and secretion of uterotonic factors, i.e. prostaglandins E 2 and F 2 ␣ [13] , as well as MMPs such as stromelysin 1 (MMP-3) and 3 (MMP-11), MMP-2, and MMP-9, which interfere with the homeostasis of the extracellular matrix responsible for the mechanical strength of the chorioamnion [14,15] .…”

Section: Introductionmentioning

confidence: 99%

Tocilizumab Inhibits Interleukin-6-Mediated Matrix Metalloproteinase-2 and -9 Secretions from Human Amnion Cells in Preterm Premature Rupture of Membranes

Mano

Shibata²,

Sato

et al. 2009

Gynecol Obstet Invest

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Background/Aims: In the present study, we investigated the participation of inflammatory cytokine-induced mediated matrix metalloproteinase (MMP) expressions and inhibition of interleukin (IL)-6-induced MMP secretion in amniotic epithelial cells by tocilizumab. Methods: To investigate the role of MMP expressions, immunohistochemical staining was performed using membranes obtained from 10 patients with preterm premature rupture of membranes (PPROM) and from 10 patients who underwent a nonlabor cesarean section. We also investigated the regulation of MMP expression by inflammatory cytokines in human amnion cells. Results: Immunohistochemical staining showed a significantly higher expression of MMP-2 and -9 in PPROM. Treatment of cultured WISH and primary amniotic epithelial cells with 10^–8 or 10^–7M IL-6 or tumor necrosis factor (TNF)-α clearly increased the secretion of MMP-2 and -9. Treatment with 10^–8M TNF-α or IL-6 significantly increased the invasion of WISH or primary amniotic epithelial cells, respectively, compared with the control. At a low concentration of 1 μg/ml, tocilizumab (anti-human IL-6 receptor monoclonal antibody) inhibited the IL-6-induced MMP secretion. Conclusions: This paper is the 1st report of tocilizumab inhibiting IL-6-induced MMP-2 and MMP-9 secretions from human amnion cells in PPROM.

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The value of cord blood interleukin-6 levels for predicting chorioamnionitis, funisitis and neonatal infection in term premature rupture of membranes

Cited by 48 publications

References 16 publications

Microbiological study of cases of early neonatal sepsis and evaluation of the role of C-reactive protein, interleukin-6 and interleukin-8 as diagnostic biomarkers of such cases

Microbiological study of cases of early neonatal sepsis and evaluation of the role of C-reactive protein, interleukin-6 and interleukin-8 as diagnostic biomarkers of such cases

Effect of Chorioamnionitis on Early Childhood Asthma

Tocilizumab Inhibits Interleukin-6-Mediated Matrix Metalloproteinase-2 and -9 Secretions from Human Amnion Cells in Preterm Premature Rupture of Membranes

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