The value of diffusion-weighted imaging in the diagnosis of medication-related osteonecrosis of the jaws

Muraoka, Hirotaka; Ito, Kotaro; Hirahara, Naohisa; Okada, Shunya; Kondo, Takumi; Kaneda, Takashi

doi:10.1016/j.oooo.2021.04.003

Cited by 8 publications

(9 citation statements)

References 24 publications

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“…Many studies have assessed the ADC, a parameter that quantifies the water diffusion in DW-MRI, in conditions including bone marrow disease, osteoporosis, malignancy, and trauma. [14][15][16][17][18] However, to the best of our (Table 1). Region of interest (ROIs) were manually drawn on the ADC map where the bilateral parotid glands were depicted in the maximum area (Figure 1).…”

Section: Introductionmentioning

confidence: 67%

“…For many years, the clinical utility of DW-MRI has been reported in head and neck lesions. 16,17,23 In parotid glands, DW-MRI has been used to evaluate diseases such as benign and malignant tumors, and Sjögren's syndrome. 24,25 Moreover, it has been also reported that benign tumor has higher ADC values than malignant one and that patients with Sjögren's syndrome have significantly higher ADC values than healthy subjects.…”

Section: Discussionmentioning

confidence: 99%

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Diffusion‐weighted magnetic resonance imaging of parotid glands in diabetes mellitus: A preliminary study

Muraoka

Kaneda

Kondo

et al. 2023

Oral Science International

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ObjectiveThis retrospective study aimed to assess the parotid glands in diabetes mellitus (DM) using diffusion‐weighted magnetic resonance imaging (DW‐MRI).MethodsWe investigated 54 patients aged between 38 and 83 years, with DM (DM group) and without DM (control group), who underwent magnetic resonance imaging (MRI) in the facility between November 2006 and January 2021. We calculated the median apparent diffusion coefficients (ADCs) of the parotid glands in the control group and DM group. These groups were compared using the Mann–Whitney U tests. A receiver operating characteristic (ROC) curve analysis was performed to assess the ability of the ADC to predict DM. Statistical significance was set at p < 0.05.ResultsThe median ADCs of parotid grands in the control group and DM group were 0.83 × 10−3 mm2/s and 0.74 × 10−3 mm2/s, respectively (p < 0.01). ROC analysis revealed a cut‐off ADC value of 0.81 to distinguish between the control and DM group. Sensitivity, specificity, accuracy, and area under the ROC curve were 0.7, 0.67, 0.69, and 0.71, respectively.ConclusionThe ADC was significantly higher in DM groups than in the control group. This suggests that DW‐MRI may be able to quantitatively distinguish parotid glands between normal and DM patients.

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Section: Introductionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Diffusion‐weighted magnetic resonance imaging of parotid glands in diabetes mellitus: A preliminary study

Muraoka

Kaneda

Kondo

et al. 2023

Oral Science International

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“…Nach Anwendung der Ausschlusskriterien waren noch 7 Studien zur Auswertung geeignet (Tab. 4 ; [ 7 , 9 , 18 , 21 , 22 , 40 , 44 ]). Die meisten Studien zur Diagnostik untersuchten die Ergebnisqualität unterschiedlicher MRT-Verfahren und nuklearmedizinischer Diagnostik in der Differenzierung zwischen MRONJ und gesunden Knochenarealen oder von MRONJ im Unterschied zu anderen entzündlichen Erkrankungen der Kieferknochen.…”

Section: Ergebnisseunclassified

“…B. Orthopantomogramm), Schnittbildverfahren (DVT, CT, MRT) und nuklearmedizinische Verfahren zum Einsatz [ 9 ]. Die neuesten Studien untersuchen die Verfeinerung der diagnostischen Aussagekraft bereits bekannter Techniken [ 9 , 18 , 21 , 40 , 44 ].…”

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Management von medikamentenassoziierten Kiefernekrosen – Ergebnisse einer Literaturanalyse neuester Studien im Vergleich zu bewährten Strategien

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Pautke³

et al. 2022

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Zusammenfassung Hintergrund Antiresorptiva gehören weltweit zu den am häufigsten applizierten Arzneimitteln. Ihr Haupteinsatzbereich liegt in der Osteologie und Onkologie. Trotz allgemein guter Verträglichkeit treten bei Patienten unter Therapie unerwünschte Arzneimittelwirkungen (UAW) auf. Eine spezifische UAW im Bereich der Kiefer ist die sog. medikamentenassoziierte Osteonekrose („medication-related osteonecrosis of the jaw“, MRONJ) der Kiefer. Ziel der Arbeit Diese Arbeit stellt neuesten Entwicklungen in Ätiologie, Diagnostik und Therapie der MRONJ im Vergleich zu bereits bestehenden Erkenntnissen zusammen. Methodik Es wurde eine systematische Literaturübersicht der Jahre 2016–2021 zu diesem Thema durchgeführt. Prospektive Therapiestudien, Diagnostikstudien mit Vergleichsgruppe und innovative Studien zur Pathogenese der MRONJ wurden eingeschlossen und nach den MINORS-Kriterien („methodological index for non-randomized studies“) bewertet. Ergebnisse und Diskussion Die MRONJ tritt bei ca. 2–12 % der Patienten, die aus onkologischer Indikation mit Antiresorptiva behandelt werden, auf (osteologische Indikation ca. 0,1–1 %). Die Therapie der MRONJ sollte frühzeitig und operativ erfolgen. Die Heilungsrate ist bei einem operativen Therapieansatz mit über 85 % sehr gut.

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“…[13][14][15][16][17] In recent years, there have been reports on quantitative evaluation of medication-related osteonecrosis of the jaw (MRONJ) using DWI. 18,19 ASO can be easy to diagnose by its clinical symptoms, but its distinction from CSO, which often presents with similar imaging findings, and refractory CDSO is important for determining subsequent treatment strategies. Moreover, early diagnosis and treatment are important because CDSO, although rare, is more refractory compared to suppurative osteomyelitis.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Efficacy of Diffusion-weighted Imaging in Distinguishing Chronic Diffuse Sclerosing Osteomyelitis from Suppurative Osteomyelitis of the Mandible

et al. 2023

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Purpose: Chronic diffuse sclerosing osteomyelitis (CDSO) is a non-suppurative inflammatory bone disease diagnosed based on combined clinical, histopathological, and radiological findings. Accurate diagnosis is important since CDSO is more refractory to treatment than suppurative osteomyelitis. The purpose of this study was to determine the diagnostic efficacy of diffusion-weighted imaging (DWI) in the quantitative assessment of CDSO to distinguish it from acute suppurative osteomyelitis (ASO) and chronic suppurative osteomyelitis (CSO) of the mandible. Methods: Using a retrospective cohort study design, we analyzed MRI data of 6 patients with CDSO and 34 patients with ASO and CSO. The mean apparent diffusion coefficient (ADC) values of the three groups (CDSO, ASO, and CSO groups) were calculated, and differences were analyzed using Kruskal-Wallis and post-hoc Mann-Whitney tests with Bonferroni adjustments. We performed a receiver operating characteristic (ROC) curve analysis to evaluate the ability of the ADC to predict CDSO. P < 0.05 was considered statistically significant. Results: The mean ADCs in the CDSO, ASO, and CSO groups were 1.22 ± 0.04 × 10 -3 mm 2 /s, 1.28 ± 0.08 × 10 -3 mm 2 /s, and 1.06 ± 0.09 × 10 -3 mm 2 /s, respectively. Significant differences were observed between the ASO and CSO groups (P < 0.001) and CSO and CDSO groups (P < 0.01). However, there was no significant difference between the ASO and CDSO groups (P = 0.21). The ROC analysis revealed a cut-off ADC value of 1.19 for distinguishing the CSO group from the CDSO group. Sensitivity, specificity, accuracy, and area under the ROC curve were 1.0, 0.92, 0, 95, and 0.94, respectively. Conclusion:The results suggest that ADC may be useful in distinguishing CDSO from mandibular suppurative osteomyelitis.

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The value of diffusion-weighted imaging in the diagnosis of medication-related osteonecrosis of the jaws

Cited by 8 publications

References 24 publications

Diffusion‐weighted magnetic resonance imaging of parotid glands in diabetes mellitus: A preliminary study

Diffusion‐weighted magnetic resonance imaging of parotid glands in diabetes mellitus: A preliminary study

Management von medikamentenassoziierten Kiefernekrosen – Ergebnisse einer Literaturanalyse neuester Studien im Vergleich zu bewährten Strategien

Diagnostic Efficacy of Diffusion-weighted Imaging in Distinguishing Chronic Diffuse Sclerosing Osteomyelitis from Suppurative Osteomyelitis of the Mandible

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