The value of diffusion-weighted MRI to evaluate the response to radiochemotherapy for cervical cancer

A literature review of the association between diffusion-weighted MRI derived apparent diffusion coefficient and tumour aggressiveness in pelvic cancer

“…In patients achieving complete response, the increase in ADC was significantly larger as early as 2 weeks after start of treatment than in patients who subsequently did not [37][38][39], so that change in ADC at an early time point holds potential as a biomarker of likely aggressive, poorly responding disease.…”

Can diffusion-weighted magnetic resonance imaging predict tumor recurrence of uterine cervical cancer after concurrent chemoradiotherapy?

“…Several studies have reported the role of DWI in predicting or monitoring therapeutic response to CCRT in uterine cervical cancer, particularly focusing on complete or partial response after therapy [4,10,11]. A systemic review demonstrated that as apparent diffusion coefficient (ADC) of pretherapy and posttherapy in uterine cervical cancer was compared, complete responders had higher increase than partial responders or nonresponders [12].…”

Value of apparent diffusion coefficient (ADC) in assessing radiotherapy and chemotherapy success in cervical cancer

“…Initially, we retrieved 196 articles by electronic database search. After screening titles and abstracts of all the retrieved articles, we systematically reviewed 101 full text articles, and identified 16 articles based on a careful assessment of quality, relevance and completeness of data[2][3][4]10,22,23,[28][29][30][31][32][33][34][35][36][37][38][39]. The included studies consisted of a combined total of 517 patients A B Subgroup analysis by ethnicity and b value for the differences in diffusion-weighted magnetic resonance imaging for predicting the efficacy of radiotherapy and chemotherapy for cervical cancer (A: ethnicity, B: b value).…”