The Value of Dynamic MRI Studies in Parotid Tumors

Alibek, Sedat; Zenk, Johannes; Bozzato, Alessandro; Lell, Michael; Grunewald, M.; Anders, Katharina; Rabe, Christina; Iro, Heinrich; Bautz, W.; Greeß, H.

doi:10.1016/j.acra.2007.03.004

Cited by 53 publications

(24 citation statements)

References 26 publications

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“…To obtain accurate TICs, a dynamic MRI sequence with high temporal resolution should be used. 6,16 However, the temporal resolution in most of the previous studies was relatively low (15-60 s), [8][9][10][11][12]14,[17][18][19][20] which may partly explain the inconsistencies between reports.…”

Section: The Authors Phong Dai Lam and Ami Kuribayashi Equally Contrimentioning

confidence: 44%

“…12 As mentioned above, the efficacy of DCE-MRI in differentiating malignant from benign salivary gland tumours has not yet been fully established. One of the reasons for the inconsistencies among past studies might be their small sample sizes; with one exception, 6 each analysed only 20-50 cases. [8][9][10][11][12][13][14][15][17][18][19][20] Another reason may be the differences in imaging protocols used to obtain DCE-MRI data sets.…”

Section: Discussionmentioning

confidence: 99%

“…6,16 Furthermore, evaluating differences in WR among different types of tumours requires a sufficiently long total scan time. 16 However, in most of the past studies on DCE-MRI of salivary gland tumours, the interval between sequential MR images ranged from 15 to 60 s. [8][9][10][11][12]14,[17][18][19][20] Although this duration was 10 s in a few studies, 6,13,15 which, to our knowledge, was the shortest interval employed, the total scan time in these studies was quite short, at 100 6 or 180 s. 13,15 By contrast, we applied fast DCE-MRI with high temporal resolution and sufficient examination time to 98 cases with salivary gland tumours. Specifically, MR images were sequentially obtained at 5-s intervals for 370 s. Furthermore, in all cases, contrast material was administered at a rate of 3 ml s 21 using a power injector, followed by a 20-ml saline flush.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, the sensitivity of conventional MRI in predicting malignancy is known to be quite low. [5][6][7] Several researchers reported that time-signal intensity curves (TICs) obtained by dynamic contrast-enhanced MRI (DCE-MRI) were useful in the differential diagnosis of salivary gland tumours and that the TIC characterized by early enhancement and low washout was associated with malignancy. 4,[8][9][10][11][12][13][14][15] However, the specific criteria involved, that is, the definition of and thresholds for the time to peak enhancement and the washout ratio (WR), have varied widely among studies.…”

Section: The Authors Phong Dai Lam and Ami Kuribayashi Equally Contrimentioning

confidence: 99%

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Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution

Lam¹,

Kuribayashi²,

Imaizumi³

et al. 2015

BJR

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The authors Phong Dai Lam and Ami Kuribayashi equally contributed to this work.Objective: To determine the optimal diagnostic criterion of dynamic contrast-enhanced MRI (DCE-MRI) for predicting salivary gland malignancy using a dynamic sequence with high temporal resolution, as well as the accuracy of this technique. Methods: The DCE-MRI findings of 98 salivary gland tumours (74 benign and 24 malignant) were reviewed. MR images were sequentially obtained at 5-s intervals for 370 s. Two parameters, peak time and washout ratio (WR) were determined from the time-signal intensity curve. The optimal thresholds of these parameters for differentiating benign and malignant tumours were determined, along with the diagnostic accuracy of the criterion using these thresholds. Results: A peak time of 150 s and a WR of 30% were identified as optimal thresholds. As the criterion for malignancy, the combination of peak time ,150 s and WR ,30% provided a sensitivity of 79% (19/24), specificity of 95% (70/74) and an overall accuracy of 91% (89/98). Three of the five false-negative cases were malignant lymphomas of the parotid gland. Conclusion: Peak time ,150 s with WR ,30% comprised the optimal diagnostic criterion in predicting salivary gland malignancy, providing a sensitivity of 79% and specificity of 95%. The use of high temporal resolution might improve the accuracy of DCE-MRI. Advances in knowledge: Although several studies have reported the usefulness of DCE-MRI in the differential diagnosis of salivary gland tumours, the specific diagnostic criteria employed have differed widely. We determined the optimal criterion and its accuracy using a dynamic sequence with high temporal resolution.

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Section: The Authors Phong Dai Lam and Ami Kuribayashi Equally Contrimentioning

confidence: 44%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: The Authors Phong Dai Lam and Ami Kuribayashi Equally Contrimentioning

confidence: 99%

See 2 more Smart Citations

Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution

Lam¹,

Kuribayashi²,

Imaizumi³

et al. 2015

BJR

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“…[9][10][11] Recently, few studies have assessed the role of dynamic contrast-enhanced MRI (DCE-MRI) in differentiation of SGTs with several of them showing promising results. [12][13][14][15][16][17] This study was designed to evaluate the role of DCE-MRI using a 3-T magnet for differentiation of major salivary gland neoplasms.…”

Section: Introductionmentioning

confidence: 99%

Dynamic contrast-enhanced MRI for differentiation of major salivary glands neoplasms, a 3-T MRI study

Aghaghazvini

Salahshour²,

Yazdani³

et al. 2015

Dentomaxillofacial Radiology

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Objectives: Pre-operative differentiation of salivary gland neoplasms is of great importance. This study was designed to evaluate the use of dynamic contrast-enhanced MRI (DCE-MRI) for differentiation between malignant, Warthin and benign non-Warthin (BNW) neoplasms of major salivary glands. Methods: 46 major salivary gland tumours (SGTs) underwent pre-operative DCE-MRI. Postsurgical histopathological evaluation showed 30 BNW, 6 Warthin and 10 malignant tumours. Time-signal intensity curves (TICs) were categorized as (a) Tpeak .43 s and washout ratio at 180 s (WR180) ,4.6%; (b) Tpeak ,43 s and WR .22%; (c) Tpeak .43 s and WR180 5 4.6-22.0% Results: Accuracy of Tpeak was 98.9% for differentiation between BNW and Warthin tumours, 83.7% between BNW and malignant and 80% between malignant and Warthin tumours. All Warthin tumours showed Tpeak #43 s, while one BNW had Tpeak ,43 s. A Tpeak ,63.5 s differentiated 8/10 (80%) malignant tumours from BNW tumours, whereas 4/30 of BNW tumours had a Tpeak ,63.5 s. Two malignant tumours had Tpeak ,43 s. WR180 had an accuracy of 100% for differentiation between Warthin and BNW tumours, 87.3% between BNW and malignant, and 93.3% between Warthin and malignant tumours. 29 (96.7%) BNW tumours had a washout ,4.60%, while 8 (80%) malignant tumours had a washout .4.60%. All Warthin tumours had a WR180 .22%, while two malignant tumours had a WR180 .22%. 29/30 of BNW tumours demonstrated TIC curve Type A and 1 tumour demonstrated Type C. 6/10 of malignant tumours had TIC Type C, 2 had TIC Type A and 2 Type B. All Warthin tumours were categorized as Type B. Conclusions: This study showed that DCE-MRI could be helpful in pre-operative differentiation of SGTs; especially for discrimination between Warthin and BNW tumours.

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Diagnostic Imaging of Salivary Gland Pathology

Jacob

2015

Salivary Gland Pathology

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The Value of Dynamic MRI Studies in Parotid Tumors

Cited by 53 publications

References 26 publications

Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution

Differentiating benign and malignant salivary gland tumours: diagnostic criteria and the accuracy of dynamic contrast-enhanced MRI with high temporal resolution

Dynamic contrast-enhanced MRI for differentiation of major salivary glands neoplasms, a 3-T MRI study

Diagnostic Imaging of Salivary Gland Pathology

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