The value of electrochemical skin conductance measurement by Sudoscan® for assessing autonomic dysfunction in peripheral neuropathies beyond diabetes

Lefaucheur, Jean‐Pascal

doi:10.1016/j.neucli.2023.102859

Cited by 8 publications

(4 citation statements)

References 70 publications

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“…Our study was the first one which evaluated the role of Sudoscan in the diagnosis of peripheral neuropathy in IBD patients. Sudoscan is a simple and fast method based on the mechanisms of reverse iontophoresis and chronoamperometry in the sympathetic innervation of the sweat glands of the extremities [29]. The role of sudoscan is in the diagnosis of peripheral neuropathy, specifically its autonomic component (sudomotor function).…”

Section: Discussionmentioning

confidence: 99%

“…In our study, thirty eligible patients (15 men and 15 women) with CD were enrolled. The median patient age was 46 (range 30-62 years) and median patient body mass index was 25 (range [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. In terms of other common diseases only 2 patients (6.7%) reported arterial hypertension and no other serious comorbidities (such as thyroid gland diseases, ischemic…”

Section: Patient Demographics (Table 1)mentioning

confidence: 99%

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Dysfunction of peripheral somatic and autonomic nervous system in patients with severe forms of Crohn’s disease on biological therapy with TNFα inhibitors–A single center study

Wasserbauer,

Mala,

Stechova

et al. 2023

PLoS ONE

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Objective Crohn’s disease (CD) can be associated with a wide range of extraintestinal manifestations (EIMs), including neurological ones. Published studies differ in their conclusions about the epidemiology and etiopathogenesis of neurological EIMs. The aims of this study were to demonstrate the presence and find risk factors of peripheral (somatic and autonomic) neuropathy patients with severe CD on anti-TNFα biological therapy. Material and methods A clinical examination focusing on detection of peripheral sensor-motor nervous dysfunction (including Sudoscan) and examination of autonomic nervous system dysfunction (using Ewing´s battery tests and spectral analysis) together with laboratory tests and collection of demographic data followed by administration of questionnaires were performed on a total of 30 neurologically asymptomatic outpatients with severe CD on anti-TNFα biological therapy. Results Peripheral sensor-motor nervous function via clinical neurological examination was pathological in 36.7% and Sudoscan in 33.3% of cases. Statistically significant associations between vibration perception test and age, CD and biological therapy duration, body mass index and Crohn’s Disease Activity Index were proved while statistically significant associations between temperature perception test and age and BMI were proved as well. Additionally, a decrease of total protein in a patient´s serum below the physiological cut-off in the 6 months prior to measurement was associated with a pathological result of a Sudoscan. Cardiovascular autonomic neuropathy based on Ewing´s battery tests was present in 56.7% of patients, no statistically significant risk factors were found. Our peripheral neuropathy questionnaire correlated with the results of the Sudoscan test and some tests of the clinical examination of peripheral sensor-motor nervous function (discriminatory contact perception test, temperature perception test). Conclusions This study demonstrated a relatively high prevalence of peripheral (especially autonomic) neuropathy and verified some risk factors for the development of peripheral somatic neuropathy in asymptomatic patients with severe form of CD on anti-TNFα biological therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Patient Demographics (Table 1)mentioning

confidence: 99%

Dysfunction of peripheral somatic and autonomic nervous system in patients with severe forms of Crohn’s disease on biological therapy with TNFα inhibitors–A single center study

Wasserbauer,

Mala,

Stechova

et al. 2023

PLoS ONE

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“…Tailor treatment plans to the individual’s needs, considering factors like age, life expectancy, comorbidities, and hypoglycemia risk. [95–102]…”

Section: Monitoring For Complicationsmentioning

confidence: 99%

Management of diabetes mellitus patients with sickle cell anemia: Challenges and therapeutic approaches

Obeagu,

Obeagu

2024

Medicine

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The coexistence of diabetes mellitus (DM) and sickle cell anemia (SCA) poses significant challenges in clinical management due to the complex interactions and overlapping complications associated with both conditions. Managing diabetes in individuals with SCA requires a comprehensive approach that addresses the unique physiological and pathological aspects of both diseases. This paper reviews the challenges encountered in the management of DM in patients with SCA and explores therapeutic strategies and approaches to optimize patient care. Challenges in the management of DM in individuals with SCA stem from several factors, including the impact of hemoglobin variants on glycemic control assessment, increased susceptibility to infections, altered immune response, and complications associated with both diseases. Moreover, the coexistence of SCA and DM heightens the susceptibility to infections due to compromised immune function, emphasizing the need for vigilant preventive measures, including vaccinations and close monitoring for infectious complications. Close collaboration among healthcare providers specializing in diabetes, hematology, and other relevant fields is crucial for developing comprehensive care plans. Individualized treatment strategies that balance glycemic control, pain management, and preventive care are essential to mitigate complications and optimize the overall health outcomes of patients with both DM and SCA. In conclusion, managing diabetes in the context of SCA necessitates a nuanced and patient-centered approach. By addressing the challenges and employing tailored therapeutic strategies, healthcare providers can improve the quality of life and health outcomes for individuals affected by both conditions.

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“…Electrochemical skin conductance (ESC) assesses peripheral autonomic nervous system by measuring the sudomotor function and has been successfully implemented into clinical practice [1][2][3][4][5][6][7][8][9] . Normative values, defined from a large clinical trial consisting of thousands of healthy subjects 10 are currently in use to define thresholds for health and disease for clinical and research purposes.…”

Section: Introductionmentioning

confidence: 99%

Chronobiological, age and sex effects on Electrochemical Skin Conductance: results from a large observational data set

Vittrant,

Courrier,

Mauries

et al. 2024

Preprint

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This study presents a comprehensive analysis of electrochemical skin conductance (ESC) values collected from over 1.9 million measurements using Withings Body Scan and Body Comp scales. Aimed at establishing normative values for ESC, this research incorporates a large, global dataset to explore the influence of age, sex, and circadian and seasonal variations on sudomotor function. Our findings reveal that ESC values exhibit a small, gradual decline with age and are potentially slightly lower in women compared to men. Notably, we identified significant daily and annual patterns in ESC values, suggesting the influence of chronobiological factors. By employing both univariate and multivariate regression models, including an approach using sinusoidal variations, we refined our understanding of these patterns. The study underscores the importance of considering these variations in clinical and home monitoring of ESC, offering new insights into peripheral neuronal aging and the potential for ESC as a biomarker for sympathetic and parasympathetic nervous system balance. Our work establishes a crucial reference for interpreting ESC measurements, taking into account demographic, biological, and seasonal variations, and highlights the need for further research to explore the clinical implications of these findings.

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The value of electrochemical skin conductance measurement by Sudoscan® for assessing autonomic dysfunction in peripheral neuropathies beyond diabetes

Cited by 8 publications

References 70 publications

Dysfunction of peripheral somatic and autonomic nervous system in patients with severe forms of Crohn’s disease on biological therapy with TNFα inhibitors–A single center study

Dysfunction of peripheral somatic and autonomic nervous system in patients with severe forms of Crohn’s disease on biological therapy with TNFα inhibitors–A single center study

Management of diabetes mellitus patients with sickle cell anemia: Challenges and therapeutic approaches

Chronobiological, age and sex effects on Electrochemical Skin Conductance: results from a large observational data set

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