The value of eosinophil count in the diagnosis of preeclampsia among pregnant women attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia, 2021

Abstract

Background Currently, studies showed that eosinophil count had clinical significance in the diagnosis and prognosis of diseases. But, the clinical significance of eosinophil count in pregnancy specifically in preeclampsia (PE) is not well studied. The main objective of the present study was to assess the diagnosis value of eosinophils counts among pregnant women with PE. Methods A comparative cross-sectional study was conducted on a total of 126 pregnant women at the University of Gondar Comprehensive Specialized Hospital, using a convenient sampling technique. Socio-demographic and clinical data were collected by questionnaire and datasheet from patient’s charts, respectively. A total of six ml of blood was collected from each study participant; three ml for complete cell count analysis using Sysmex XS-500i hematology analyzer and three ml for liver function tests using Humastar 200 chemistry analyzer. The data were entered into Epi-data and exported to SPSS 20 for analysis. The independent t-test was used for normally distributed data and, the Mann–Whitney U test was used for non-normally distributed data. Binary logistic regression and receiver operative curve analyses were also done to assess the diagnosis value of eosinophils count. P-value < 0.05 was considered statistically significant. Results The eosinophils count of PE pregnant women were significantly lower than the normotensive (NT) pregnant women (median (IQR): 50 (10—200) vs. 120 (60 – 270); (p = 0.002). The eosinophil count ≤ 55 cells/µL had an AUC of 0.66 (95% CI; 0.56—0.75) for diagnosis of PE with a sensitivity of 50.8%, specificity of 77.8%, and positive and negative predictive value of 69.6% and 61.3%, respectively. The abnormal AST and ALT results were significantly higher among PE pregnant women compared to NT pregnant women (AOR: 14.86; 95% CI: 4.97—44.4 and Fischer exact test p-value = 0.001, respectively). Conclusion The eosinophil count ≤ 55cells/µl had a reasonable/acceptable AUC which may use in the diagnosis of PE. AST and ALT were also significantly higher in PE pregnant women compared to NT pregnant women. Multicenter longitudinal studies with a large sample size are recommended to verify the role of eosinophil count in the diagnosis of PE.

Comparison of blood ΒHBA measurement devices for diagnosis of subclinical pregnancy toxaemia in sheep: A field study

“…Production traits are affected by congenital diseases (Koca et al, 2024), individual genetic differences (Turgut et al, 2023;, and management (Koca et al, 2023;Komprej et al, 2012) acid profiles (Uztimür et al, 2024), acute phase proteins (Darwish & El-Ebissy, 2019), eosinophil count and eosinophil-based complete blood cell (Gelaw et al, 2022;Tanacan et al, 2023). Together with this, serum or blood BHBA levels are still accepted as a reliable biomarker in the diagnosis of PT in small ruminants.…”

“…The novel biomarkers are suggested in the diagnosis of PT. Some of these markers are circulating free amino acid profiles (Uztimür et al., 2024), acute phase proteins (Darwish & El‐Ebissy, 2019), eosinophil count and eosinophil‐based complete blood cell (Gelaw et al., 2022; Tanacan et al., 2023). Together with this, serum or blood BHBA levels are still accepted as a reliable biomarker in the diagnosis of PT in small ruminants.…”

Coagulation Factors and Natural Anticoagulants as Surrogate Markers of Preeclampsia and Its Subtypes: A Case–Control Study in a Ghanaian Population

“… 17 As a result, various studies have been done to evaluate the potential detection or prediction of PE utilizing CBC indices. 39 – 41 Derangements in the intrinsic and extrinsic coagulation pathways, as well as decreased levels of coagulation inhibitors, can also cause hypercoagulation. 42 This case–control study aimed to assess plasma levels of coagulation parameters and their natural inhibitors as potential predictive markers of PE.…”

Diagnostic Approach to Elevated Liver Function Tests during Pregnancy: A Pragmatic Narrative Review

“…From a diagnostic point of view, elevated AST/ALT levels are found in 20–50% of the patients [ 2 , 44 ], with mean values of 40–100 IU/L [ 67 , 68 ] (usually 2–5-fold increase × ULN), and as stated above, contribute to the establishment of a PE diagnosis in the presence of hypertension. Patients with HELLP usually present mean AST/ALT values of 300–500 IU/L [ 69 , 70 ] that can go up to 30 × ULN, and not infrequently (15%), jaundice [ 71 ].…”