The value of epidural magnesium sulfate as an adjuvant to bupivacaine and fentanyl for labor analgesia

Hasanein, Riham; ElSayed, Wael M.; Khalil, Mohamed A.

doi:10.1016/j.egja.2013.02.002

Cited by 23 publications

(27 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[24] Riham et al showed that epidural single dose magnesium sulphate when added to bupivacaine in labour analgesia resulted in significantly faster onset and longer duration of action of epidural analgesia compared to bupivacaine and fentanyl combine. [25] It was observed in the present study that addition of 50mg of MgSO 4 to 0.5% bupivacaine administered epidurally reduces the onset of sensory block compared to epidural 0.5% bupivacaine with clonidine, which was statistically significant. There were no significant change in blood pressure, pulse rate and respiratory rate in both groups.…”

Section: Discussionsupporting

confidence: 56%

Comparative Study of Clonidine and Magnesium Sulfate Used as Adjuvant to Epidural Bupivacaine in Orthopedic Lower Limb Surgery

Pradhan¹,

Nayak²,

Dash³

et al. 2016

AIMDR

View full text Add to dashboard Cite

Background: A lot of researches have been done to find an ideal adjuvant to bupivacaine in epidural anaesthesia that inhibits intra and post operative pain and prolongs the duration of anaesthesia without any side effects. Study regarding antinociceptive effect of magnesium in epidural route is very limited. Aim: This study was done to evaluate the onset, extent and duration of sensory and motor block and side effects of clonidine and magnesium sulfate when used as an adjuvant to bupivacaine in epidural anaesthesia in lower limb orthopedic surgery. Methods: A prospective randomized double blind study was conducted on 60 patients of American society of anaesthesiologists status I and II, posted for lower limb orthopedic surgery. All patients were randomly allocated into two groups of 30 each; group I was bupivacaineclonidine group (BC) and group II was bupivacaine -magnesium sulfate group (BM). Group I (BC) patients received 16 ml of 0.5% bupivacaine and clonidine 2mcg/kg. Group II (BM) patients received 16 ml of 0.5% bupivacaine and magnesium sulfate (50 mg). The onset, extent, duration of sensory and motor blocks and side effects were recorded. Results: Magnesium sulfate had a visible edge over clonidine as it enabled an earlier onset of sensory block but duration of analgesia was more in clonidine group. Sedation scores were statistically significant with BC group in comparison to BM group. Both groups were haemodynamically stable in peri and post-operative period. Conclusion: Magnesium sulfate was a better alternative to clonidine as an adjuvant to bupivacaine in epidural anaesthesia in orthopedic lower limb surgeries for rapid onset of action but clonidine has prolonged duration of action.

show abstract

Section: Discussionsupporting

confidence: 56%

Comparative Study of Clonidine and Magnesium Sulfate Used as Adjuvant to Epidural Bupivacaine in Orthopedic Lower Limb Surgery

Pradhan¹,

Nayak²,

Dash³

et al. 2016

AIMDR

View full text Add to dashboard Cite

show abstract

“…[15] It was observed in the present study that addition of 50mg of MgSO4 to 0.5% bupivacaine administered epidurally reduces the onset of sensory and motor block compared to epidural 0.5% bupivacaine with clonidine which was statistically significant. There were no significant change in blood pressure, pulse rate and respiratory rate in both groups.…”

Section: Section: Anaesthesiasupporting

confidence: 52%

Comparative Study Of Clonidine And Magnesium Sulfate Used As Adjuvant To Epidural Bupivacaine In Lower Abdominal Surgery

Mohanty¹,

Pradhan²

2017

AIMDR

View full text Add to dashboard Cite

show abstract

“…This study result was comparable to previously done studies. 11,6 Time of onset of motor block in group RFM (8.88±1.71 minutes) was faster than Group RF (15.65±3.34 minutes) and R (24.4±3.71 minutes) which is statistically significant (p<0.001). In a previous study it was found that onset of motor blockade was 16.92±3.84 minute with epidural 20 ml ropivacaine 0.75% with 75 g fentanyl in lower abdominal and lower limb surgeries.…”

Section: Discussionmentioning

confidence: 80%

“…This study result was similar similar to previous studies. 9,6 Mean Time of onset of T10 sensory block was fastest in Group RFM (7.28±1.34 minutes) as compared to Group R (12.45±2.11 minutes) and RF (11.15±2.47 minutes) and this was statistically significant (p<0.001), showing rapid onset of action produced by magnesium sulfate. This result was comparable to a previous study using bupivacaine and magnesium in epidural route.…”

Section: Discussionmentioning

confidence: 88%

“…Based on a previous study and considering 95% confidence interval and 80% power of study and adding for contingency of 10% a minimal sample size of 20 patients was found necessary for each group. 6 Inclusion and exclusion criteria: 60 Patients between 18 and 60 years of age of the American Society of Anesthesiologist (ASA) physical status class I and II, of either sex, posted for lower limb surgery were included in the study. Any contraindication to epidural anesthesia as local site infection, bleeding tendencies, vertebral anomalies, sepsis, raised intracranial pressure, allergy to local anesthetic agents, peripheral neuropathy, patient's refusal and physical dependence on narcotics were excluded from the study.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Comparative study of ropivacaine with ropivacaine-fentanyl and ropivacaine-fentanyl- magnesium sulfate in epidural anesthesia for lower limb surgeries

Gupta¹,

Tiwari

Kapoor

et al. 2018

Int Surg J

View full text Add to dashboard Cite

Background: Epidural anesthesia is currently one of the most used technique for patients undergoing lower limb surgery. Dose sparing action of one adjuvant for another in epidural anesthesia with local anesthetic drugs for providing quality care to the patient remains controversial. Aims of the present study was to compare and study the properties 0.75% Ropivacaine alone (R) with 0.75% Ropivacaine-Fentanyl (RF) and 0.75% Ropivacaine-Fentanyl-Magnesium sulfate (RFM) in epidural anesthesia for lower limb surgeries. Study design was prospective randomized double blind study.Methods: Patients between 18-60 years of age of ASA physical status class I and II undergoing lower limb surgeries were randomly allocated into 3 groups of 20 each. Total volume in epidural space given was 17ml in all 3 groups. Group R (n=20) received 15ml of 0.75% Ropivacaine with 2ml of normal saline, Group RF (n=20) received 15ml of 0.75% Ropivacaine with 50mg of fentanyl (1ml) and 1ml normal saline and Group RFM (n=20) received 15ml of 0.75% Ropivacaine with 50mg of fentanyl (1ml) and 100mg MgSO4 (1ml). Patients were then studied for hemodynamic profile, various block characteristics and side effects. Statistical analysis used was ANOVA, paired t-test, Chi-square and post hoc test were used. P <0.05 was considered significant.Results: All three groups had stable hemodynamic parameters with Group RFM showing better block characteristics (p <0.001) in terms of time for achieving onset of analgesia, time for achieving T10 sensory blockade, time for requirement of first epidural top up, time for achieving motor Blockade, time for complete recovery of motor blockade with no significant differences in the side effect profile.Conclusions: Epidural anesthesia for lower limb surgeries may have better block characteristic parameters if a combination of Ropivacaine-fentanyl-magnesium sulphate is used in comparison with ropivacaine-fentanyl or ropivacaine alone.

show abstract

The value of epidural magnesium sulfate as an adjuvant to bupivacaine and fentanyl for labor analgesia

Cited by 23 publications

References 21 publications

Comparative Study of Clonidine and Magnesium Sulfate Used as Adjuvant to Epidural Bupivacaine in Orthopedic Lower Limb Surgery

Comparative Study of Clonidine and Magnesium Sulfate Used as Adjuvant to Epidural Bupivacaine in Orthopedic Lower Limb Surgery

Comparative Study Of Clonidine And Magnesium Sulfate Used As Adjuvant To Epidural Bupivacaine In Lower Abdominal Surgery

Comparative study of ropivacaine with ropivacaine-fentanyl and ropivacaine-fentanyl- magnesium sulfate in epidural anesthesia for lower limb surgeries

Contact Info

Product

Resources

About