The value of FDG-PET in patients with painful total knee arthroplasty

Stumpe, Katrin D. M.; Roméro, J.; Ziegler, Oliver; Kamel, Emad Zarief; Schulthess, Gustav K. von; Strobel, Klaus; Hodler, Juerg

doi:10.1007/s00259-006-0127-1

Cited by 33 publications

(16 citation statements)

References 34 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, 20 studies remained for possible inclusion and were retrieved in full-text version. After reviewing the full article, five articles [18,21,22,25,26] were excluded because the same data were used in another article comprising a larger number of patients, one article was excluded because it did not investigate the diagnostic performance of FDG-PET in detecting prosthetic hip or knee joint infection [14], one article [16] was excluded because the same data were used in another article providing more study details, one article [29] was excluded because less than 15 patients with hip and/or knee prosthesis were investigated, and one article [31] was excluded because it appeared to be an abstract only. Screening references of the remaining articles resulted in one other potentially relevant article [32].…”

Section: Literature Searchmentioning

confidence: 99%

“…Reviewing titles and abstracts from PubMed/MEDLINE revealed 20 articles potentially eligible for inclusion [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]. Reviewing titles and abstracts from Embase revealed 17 articles potentially eligible for inclusion, which were all already identified by the PubMed/MEDLINE search.…”

Section: Literature Searchmentioning

confidence: 99%

See 1 more Smart Citation

FDG-PET for diagnosing prosthetic joint infection: systematic review and metaanalysis

Kwee

Kwee²,

Alavi

2008

Eur J Nucl Med Mol Imaging

131

View full text Add to dashboard Cite

Purpose The aim of this study was to systematically review and metaanalyze published data on the diagnostic performance of 18 F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in detecting prosthetic hip or knee joint infection. Methods A systematic search for relevant studies was performed of the PubMed/MEDLINE and Embase databases. Two reviewers independently assessed the methodological quality of each study. A metaanalysis of the reported sensitivity and specificity of each study was performed. Subgroup analyses were performed if results of individual studies were heterogeneous. Results The inclusion criteria were met by 11 studies; there was a total sample size of 635 prostheses. Overall, the studies had good methodological quality. Pooled sensitivity and specificity of FDG-PET for the detection of prosthetic hip or knee joint infection were 82.1% (95%CI=68.0-90.8%) and 86.6% (95%CI=79.7-91.4%), respectively. Heterogeneity among the results of individual studies was present (I 2 =68.8%). Diagnostic performance was influenced by type of joint prostheses (hip prostheses vs. knee prostheses) and type of reconstruction method used (filtered back vs. iterative) (p=0.0164 and p=0.0235, respectively). Conclusion In this metaanalysis, overall diagnostic performance of FDG-PET was moderate to high. Caution is warranted, however, because results of individual studies were heterogeneous and could not be fully explored. Future studies should further explore potential causes of heterogeneity and validate the use of FDG-PET for diagnosing prosthetic joint infection.

show abstract

Section: Literature Searchmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

FDG-PET for diagnosing prosthetic joint infection: systematic review and metaanalysis

Kwee

Kwee²,

Alavi

2008

Eur J Nucl Med Mol Imaging

131

View full text Add to dashboard Cite

show abstract

“…In another study performed by our group, FDG uptake was examined in 28 patients with painful total knee arthroplasty, with uptake found to be related to the location of soft-tissue pain [39]. Increased FDG uptake was found in the synovial membrane in all patients except one patient independent of the clinical diagnosis (Fig.…”

Section: Prosthetic-joint Infectionmentioning

confidence: 98%

Radionuclide Imaging of Musculoskeletal Infections

Stumpe

2009

Musculoskeletal Diseases 2009–2012

Self Cite

View full text Add to dashboard Cite

“…The results of other investigations have been less satisfactory (71)(72)(73)(74)(75)(76)(77) (73) and that periprosthetic 18 F-FDG accumulation around a knee arthroplasty was not specific for infection (74). Delank et al (75) concluded that 18 F-FDG PET was not specific for lower-extremity joint arthroplasty infection.…”

Section: Prosthetic Joint Infectionmentioning

confidence: 99%

Radionuclide Imaging of Musculoskeletal Infection: A Review

Palestro

2016

J Nucl Med

View full text Add to dashboard Cite

Learning Objectives: On successful completion of this activity, participants should be able to describe (1) the principle of combined labeled leukocyte/marrow imaging; (2) at least one advantage of 18 F-FDG PET or PET/CT over MRI for diagnosing spondylodiskitis; and (3) at least one advantage of SPECT/CT over planar imaging in the diagnosis of pedal osteomyelitis in diabetic patients.Financial Disclosure: The author of this article has indicated no relevant relationships that could be perceived as a real or apparent conflict of interest. CME Credit: SNMMI is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to sponsor continuing education for physicians. SNMMI designates each JNM continuing education article for a maximum of 2.0 AMA PRA Category 1 Credits. Physicians should claim only credit commensurate with the extent of their participation in the activity. For CE credit, SAM, and other credit types, participants can access this activity through the SNMMI website (http://www.snmmilearningcenter.org) through September 2019.There are numerous imaging tests for diagnosing musculoskeletal infection. Radiographs are routinely performed, because even when not diagnostic, they provide an anatomic overview of the region of interest that could influence subsequent procedure selection and interpretation. MRI is sensitive and provides superb anatomic detail. Bone scintigraphy accurately diagnoses osteomyelitis in bones not affected by underlying conditions. 67 Ga is used primarily for spondylodiskitis. Although in vitro labeled leukocyte imaging is the radionuclide test of choice for complicating osteomyelitis such as diabetic pedal osteomyelitis and prosthetic joint infection, it is not useful for spondylodiskitis. Antigranulocyte antibodies and antibody fragments have limitations and are not widely available. 111 In-biotin is useful for spondylodiskitis. Radiolabeled synthetic fragments of the antimicrobial peptide ubiquicidin are promising infection-specific agents. 18 F-FDG is the radiopharmaceutical of choice for spondylodiskitis. Its role in diabetic pedal osteomyelitis and prosthetic joint infection is not established. Preliminary data suggest 68 Ga may be useful in musculoskeletal infection. 124 I-fialuridine initially showed promise as an infection-specific radiopharmaceutical, but subsequent investigations were disappointing. The development of PET/CT and SPECT/CT imaging systems, which combine anatomic and functional imaging, has revolutionized diagnostic imaging. These hybrid systems are redefining the diagnostic workup of patients with suspected or known infection and inflammation by improving diagnostic accuracy and influencing patient management.

show abstract

The value of FDG-PET in patients with painful total knee arthroplasty

Cited by 33 publications

References 34 publications

FDG-PET for diagnosing prosthetic joint infection: systematic review and metaanalysis

FDG-PET for diagnosing prosthetic joint infection: systematic review and metaanalysis

Radionuclide Imaging of Musculoskeletal Infections

Radionuclide Imaging of Musculoskeletal Infection: A Review

Contact Info

Product

Resources

About