The Value of First-Day Bilirubin Measurement in Predicting the Development of Significant Hyperbilirubinemia in Healthy Term Newborns

Alpay, Faruk; Sarıcı, S. Ümit; Tosuncuk, H D; Serdar, Muhittin; İnanç, Nevsun; Gökçay, Erdal

doi:10.1542/peds.106.2.e16

Cited by 94 publications

(84 citation statements)

References 20 publications

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“…Thus all new borns should be considered for screening irrespec ve of sex and mode of delivery. This was consistent with observa ons of S Umit et al 12,17 and Frauk Aplay et al 4 Birth weight did not have any bearing on the development of signifi cant jaundice. Mean birth wt.…”

Section: Discussionsupporting

confidence: 91%

“…Frauk Aplay et al reported 3310±305gm Vs 3240±34gm in hyperbilirubinaemia and non hyprebilirubinaemia group respec vely. 4 S Umit Sarici et al reported birth weight of 2794±418gm and 2772±157gm in two groups. 17 S Umit et al observed mean birth weight of 3214±828gmgm and 3212± 196 gm in two groups 12 .…”

Section: Discussionmentioning

confidence: 95%

“…To target health care resources towards high risk newborns cord bilirubin, 1 st day bilirubin and pre discharge bilirubin values have been used to predict signifi cant hyperbilirubinaemia in healthy term new born to keep a close follow up and plan interven on if needed 4,6,7,8,9 . These studies did not include ABO or RH incompa bility.…”

Section: Introductionmentioning

confidence: 99%

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Cord Serum Bilirubin Level in Predicting the Development of Significant Hyperbilirubinemia in Newborns with ABO Incompatibility

Arora

Shifali

2016

J. Nepal Paedtr. Soc.

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Introduction: Neonatal hyperbilirubinaemia is common problem which is benign in majority of neonates. Rh iso immune hemolytic disease as a cause of hyperbilirubinemia is becoming nearly nonexistent due to the use of prophylactic anti D. Hence Isoimmune hemolytic disease due to ABO incompatibility assumes significance as a cause of significant hyperbilirubinaemia. This study was conducted to determine the incidence of ABO incompatibility, ABO iso immune disease in new born, to determine critical cord serum bilirubin level to predict subsequent significant hyperbilirubinemia. Material and Methods: The study was done in neonatal ICU of a tertiary care hospital where 100 full term healthy newborns with B.W≥2500gm and gestational age ≥37 wk with blood group A, B, AB, born to mothers with O blood group without simultaneous Rh incompatibility at SGRDIMSR were included. Serum bilirubin was measured approximately at 12-24hrs, 36-48hrs, 60-72hrs. Results: Out 100 ABO incompatible newborns 33(33%) developed ABO isoimmune disease manifesting as significant hyperbilirubinaemia with any of the four total serum bilirubin levels exceeding threshold levels defined for phototherapy. TSB of ≥ 2.16mg/d1 from cord blood has a sensitivity of 100% specificity of 89.55%, NPV 100% and PPV of 82.50% to predict significant hyperbilirubinaemia. Conclusion: A critical cord S.bilirubin between 2.16 mg/d1 and 4.09mg/d1 will predict all newborns who will have significant hyperbilirubinaemia and can be used as a safe demarcator to decide time of discharge. Any therapeutic intervention if necessary can be started as early as possible.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 95%

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Cord Serum Bilirubin Level in Predicting the Development of Significant Hyperbilirubinemia in Newborns with ABO Incompatibility

Arora

Shifali

2016

J. Nepal Paedtr. Soc.

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“…Many investigators have tried to find a simple marker to predict hyperbilirubinemia and its subsequent course in newborns like cord bilirubin estimation 12,13 , bilirubin estimation during 6 to 24 hours of age [14][15][16][17] , predischarge hour specific bilirubin estimation 18 and transcutaneous bilirubin measurement [19][20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

Study of Correlation of Cord Blood Bilirubin with Neonatal Hyperbilirubinemia

Ahire¹,

Sonawane²,

Gaikwad³

et al. 2016

MVP J Med Sci

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Introduction: Neonatal Hyperbilirubinemia (NH) is a universal problem affecting nearly 60% of term and 80% of preterm neonates during first week of life. Early discharge of healthy term newborns is a common practice because of medical, social and economic constraints. Insignificant number (6.5%) of babies, NH is a cause for readmission. The present study was conducted to correlate the Cord Blood Bilirubin (CBB) level with subsequent NH. Methods: Study was performed at the Department of Pediatrics in a Medical College Hospital and Research Centre. Intramurally delivered, 113 Healthy fullterm newborns during 1-year period were prospectively enrolled. CBB was estimated. Serum Bilirubin estimation was done at 48 hours and 5 day of age and later if required. Results: Significant NH in our study is 3.5%. Mean total bilirubin on second postnatal day was 10.58 mg/dl and on fifth post natal day was 10.81 mg/dl. Using CBB level of ≥3 mg/dl as a cut-off, NH can be predicted with sensitivity of 100%, specificity of 98.17 %, positive predictive value of 66.67 % and negative predictive value of 100%. Conclusion: A 100% Negative Predictive Value in the present study suggests that in Healthy Term babies (without RH and ABO incompatibility with Cord Blood Bilirubin ≤3mg/dl) cord serum bilirubin can help to identify those newborns who are unlikely to require further evaluation and intervention. These newborns can be discharged with assurance to Parents. Babies with CBB level ≥3mg/dl should be followed more frequently.

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“…Alpay ve ark. [21] da hemoglobin düzeyi, cins, doğum şekli, doğum tartısı, gestasyonel yaş ve maternal sigara içimi gibi faktörler-le hiperbilirubinemi arasında anlamlı bir ilişki saptamamışlardır.…”

Section: Discussionunclassified

The predictive value of 6-12th hour and 24th hour bilirubin levels in determining significant hyperbilirubinemia among healthy term neonates

Özgürhan¹,

Yiğit²,

Korğalı³

et al. 2013

J Kartal TR

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ÖzetAmaç: Bu çalışmada, term bebeklerde 6-12. saat ve 24. saatteki bilirübin değerlerinin oluşabilecek belirgin hiperbilirü-bineminin göstergesi olup olmadığı değerlendirildi. Gereç ve Yöntem:Çalışmaya sağlıklı, term hiperbilirübine-mi tanısı alan yenidoğanlar alındı. Serum total bilirubin öl-çümleri yaşamın ilk 6-12. saatleri arasında yapıldı. Takip eden günlerde 24, 48, 72 ve 96. saatlerde tekrarlandı. Olguların 6-12. saatler arasındaki ve 24. saatteki bilirubin değerleri ROC analizi ile belirgin hiperbilirubineminin göstergesi olup olmadığı açısından değerlendirildi. Bulgular: Çalışmada 134'ü (%48.5) erkek, 142'si (%51.5) kız 276 yenidoğan değerlendirildi. Klinik sarılık 240 (%86) olguda görüldü. Otuz yedi (%13.4) olguda belirgin hiperbilirubinemi gelişti. 6.-12. saatler arasındaki 3.9 mg/dl'nin üzerin-deki bilirubin değerleri %67.6 duyarlılık, %64.9 özgüllük ile (p<0.002) anlamlı bulundu. Pozitif prediktif değer %22.9, negatif prediktif değer %92.8 idi. 24. saatteki 7.7 mg/dl'nin üze-rindeki bilirubin değerleri %78.4 duyarlılık, %77.8 özgüllük ile (p<0.001) anlamlı bulundu. Pozitif prediktif değer %35.4, negatif prediktif değer %95.9 idi. 24. saatteki bilirubin değerlerinin 6-12. saatler arasındaki bilirubin değerlerine göre belirgin hiperbilirubineminin göstergesi olmak açısından daha anlamlı olduğu tespit edildi.Sonuç: Erken taburcu edilen yenidoğanlarda 24. saatteki bilirubin değerleri ileriki günlerde gelişebilecek belirgin hiperbilirubineminin göstergesi olarak anlamlı bir ölçüttür.Anahtar sözcükler: Hiperbilirubinemi; total bilirübin düzeyi; yenidoğan. Summary Background:The predictive value of 6-12th and 24th hour bilirubin levels in determining significant hyperbilirubinemia among healthy term neonates was evaluated in this study.

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The Value of First-Day Bilirubin Measurement in Predicting the Development of Significant Hyperbilirubinemia in Healthy Term Newborns

Cited by 94 publications

References 20 publications

Cord Serum Bilirubin Level in Predicting the Development of Significant Hyperbilirubinemia in Newborns with ABO Incompatibility

Cord Serum Bilirubin Level in Predicting the Development of Significant Hyperbilirubinemia in Newborns with ABO Incompatibility

Study of Correlation of Cord Blood Bilirubin with Neonatal Hyperbilirubinemia

The predictive value of 6-12th hour and 24th hour bilirubin levels in determining significant hyperbilirubinemia among healthy term neonates

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