The value of fluorine-18 deoxyglucose positron emission tomography scans in patients with ventricular assist device specific infections†

Bernhardt, A.; Pamirsad, M.; Brand, C.; Reichart, Daniel; Tienken, Milena; Barten, Markus J.; Schaefer, Andreas; Grahn, Hanno; Rybczynski, Meike; Deuse, T.; Reichenspurner, Hermann; Wagner, Florian

doi:10.1093/ejcts/ezx016

Cited by 25 publications

(16 citation statements)

References 14 publications

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“…In other studies, observers were either not blinded to clinical context of patients or assessment of non-attenuation-corrected images was not described. Two studies performed the reference test fully in accordance with ISHLT recommendations [27,29]. Two studies had high applicability concerns for both index test and reference test, because they focused on the LVAD driveline only [19,20].…”

Section: Methodological Quality Of Included Studiesmentioning

confidence: 99%

“…In all studies, FDG-PET scans were performed on a hybrid PET/CT system, combining an FDG-PET scan with a lowdose CT for anatomical reference and attenuation correction. In one study, the FDG-PET scan was combined with diagnostic CTA [27]. Reporting of injected activity differed between studies: while some reported an injected activity per kilogram of body weight, others reported a mean total injected activity with lower and upper ranges.…”

Section: Technical Aspectsmentioning

confidence: 99%

“…The ability of FDG-PET/CT to predict outcome and help inform management of device infections was discussed in three of the articles included in the systematic review [24,25,27]. In one [25].…”

Section: Impact On Prognosis and Patient Managementmentioning

confidence: 99%

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The value of 18F-FDG PET/CT for the diagnosis of device-related infections in patients with a left ventricular assist device: a systematic review and meta-analysis

Hove

Treglia

Slart

et al. 2020

Eur J Nucl Med Mol Imaging

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Background Left ventricular assist devices (LVADs) are increasingly used for the treatment of advanced heart failure. LVADs improve quality of life and decrease mortality, but the driveline carries substantial risk for major infections. These device-related LVAD and driveline infections are difficult to diagnose with conventional imaging. We reviewed and analysed the current literature on the additive value of 18 F-fluorodeoxyglucose positron emission tomography combined with computed tomography (FDG-PET/CT) imaging for the diagnosis of LVAD-related infections." Materials/methods We performed a systematic literature review using several databases from their inception until the 31st of December, 2019. Studies investigating the diagnostic performance of FDG-PET/CT in patients with suspected LVAD infection were retrieved. After a bias risk assessment using QUADAS-2, a study-aggregate meta-analysis was performed on a per examination-based analysis. Results A total of 10 studies were included in the systematic review, eight of which were also eligible for study-aggregate metaanalysis. For the meta-analysis, a total of 256 FDG-PET/CT scans, examining pump/pocket and/or driveline infection, were This article is part of the Topical Collection on Infection and inflammation B. Sinha and A. W. J. M. Glaudemans are shared authorship Electronic supplementary material The online version of this article (

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Section: Methodological Quality Of Included Studiesmentioning

confidence: 99%

Section: Technical Aspectsmentioning

confidence: 99%

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The value of 18F-FDG PET/CT for the diagnosis of device-related infections in patients with a left ventricular assist device: a systematic review and meta-analysis

Hove

Treglia

Slart

et al. 2020

Eur J Nucl Med Mol Imaging

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“…Bernhardt et al [29] reported the sensitivity of FDG PET/CT in LVAD infections as 87.5%, the specificity as 100%, the PPV as 100%, and the NPV as 86.7%. They also confirmed the utility of FDG PET/CT in the location and quantification of the extent of infection.…”

Section: Left Ventricular Assist Device Infectionmentioning

confidence: 99%

F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the infection of heart

Kong

2021

Yeungnam Univ J Med

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Infections involving the heart are becoming increasingly common, and a timely diagnosis of utmost importance, despite its challenges. F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) is a recently introduced diagnostic tool in cardiology. This review focuses on the current evidence for the use of FDG PET/CT in the diagnosis of infective endocarditis, cardiac implantable device infection, left ventricular assist device infection, and secondary complications. The author discuss considerations when using FDG PET/CT in routine clinical practice, patient preparation for reducing physiologic myocardial uptake, acquisition of images, and interpretation of PET/CT findings. This review also functions to highlight the need for a standardized acquisition protocol.

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“…3,[16][17][18] In this issue, de Vaugelade et al 19 retrospectively analyzed the diagnostic performance of both radiolabeled leucocyte scintigraphy and 18F-FDG PET/CT in 24 LVAD-recipients with suspected devicerelated infection. Their conclusion is that 18F-FDG PET/CT demonstrated a higher sensitivity compared to radiolabeled leucocyte scintigraphy and could be preferred as first-line radionuclide imaging procedure.…”

mentioning

confidence: 99%

Diagnosis of infection in patients with left ventricular assist device: PET or SPECT?

Legallois

Manrique

2019

Journal of Nuclear Cardiology

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The value of fluorine-18 deoxyglucose positron emission tomography scans in patients with ventricular assist device specific infections†

Abstract: PET-CT scan findings showed a high specificity and positive predictive value for VAD-specific infections. Therefore, it may have the potential to guide the clinician in handling patients with infectious complications after VAD implantation.

Cited by 25 publications

References 14 publications

The value of 18F-FDG PET/CT for the diagnosis of device-related infections in patients with a left ventricular assist device: a systematic review and meta-analysis

The value of 18F-FDG PET/CT for the diagnosis of device-related infections in patients with a left ventricular assist device: a systematic review and meta-analysis

F-18 fluorodeoxyglucose positron emission tomography/computed tomography in the infection of heart

Diagnosis of infection in patients with left ventricular assist device: PET or SPECT?

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