The Value of GeneXpert MTB/RIF for Detection in Tuberculosis: A Bibliometrics-Based Analysis and Review

Li, Zhiyi

doi:10.1155/2022/2915018

Cited by 7 publications

(4 citation statements)

References 86 publications

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“…Another study using the Verigene ® Gram-Negative Blood Culture Nucleic Acid Test (Nanosphere Inc., Northbrook, IL, USA) reported an overall concordance between the rapid test and culture results of 96.3%, with an accuracy of 100% for Acinetobacter baumanii strains and 86.1% for Klebsiella pneumoniae [32]. The GeneXpert ® system (Cepheid TM , Sunnyvale, CA, USA) we used in our study has the background of being among the first assays used for quick MDR detection in tuberculosis, and there is extensive evidence attesting its diagnostic capabilities in that field [33][34][35]. Regarding its use in the ICU setting, there are three available kits for the identification of the most relevant drug-resistant mutations, namely the Carba-R, the MRSA/SA SSTI, and the vanA/vanB assay, all used in our pilot study.…”

Section: Discussionmentioning

confidence: 85%

Rapid Point-of-Care PCR Testing of Drug-Resistant Strains on Endotracheal Aspirate Samples: A Repurposed Effective Tool in the Stepwise Approach of Healthcare-Acquired Pneumonia—A Pilot Study

Bălan,

Bodolea,

Nemes

et al. 2023

IJMS

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Healthcare-associated pneumonia (HCAP) is a common nosocomial infection with high morbidity and mortality. Culture-based detection of the etiologic agent and drug susceptibility is time-consuming, potentially leading to the inadequate use of broad-spectrum empirical antibiotic regimens. The aim was to evaluate the diagnostic capabilities of rapid point-of-care multiplex polymerase chain reaction (PCR) assays from the endotracheal aspirate of critically ill patients with HCAP. A consecutive series of 29 intensive care unit (ICU) patients with HCAP and a control group of 28 patients undergoing elective surgical procedures were enrolled in the study. The results of the PCR assays were compared to the culture-based gold standard. The overall accuracy of the PCR assays was 95.12%, with a sensitivity of 92.31% and a specificity of 97.67%. The median time was 90 min for the rapid PCR tests (p < 0.001), while for the first preliminary results of the cultures, it was 48 h (46–72). The overall accuracy for rapid PCR testing in suggesting an adequate antibiotic adjustment was 82.98% (95% CI 69.19–92.35%), with a specificity of 90% (95% CI 55.50–99.75%), a positive predictive value of 96.77% (95% CI 83.30–99.92%), and a negative predictive value of 56.25 (95% CII 29.88–80.25%). This method of rapid point-of-care PCR could effectively guide antimicrobial stewardship in patients with healthcare-acquired pneumonia.

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Section: Discussionmentioning

confidence: 85%

Rapid Point-of-Care PCR Testing of Drug-Resistant Strains on Endotracheal Aspirate Samples: A Repurposed Effective Tool in the Stepwise Approach of Healthcare-Acquired Pneumonia—A Pilot Study

Bălan,

Bodolea,

Nemes

et al. 2023

IJMS

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“…As a discipline that reveals the development patterns and trends of scientific research, bibliometrics plays a crucial role in the study of LC and PTB [50, 51]. However, a comprehensive bibliometric analysis of the LC‐PTB domain has not been conducted to date.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the study of LC-PTB co-morbidity is important for early warning, precise diagnosis, and individualized treatment. As a discipline that reveals the development patterns and trends of scientific research, bibliometrics plays a crucial role in the study of LC and PTB [50,51]. However, a comprehensive bibliometric analysis of the LC-PTB domain has not been conducted to date.…”

Section: Analysis Of Research Trends and Frontiersmentioning

confidence: 99%

Visualization analysis of research progress and trends in coexistence of lung cancer and pulmonary tuberculosis using bibliometrics

Yang,

Ye,

et al. 2024

Medicine Advances

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BackgroundThe incidence of lung cancer combined with pulmonary tuberculosis has been increasing, but there is relatively limited published literature on the topic of lung cancer combined with tuberculosis (LC‐PTB) from a bibliometric perspective. Therefore, in this study, we aimed to quantitatively analyze the LC‐PTB‐related literature to better understand the current status of this field and identify future research trends.MethodsWe searched for articles related to LC‐PTB using the Web of Science Core Collection (SCI‐E) and conducted a visual analysis of publication quantity, countries, institutions, authors, journals, references, and keywords using bibliometric software (CiteSpace, VOSviewer, and Scimago Graphica).ResultsAs of January 8, 2024, a total of 460 publications related to LC‐PTB were included for analysis from 3705 retrieved records. The number of publications has been increasing almost yearly, with most from China (n = 123), followed by the United States (n = 77). Taipei Medical University contributed the most publications (n = 11). Jing‐Yang Huang and Yung‐Po Liaw (eight documents each) ranked first among the included authors. The Journal of Thoracic Oncology was the most productive academic journal on LC‐PTB. The aggregation of key nodes in the co‐citation network and the chronological sequence indicated that LC‐PTB research has shifted from initial hotspots such as lung diseases, bronchitis, and exposure to recent areas, including immunotherapy, immune checkpoint inhibitors, and nivolumab.ConclusionIn this study, we visualized the current status of LC‐PTB research as well as future trends using bibliometric methods, providing new insights into the differential diagnosis of LC‐PTB and its related promoting mechanisms.

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“…Due to its timeliness, high sensitivity, and high specificity compared to acid-fast bacilli (AFB) smears and cultures, the Xpert has gained widespread use, particularly in diagnosing multi-drug resistant (MDR) TB, as well as TB in people living with HIV (PLWH). Numerous studies have been performed evaluating Xpert's utility 4,5 , prompting policy recommendations from the World Health Organization (WHO) 6 . While Xpert offers rapid diagnosis, its high laboratory cost, encompassing consumables, annual calibrations, and maintenance, restricts its use in resource-limited settings where access to NAAT technologies might be inconsistent.…”

mentioning

confidence: 99%

Diagnostic Accuracy of Nanopore Sequencing for DetectingMycobacterium tuberculosisand Drug-Resistant Strains: A Systematic Review and Meta-Analysis

Carandang,

Cunanan,

et al. 2024

Preprint

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Tuberculosis (TB), caused byMycobacterium tuberculosis(MTB) infection, remains a significant public health threat. The timeliness, portability, and capacity of nanopore sequencing for diagnostics can aid in early detection and drug susceptibility testing (DST), which is crucial for effective TB control. This study synthesized current evidence on the diagnostic accuracy of the nanopore sequencing technology in detecting MTB and its DST profile. A comprehensive literature search in PubMed, Scopus, MEDLINE, Cochrane, EMBASE, Web of Science, AIM, IMEMR, IMSEAR, LILACS, WPRO, HERDIN Plus, MedRxiv, and BioRxiv was performed. Quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Pooled sensitivity, specificity, predictive values (PV), diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated. Thirty-two studies were included; 13 addressed MTB detection only, 15 focused on DST only, and 4 examined both MTB detection and DST. No study used Flongle or PromethION. Seven studies were eligible for meta-analysis on MTB detection and five for DST; studies for MTB detection used GridION only while those for DST profile used MinION only. Our results indicate that GridION device has high sensitivity [88.61%; 95% CI (83.81–92.12%)] and specificity [93.18%; 95% CI (85.32–96.98%)], high positive predictive value [94.71%; 95% CI (89.99–97.27%)], moderately high negative predictive value [84.33%; 95% CI (72.02–91.84%)], and excellent DOR [107.23; 95% CI (35.15–327.15)] and AUC (0.932) in detecting MTB. Based on DOR and AUC, the MinION excelled in detecting pyrazinamide and rifampicin resistance; however, it underperformed in detecting isoniazid and ethambutol resistance. Additional studies will be needed to provide more precise estimates for MinION’s sensitivity in detecting drug-resistance, as well as DOR in detecting resistance to pyrazinamide, streptomycin, and ofloxacin. Studies on detecting resistance to bedaquiline, pretomanid, and linezolid are lacking.

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The Value of GeneXpert MTB/RIF for Detection in Tuberculosis: A Bibliometrics-Based Analysis and Review

Cited by 7 publications

References 86 publications

Rapid Point-of-Care PCR Testing of Drug-Resistant Strains on Endotracheal Aspirate Samples: A Repurposed Effective Tool in the Stepwise Approach of Healthcare-Acquired Pneumonia—A Pilot Study

Rapid Point-of-Care PCR Testing of Drug-Resistant Strains on Endotracheal Aspirate Samples: A Repurposed Effective Tool in the Stepwise Approach of Healthcare-Acquired Pneumonia—A Pilot Study

Visualization analysis of research progress and trends in coexistence of lung cancer and pulmonary tuberculosis using bibliometrics

Diagnostic Accuracy of Nanopore Sequencing for DetectingMycobacterium tuberculosisand Drug-Resistant Strains: A Systematic Review and Meta-Analysis

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