In order to evaluate the relationship between the patient-identified regions of abdominal pain and the disease diagnosis, a prospective study was conducted at General Medicine Outpatient Clinic, Saga Medical School Hospital.Four hundred eighty-nine outpatients complaining of abdominal pain at the first visit were classified into 10 groups according to the pain region complained of, i.e., whole abdominal, epigastric, right subcostal, left subcostal, right flank, left flank, periumbilical, right-lower, mid-lower, and left-lower; the clinic physicians and authors in joint-participation assigned the groups through studying the medical records. Comparisons were made in order to calculate sensitivity, specificity, and the positive and negative likelihood ratios between the pain regions and disease diagnoses.In general, the sensitivity of history-taking and physical examination is low, but specificity is high in relation to epigastric pain and gastroduodenal diseases, right subcostal pain and hepatobiliary diseases, and mid lower pain and gynecological diseases (above 0.5).Comparative analysis between the pain regions complained of by the patient in the initial clinic visit and the medical diagnoses yielded clinically useful information as to the efficacy of medical history-taking and physical examination in the identification of abdominal diseases. J Epidemiol, 1997 ; 7 : 27-32. abdominal pain, diagnosis, sensitivity, specificityUnlike imaging techniques such as ultrasonography, radionuclide scanning, and computed tomography, the value of history taking and physical examination, which are not infrequently most important part of diagnostic process, has been rarely evaluated by scientific methods. Recently, however, some researchers have made use of epidemiological methods in evaluating these basic clinical skills in clinical practice '-4) Regarding abdominal pain, textbooks describe that pain in certain abdominal regions ensue in a given certain disease state. However, there are few reports that indicate precisely how we can determine the diseased organ by identifying the pain region. Eskelien et al 5). reported that the most significant predictors of acute appendicitis in patients older than 50 years of age were tenderness (relative risk (RR) = 39.4), rigidity (RR = 18.8), and pain at diagnosis (RR = 11.0). The sensitivity of the preoperative clinical decision in detecting acute appendicitis in the elderly patients was 0.87, with a specificity of 0.92. found that the most efficient symptoms in diagnosis of acute small-bowel obstruction were previous abdominal surgery (RR=12.1) and type of pain (colic/intermittent versus steady) (RR=2.4). On the other hand, Malone et al 8). reported that the unenhanced computed tomography (CT) had a sensitivity of 0.87 and a specificity of 0.97 for the initial examination of patients with suspected acute appendicitis. That is the accuracy of unenhanced CT was mostly the same as that of rigidity of pain in the right-lower quadrant in detecting acute appendicitis. Davies et al 9). ...