The value of immunophenotyping hepatocellular adenomas: consecutive resections at one UK centre

Bellamy, Christopher; Maxwell, R Scott; Prost, Sandrine; Azodo, Ijeoma A; Powell, James J.; Manning, Jonathan

doi:10.1111/his.12011

Cited by 38 publications

(16 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, occasional hepatic adenomas and focal nodular hyperplasias can have a diffuse pattern that is essentially indistinguishable from hepatocellular carcinoma [ 29 -32 ]. For example, one study found diffuse sinusoidal CD34 staining in 27 % of hepatocellular adenomas, which correlated with beta catenin activated or unclassifi ed type of adenomas [ 32 ]. For all of these reasons, CD34 is used less often than some of the other available stains and is never used alone, but can still be useful.…”

Section: Cd34 Stainmentioning

confidence: 99%

Hepatocellular Carcinoma

Torbenson¹

2015

Surgical Pathology of Liver Tumors

View full text Add to dashboard Cite

Hepatocellular carcinoma is the most common primary malignant tumor of the liver. Although usually morphologically distinct, hepatocellular carcinomas can demonstrate various histologic patterns, which sometimes create diagnostic challenges for the surgical pathologist. In addition, a number of subtypes are discussed in this chapter, along with typical hepatocellular carcinoma. This chapter examines the clinical, gross, and microscopic features of hepatocellular carcinoma and its variants with illustrated examples. The differential diagnosis of hepatocellular carcinoma is also covered, with a detailed discussion of the various special stains used in the diagnosis of hepatocellular carcinoma and their respective utilities and limitations. Important prognostic factors, including grading of hepatocellular carcinoma, are also reviewed.

show abstract

Section: Cd34 Stainmentioning

confidence: 99%

Hepatocellular Carcinoma

Torbenson¹

2015

Surgical Pathology of Liver Tumors

View full text Add to dashboard Cite

show abstract

“…These histologic and immune-phenotypic features upon which the diagnosis of HCC was made have been wellestablished. [25][26][27] The diagnosis of HCC in this H-HCA was independently rendered by three liver pathologists from three different institutions. Although H-HCA has been considered to be without malignant potential, the relative rarity of HCAs, as well as their relatively early detection, may account for this impression.…”

Section: Discussionmentioning

confidence: 99%

Hepatocellular Carcinoma Arising in an HNF-1α–Mutated Adenoma in a 23-Year-Old Woman with Maturity-Onset Diabetes of the Young: A Case Report

Stueck

Huang

et al. 2015

Semin Liver Dis

View full text Add to dashboard Cite

Hepatocyte nuclear factor-1α mutated hepatocellular adenomas (H-HCA) are thought to have no to minimal malignant potential. This report describes a 23-year-old woman with maturity-onset diabetes of the young who developed a 12.5-cm hepatic mass with a radiographically and pathologically distinct 3.0-cm region. Histologically and immunohistochemically, the bulk of the mass was an H-HCA with extensive pseudoglandular formation and only focal steatosis. The 3.0-cm nodule showed small cell change, thickened hepatocyte plates, pleomorphic and hyperchromatic nuclei, reticulin loss, and stromal and vascular invasion, diagnostic of hepatocellular carcinoma (HCC). Immunohistochemically, increased expression of glutamine synthetase in tumor cells and CD34 expression in sinusoidal endothelial cells were seen in the HCC component. Nuclear expression of β-catenin, and exon 3 of CTNNB1 and TERT promoter mutations were absent in this case. Thus, we report a HCC arising in an H-HCA; although cases appear exceedingly rare, they reinforce the potential of H-HCA for malignant transformation.

show abstract

“…Similar findings of inconsistent GS staining results are discussed in a review of HCA cases from Scotland. 27 In addition to these difficulties with immunohistochemistry, β-HCA can be difficult or impossible to be distinguished from well differentiated HCC because of the cytological atypia and acinar growth pattern. 8 …”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases

et al. 2013

View full text Add to dashboard Cite

BackgroundHepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1α [HNF1α]-mutated, β-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group.MethodsWe used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports.ResultsSeven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for β-catenin-mutated HCA. HNF1α-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1α or β-catenin genes and no inflammatory protein expression is categorized as unclassified HCA.ConclusionsAlthough the new classification is now generally accepted, validation through follow-up studies is necessary.

show abstract

The value of immunophenotyping hepatocellular adenomas: consecutive resections at one UK centre

Abstract: The distribution of adenoma types in this population matches that in others, and immunoprofiling is required for accurate typing. Carcinoma ex-adenoma is uncommon and fits the published risk profile (large size and GS-positive).

Cited by 38 publications

References 34 publications

Hepatocellular Carcinoma

Hepatocellular Carcinoma

Hepatocellular Carcinoma Arising in an HNF-1α–Mutated Adenoma in a 23-Year-Old Woman with Maturity-Onset Diabetes of the Young: A Case Report

Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases

Contact Info

Product

Resources

About