The value of inflammatory biomarkers in the occurrence and prognosis of sudden sensorineural hearing loss: a meta-analysis

Chen, Li; Wang, Maohua; Zhang, Wentao; Zhang, Xu; Jiao, Cheng; Yu, Youjun; Guan, Bing; Zhong, Zhenhua

doi:10.1007/s00405-022-07806-9

Cited by 9 publications

(3 citation statements)

References 50 publications

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“… 6 7 8 22 Several studies have found high NLR and PLR values to be associated with a worse prognosis in neuro-otological diseases including Bell’s palsy and sudden sensorineural hearing loss. 23 24 25 Although NLR has been considered an inflammatory biomarker in peripheral vertigo, the usefulness of this parameter as a prognostic predictor remains inconclusive in AUV. 9 10 11 12 13 14 15 16 One study found a significant relationship between NLR and the clinical severity of AUV, but those authors evaluated the disease severity using the duration of subjective dizziness requiring antivertigo drugs, rather than using an objective questionnaire.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Acute Unilateral Vestibulopathy

Oh,

Kim,

Choi

et al. 2024

J Clin Neurol

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Background and Purpose The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been identified as useful biomarkers for assessing the inflammatory response and for predicting the prognosis of various diseases. This study aimed to determine the clinical significance and effects on prognostic prediction of NLR and PLR in acute unilateral vestibulopathy (AUV). Methods We retrospectively recruited 128 patients who were diagnosed with AUV from July 2016 to April 2021, and compared NLR and PLR values between these patients with AUV and age- and sex-matched healthy subjects. We also analyzed the correlations of various clinical parameters with NLR and PLR. Results NLR and PLR in the AUV group were 3.41±2.80 (mean±standard deviation) and 128.86±67.06, respectively, with only NLR being significantly higher than that in the control group (1.55±0.60, p <0.001). The gain asymmetry of the horizontal vestibulo-ocular reflex (VOR) was slightly larger in patients with high NLR ( n =52) than in those with normal NLR ( n =76) (41.9%±20.2% vs. 33.6%±17.4%, p =0.048). However, the hospitalization period, preceding infection, canal paresis, and absolute horizontal VOR gain did not differ between patients with high and normal NLR and PLR values. The correlation analyses also revealed that none of the clinical parameters were significantly correlated with NLR or PLR. At 3-month follow-up examinations, NLR and PLR did not differ significantly between patients with and without function recovery of the horizontal VOR. Conclusions This study found a high NLR in AUV, suggesting an acute inflammatory status in the vestibular organ. However, the usefulness of NLR and PLR as prognostic markers remains unclear.

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Section: Discussionmentioning

confidence: 99%

Clinical Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Acute Unilateral Vestibulopathy

Oh,

Kim,

Choi

et al. 2024

J Clin Neurol

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“…We believe that this could be an interesting field of research and development [ 2 ]. Recent studies have described the search for valuable biomarkers in SSHL diagnosis and prognosis, such as HSP70, Prestin, IL-10, serum α-1-acid glycoprotein, galectin-3, and the C-reactive protein to serum albumin ratio [ 40 , 41 , 42 ], and an association with NfL could be investigated.…”

Section: Discussionmentioning

confidence: 99%

Neurofilament Expression as a Biomarker of Post-COVID-19 Sudden Sensorineural Hearing Loss

et al. 2023

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Sudden sensorineural hearing loss (SSHL) affects a patient’s quality of life and requires rapid treatment. The etiology is viral, vascular, and autoimmune, even though, in most cases, it remains idiopathic SSHL. Since 2019, several different complications have been identified following COVID-19 infection. The post-COVID-19 ENT manifestations reported in the literature are sore throat, headache, pharyngeal erythema, nasal obstruction, rhinorrhea, upper respiratory tract infection, and tonsil enlargement. Cases of SSHL, vestibular neuronitis, and audio-vestibular disorders (such as tinnitus, dizziness, and vertigo) have also been reported, albeit in a smaller percentage of patients. We reported our experience of a case of post-COVID-19 SSHL in the absence of any other type of post-COVID symptoms or brain and internal auditory canal magnetic resonance imaging and magnetic resonance angiography modifications. We aimed to identify a serological biomarker of sudden sensorineural hearing loss, and we also dosed and monitored the value of the serum neurofilament light (NfL). the best of our knowledge, this is the first report that associates SSHL and the serological increase in NfL as a potential biomarker of neuronal-disease-related damage.

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“…Likewise, the platelet-to-lymphocyte ratio (PLR) was identified as an indicator of unfavorable prognosis in peripheral arterial diseases like atherosclerosis [22]. In a recent meta-analysis by Chen et al [23] including 1423 SSNHL patients and 1429 healthy controls, it was demonstrated that NLR and PLR were increased in SSNHL patients compared to the control group and were linked to poor recovery.…”

Section: The Role Of Inflammatory Biomarkersmentioning

confidence: 99%

Endothelial Dysfunction and Metabolic Disorders in Patients with Sudden Sensorineural Hearing Loss

Cavallaro,

Pantaleo,

Pontillo

et al. 2023

Medicina

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Sudden sensorineural hearing loss (SSNHL) is defined as a sensorineural hearing loss of 30 dB or greater on at least three contiguous audiometric frequencies occurring within a 72 h period. Although SSNHL is commonly encountered in clinical audiology and otolaryngology practice, its etiopathogenesis continues to be poorly understood. Scientific investigations have highlighted the vulnerability of cochlear microcirculation to blood flow alterations. Even mild hypoperfusion can lead to immediate dysfunction in the organ of Corti, given the heightened susceptibility of cochlear hair cells to hypoxia and ischemic damage. The purpose of this review paper is to present evidence of endothelial and vascular involvement in SSNHL and the risk factors, such as metabolic syndrome, that may negatively impact the inner ear’s vascular supply, influencing the onset pattern, incidence, and prognosis of SSNHL. By addressing these variables, we can deepen our comprehension of the mechanisms underlying SSNHL and potentially uncover strategies for prevention.

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The value of inflammatory biomarkers in the occurrence and prognosis of sudden sensorineural hearing loss: a meta-analysis

Cited by 9 publications

References 50 publications

Clinical Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Acute Unilateral Vestibulopathy

Clinical Significance of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Acute Unilateral Vestibulopathy

Neurofilament Expression as a Biomarker of Post-COVID-19 Sudden Sensorineural Hearing Loss

Endothelial Dysfunction and Metabolic Disorders in Patients with Sudden Sensorineural Hearing Loss

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