The Value of Intraoperative and Early Postoperative Magnetic Resonance Imaging in Low-Grade Glioma Surgery: A Retrospective Study

Paľa, Andrej; Brand, Christine; Kapapa, Thomas; Hlaváč, Michal; König, Ralph; Schmitz, Bernd; Wirtz, Christian Rainer; Coburger, Jan

doi:10.1016/j.wneu.2016.04.120

Cited by 20 publications

(11 citation statements)

References 13 publications

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“…Volumetric data was obtained using iPlan software (version 3.0.0, BrainLAB, Feldkirchen, Germany) by manually demarcating tumor involvement in each imaging slice. This technique has been utilized and validated in a wide variety of studies . Of 24 patients with neck involvement in our cohort, 11 could not be evaluated due to an inability to access preoperative scans from outside institutions in our BrainLAB software.…”

Section: Methodsmentioning

confidence: 99%

“…This technique has been utilized and validated in a wide variety of studies. [14][15][16][17] Of 24 patients with neck involvement in our cohort, 11 could not be evaluated due to an inability to access preoperative scans from outside institutions in our BrainLAB software. The remaining 13 cases with neck involvement were examined by two separate observers who were blinded to each other's results.…”

Section: Volumetric Analysis Of Tumorsmentioning

confidence: 99%

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Volumetric analysis of olfactory neuroblastoma skull base laterality and implications on neck disease

et al. 2017

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Section: Methodsmentioning

confidence: 99%

Section: Volumetric Analysis Of Tumorsmentioning

confidence: 99%

Volumetric analysis of olfactory neuroblastoma skull base laterality and implications on neck disease

et al. 2017

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“…Characteristics of Vac-induced glioma cell death include cell blebbing followed by rupture of the plasma membrane. In situ , GBMs contain large areas of necrotic tissue [9, 10], which are likely to be ATP-rich [11]. Extracellular ATP is an important signaling molecule that acts via purinergic receptors and ion channels [12, 13].…”

Section: Introductionmentioning

confidence: 99%

Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP

et al. 2017

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Glioblastomas (GBM) are the most malignant brain tumors in humans and have a very poor prognosis. New therapeutic options are urgently needed. A novel drug, Vacquinol-1 (Vac), a quinolone derivative, displays promising properties by inducing rapid cell death in GBM but not in non-transformed tissues. Features of this type of cell death are compatible with a process termed methuosis. Here we tested Vac on a highly malignant glioma cell line observed by long-term video microscopy. Human dental-pulp stem cells (DPSCs) served as controls. A major finding was that an exogenous ATP concentration of as little as 1 μM counter regulated the Vac-induced cell death. Studies using carvacrol, an inhibitor of transient receptor potential cation channel, subfamily M, member 7 (TRPM7), demonstrated that the ATP-inducible inhibitory effect is likely to be via TRPM7. Exogenous ATP is of relevance in GBM with large necrotic areas. Our results support the use of GBM cultures with different grades of malignancy to address their sensitivity to methuosis. The video-microscopy approach presented here allows decoding of signaling pathways as well as mechanisms of chemotherapeutic resistance by long-term observation. Before implementing Vac as a novel therapeutic drug in GBM, cells from each individual patient need to be assessed for their ATP sensitivity. In summary, the current investigation supports the concept of methuosis, described as non-apoptotic cell death and a promising approach for GBM treatment. Tissue-resident ATP/necrosis may interfere with this cell-death pathway but can be overcome by a natural compound, carvacrol that even penetrates the blood-brain barrier.

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“…[9][10][11]28 Further, intraoperative imaging such as iMRI may improve EoR resulting in an increased PFS. 29 For surgical decision making, it is crucial to generate better evidence on when to operate and which EoR in only partially removable lesions will be most beneficial for the patient's outcome. The main focus of the LoG-Glio registry is to contribute reliable prospective data on patient outcomes after surgical treatment and also on those individuals only observed as outpatients.…”

Section: Challenges In Therapeutic Management Of Low-grade Gliomamentioning

confidence: 99%

Multicentric Registry Study on Epidemiological and Biological Disease Profile as Well as Clinical Outcome in Patients with Low-Grade Gliomas: The LoG-Glio Project

Paľa

Nadji-Ohl

Faust

et al. 2019

J Neurol Surg A Cent Eur Neurosurg

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Background World Health Organization (WHO) grade II low-grade gliomas (LGGs) in adults are rare, and patients' mean overall survival (OS) is relatively long. Epidemiological data on factors influencing tumor genesis and progression are scarce, and prospective data on surgical management are still lacking. Because of the molecular heterogeneity of LGG, a comprehensive molecular characterization is required for any clinical and epidemiological research. Further, a detailed radiologic assessment is needed as the only established objective criterion for progressive disease. Both radiologic and molecular assessments have to be standardized to produce comparable data. The aim of the registry is to improve the evidence for surgical management of LGG patients by establishing a multicenter registry with a strong surgical and clinical focus including mandatory biobanking. Methods The LoG-Glio project is a prospective national observational multicenter registry that began on November 1, 2015. Inclusion criteria encompass all patients > 18 years of age with a radiologic suspicion of LGG. Patients with severe neurologic or psychiatric disorders that may interfere with their informed consent or if there is no possibility for further follow-up are excluded. Diagnosis of glioblastoma WHO grade IV isocitrate dehydrogenase (IDH) wild type leads to a secondary exclusion of patients. In addition to demographic data, results of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, add-on for patients with brain tumors, and National Health Institute Stroke Scale before and after surgery and during regular follow-ups are collected. At each time point a detailed recording of surgical and adjuvant treatment is performed. Radiologic assessment involves three-dimensional (3D) acquisition of T1, fluid-attenuated inversion recovery, and T2 sequences. For the final evaluation, a central detailed neuropathologic and molecular assessment of tumor samples and a radiologic evaluation of imaging sets are part of the study protocol. Results We report the first 100 consecutively registered patients for LoG-Glio. Three patients dropped out due to loss of follow-up. Of the remaining recruited patients, 8 were classified as wait and scan; 89 had surgery. Using the inclusion criteria described previously, 70 patients had an IDH-mutated glioma, 10 had miscellaneous rare LGGs, and 8 patients had an IDH wild-type WHO grade II or III glioma. Conclusion The LoG-Glio registry has been successfully implemented. Applied selection criteria result in an appropriately balanced patient cohort. Short-term outcome data on epidemiology as well as the influence of current surgical techniques and adjuvant treatment on patient outcomes are expected. In the long run, the aim of the registry is to validate the new molecular-based WHO classification and the influence of the extent of resection on progression-free survival and OS. The registry provides an open platform for future research projects benefiting patients with LGG.

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The Value of Intraoperative and Early Postoperative Magnetic Resonance Imaging in Low-Grade Glioma Surgery: A Retrospective Study

Cited by 20 publications

References 13 publications

Volumetric analysis of olfactory neuroblastoma skull base laterality and implications on neck disease

Volumetric analysis of olfactory neuroblastoma skull base laterality and implications on neck disease

Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP

Multicentric Registry Study on Epidemiological and Biological Disease Profile as Well as Clinical Outcome in Patients with Low-Grade Gliomas: The LoG-Glio Project

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