OBJECTIVE: Assess whether inclusion of intrapartum risk factors improves our obstetric hemorrhage risk stratification tool in predicting obstetric hemorrhage, transfusion, and related severe morbidity.
STUDY DESIGN: This is a retrospective cohort study using all live deliveries at a single institution over a two-year period (n = 5,332). Obstetric hemorrhage risk factors, hemorrhage burden, and severe maternal morbidity index outcomes were assessed through chart abstraction. Hemorrhage risk was assessed at: 1. “Time of Admission” through chart abstraction and 2. “Pre-delivery” by calculation after inclusion of all abstracted intrapartum risk factors. Admission high-risk was compared to pre-delivery high-risk for sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, and negative likelihood ratio in predicting obstetric hemorrhage, obstetric hemorrhage requiring transfusion, and obstetric hemorrhage related severe morbidity. Significance levels were calculated using descriptive statistical methods including chi-squared tests and McNemar tests.
RESULTS: The sensitivities of the risk assessment tool using admission risk classification for high-risk patients is: 25% for obstetric hemorrhage, 37% for obstetric hemorrhage requiring transfusion, and 22% for obstetric hemorrhage related severe morbidity. After intrapartum factor inclusion, the sensitivities increase to: 55% for obstetric hemorrhage, 59% for obstetric hemorrhage requiring transfusion, and 47% for obstetric hemorrhage related severe morbidity. This “pre-delivery” risk assessment is significantly more sensitive across all three end points (p < 0.001 for all three outcomes). While the positive likelihood ratios for obstetric hemorrhage are equal on admission and pre-delivery (2.10 on admission and pre-delivery), they increase after intrapartum factor inclusion for obstetric hemorrhage requiring transfusion and obstetric hemorrhage related severe morbidity (on admission, 2.74 and 1.6, respectively, and pre-delivery: 4.57 and 3.58, respectively).
CONCLUSION: Inclusion of intrapartum risk factors increases the accuracy of this obstetric hemorrhage risk stratification tool in predicting patients requiring hemorrhage management with transfusion and obstetric hemorrhage related severe morbidity.