The value of lactate clearance in admission decisions of patients with acute exacerbation of COPD

Durmus, Ugur; Doğan, Nurettın Özgür; Pekdemir, Murat; Yılmaz, Serkan; Yaka, Elif; Karadaş, Adnan; Pinar, S

doi:10.1016/j.ajem.2017.11.002

Cited by 7 publications

(5 citation statements)

References 16 publications

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“…In a study on patients admitted to the ED due to COPD exacerbation, hospitalized and discharged patients were compared and no difference was found between the patients in terms of initial blood lactate levels. In the same study, a significant difference was found between patients with COPD hospitalized or discharged in terms of lactate clearance [12]. The relationship between the LOS and blood lactate levels has been examined in many critical situations in the literature.…”

Section: Discussionmentioning

confidence: 88%

Relationship between lactate level and length of hospital stay in patients with a COPD exacerbation

Sağmen

Naziroğlu

2020

J Clin Med Kaz

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Objective: To investigate the effect of lactate levels on length of hospital stay in patients with chronic obstructive pulmonary disease exacerbation.Material and methods: Patients who were hospitalized for chronic obstructive pulmonary disease exacerbation between October 2017 and December 2018 were evaluated. Those who had pneumonia or any other additional disease that might affect the lactate level during hospitalization were excluded from the study. The arterial blood gas parameters and lactate levels measured at the time of hospitalization were examined. The patients were divided into two groups according to the length of stay: longer than seven days and shorter than seven days. The relationship of lactate levels with the length of hospital stay and requiring non-invasive mechanical ventilation during hospitalization was investigated.Results: A total of 101 patients, 28 females (27.72%) and 73 males (72.28%), participated in the study. The mean age of the patients was 68±9 years. Fifty-seven (56.44%) patients were hospitalized for 7 days or less and 44 patients (43.56%) were hospitalized for more than 7 days. The mean length of hospital stay was 7.37 ± 2.24 days. An examination of the relationship between lactate and length of hospital stay revealed a significant correlation (p<0.001; r=0.791). When the patients were divided into two groups according to their length of hospital stay, lactate levels were found to be higher in patients who were hospitalized for longer than seven days (2.74±0.74) compared with patients who were hospitalized for seven days or less (1.50±0.58) (p<0.001). The body mass index of patients hospitalized for longer than seven days was found to be lower than in the patients hospitalized for seven days or less (p<0.001). The lactate levels of the patients requiring non-invasive mechanical ventilation were found to be higher (2.29±0.91) than the other patients (1.70±0.76) (p=0.001). A determinative cut-off point was examined for the lactate level in hospitalizations of patients. When the lactate value was taken as 1.95, 90.91% sensitivity and 84.21% specificity were obtained.Conclusion: Lactate levels may become important in clinical practice to predict the duration of hospitalization because it can be measured quickly and easily.

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Section: Discussionmentioning

confidence: 88%

Relationship between lactate level and length of hospital stay in patients with a COPD exacerbation

Sağmen

Naziroğlu

2020

J Clin Med Kaz

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“…Generally, hypoperfusion-induced hyperlactacidemia is the major reason for increased AG in infection diseases patients without renal failure and ketoacidosis. Durmuş U et al revealed that lactate clearance in AEOPD patients with hospitalization (severe patients) was signi cantly lower than in AECOPD patients without hospitalization (non-severe patients) [46]. Taken together, these results indicate that bacterial infection and systemic in ammation in non-eosinophilic AECOPD were more severe than in eosinophilic AECOPD.…”

Section: Discussionmentioning

confidence: 92%

Clinical differences between eosinophilic and non-eosinophilic acute exacerbation of chronic obstructive pulmonary disease (AECOPD), a multicenter cross-sectional study

Dai

Ran

Wang

et al. 2020

Preprint

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Background AECOPD is highly heterogeneous with respect to etiology and inflammation. COPD with higher blood eosinophils is associated with increased readmission rates and better corticosteroid response. However, the clinical features of eosinophilic AECOPD aren’t well explored. Then, the aim of this study was to investigate the clinical differences between eosinophilic and non-eosinophilic AECOPD. Methods A total of 643 AECOPD patients were enrolled in this multicenter cross-sectional study. Finally, 455 were included, 214 in normal eosinophils AECOPD (NEOS-AECOPD) group, 63 in mild increased eosinophils AECOPD (MEOS-AECOPD) group, and 138 in severe increased eosinophils AECOPD (SEOS-AECOPD) group. Then, demographic data, underlying diseases, symptoms, and laboratory findings were collected. Multiple logistic regression was performed to identify the independent factors associated with blood EOS. Correlations between blood EOS and its associated independent factors were evaluated. Results The significant differences in 19 factors, including underlying disease, clinical symptom, and laboratory parameters, were identified by univariate analysis. Subsequently, multiple logistic regression revealed that lymphocytes%, neutrophils% (NS%), procalcitonin (PCT), and anion gap (AG) were associated with blood EOS in AECOPD. Both blood EOS counts and EOS% significantly correlated with lymphocytes%, NS%, PCT, and AG. Conclusions The blood EOS was independently associated with lymphocytes%, NS%, PCT, and AG in AECOPD patients. Lymphocytes% was lower, and, NS%, PCT, and AG were higher in eosinophilic AECOPD. Our results indicate that viral dominant infections probably were the major etiology of eosinophilic AECOPD. Non-eosinophilic AECOPD was more likely associated with bacterial dominant infections. The systemic inflammation in non-eosinophilic AECOPD was more severe.

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“…Biomarkers can not only be used for the construction of diagnostic models but also provide available information on the disease’s progress. For example, lactic acid is produced in large amounts in AECOPD patients due to their poor ability to breathe, which leads to the limitation of oxygen and enhancement of glycolysis. , A serum uric acid level that increases significantly during hypoxia is associated with a higher risk of AECOPD and hospitalizations . Malondialdehyde concentrations are also elevated in AECOPD, requiring hospitalizations compared with stable COPD .…”

Section: Results and Discussionmentioning

confidence: 99%

Plasmonic Alloys Enhanced Metabolic Fingerprints for the Diagnosis of COPD and Exacerbations

Su,

Song,

Yang

et al. 2024

ACS Cent. Sci.

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Accurate diagnosis of chronic obstructive pulmonary disease (COPD) and exacerbations by metabolic biomarkers enables individualized treatment. Advanced metabolic detection platforms rely on designed materials. Here, we design mesoporous PdPt alloys to characterize metabolic fingerprints for diagnosing COPD and exacerbations. As a result, the optimized PdPt alloys enable the acquisition of metabolic fingerprints within seconds, requiring only 0.5 μL of native plasma by laser desorption/ionization mass spectrometry owing to the enhanced electric field, photothermal conversion, and photocurrent response. Machine learning decodes metabolic profiles acquired from 431 individuals, achieving a precise diagnosis of COPD with an area under the curve (AUC) of 0.904 and an accurate distinction between stable COPD and acute exacerbations of COPD (AECOPD) with an AUC of 0.951. Notably, eight metabolic biomarkers identified accurately discriminate AECOPD from stable COPD while providing valuable information on disease progress. Our platform will offer an advanced nanoplatform for the management of COPD, complementing standard clinical techniques.

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The value of lactate clearance in admission decisions of patients with acute exacerbation of COPD

Cited by 7 publications

References 16 publications

Relationship between lactate level and length of hospital stay in patients with a COPD exacerbation

Relationship between lactate level and length of hospital stay in patients with a COPD exacerbation

Clinical differences between eosinophilic and non-eosinophilic acute exacerbation of chronic obstructive pulmonary disease (AECOPD), a multicenter cross-sectional study

Plasmonic Alloys Enhanced Metabolic Fingerprints for the Diagnosis of COPD and Exacerbations

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