The value of lipoprotein (a), homocysteine, and Doppler of carotid and femoral arteries in assessment of atherosclerosis in asymptomatic cardiovascular risk patients

El-Gendi, Salwa S.; Bakeet, Madeeha Y.; El-Hamed, E. Abu; Ibrahim, Fatihea K.; Ahmed, Randa

doi:10.1016/j.jjcc.2008.08.001

Cited by 20 publications

(20 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are in line with previous evidence of a modest impact of Lp (a) levels on carotid plaque morphology. For instance, no association between the Lp (a) and carotid intima‐media thickness (IMT) in different populations was reported . These observations indicate a high heterogeneity of atherosclerotic plaques at different arterial districts (ie carotid vs coronary atherosclerotic plaques).…”

Section: Discussionmentioning

confidence: 99%

Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis

Rigamonti

Carbone

Bonaventura

et al. 2018

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis

Rigamonti

Carbone

Bonaventura

et al. 2018

Eur J Clin Investigation

View full text Add to dashboard Cite

show abstract

“…6 Furthermore, previous studies examining the associations of Lp(a) concentrations with carotid artery intima-media thickness and flow-mediated arterial dilation failed to demonstrate significant associations. [7][8][9][10][11][12][13] Understanding the effects of Lp(a) at different arterial sites may be informative about the mechanisms by which Lp(a) causes vascular disease and have relevance for potential therapies to lower Lp(a) levels for the prevention of atherothrombotic disease.…”

Section: Clinical Perspective On P 73mentioning

confidence: 99%

Lipoprotein(a) Genetic Variants Associated With Coronary and Peripheral Vascular Disease but Not With Stroke Risk in the Heart Protection Study

Hopewell

Clarke

Parish

et al. 2011

Circ Cardiovasc Genet

View full text Add to dashboard Cite

Background— Genetic studies have identified 2 single-nucleotide polymorphisms (SNPs) at the LPA locus (rs3798220 and rs10455872) that are strongly and independently related to lipoprotein(a) levels and to coronary disease risk, but their relevance for other atherothrombotic disease is uncertain. Methods and Results— These 2 LPA SNPs were examined together as an LPA genotype score for associations with vascular outcomes among participants in the Heart Protection Study. The LPA score was examined first in 12 236 participants with prevalent vascular disease (9277 coronary disease cases, and 1326 ischemic stroke and 2011 peripheral vascular disease cases with no history of coronary disease) and 3687 vascular disease-free controls and, subsequently, in 3251 participants who had incident major vascular events during follow-up (2106 coronary disease, 507 ischemic stroke, and 707 peripheral vascular disease events). For prevalent disease, the LPA score was strongly associated with coronary disease (odds ratio [OR] per variant allele, 1.19; 95% CI, 1.08 to 1.30) and peripheral vascular disease (OR, 1.18; 95% CI, 1.04 to 1.34) but not with ischemic stroke (OR, 1.03; 95% CI, 0.89 to 1.20). Similarly, for incident disease, the LPA score was strongly associated with coronary disease (hazard ratio [HR], 1.19; 95% CI, 1.09 to 1.30) and peripheral vascular disease (HR, 1.20; 95% CI, 1.02 to 1.40) but not with ischemic stroke (HR, 0.83; 95% CI, 0.67 to 1.03). Conclusions— The comparable strength of associations of the LPA score with coronary disease and peripheral vascular disease but not with stroke suggest that lipoprotein(a) may have effects on atherothrombotic vascular disease that are only relevant at specific sites. Clinical Trial Registration— URL: http://isrctn.org . Unique identifier: ISRCTN48489393.

show abstract

“…Lp(a) possesses a high degree of homology with plasminogen and is a known risk factor for cardiovascular disease 10,11) . In addition, Lp(a) is involved in inflammatory cell adhesion and migration as well as the uptake of macrophage foam cells into the arterial wall and inactivation of tissue-factor pathway inhibitors 12) .…”

Section: Discussionmentioning

confidence: 99%

“…The serum level of hs-CRP is also an independent risk factor for cardiovascular disease, regardless of the LDLcholesterol level [7][8][9] . Lipoprotein(a) (Lp(a)) has a high degree of homology with plasminogen and is also a risk factor for cardiovascular disease 10,11) . Lp(a) is involved in the adhesion of inflammatory cells and migration and uptake of macrophage foam cells into the arterial wall 12) , and the Lp(a) level is positively associated with CAD events 13) .…”

Section: Introductionmentioning

confidence: 99%

High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine are Risk Factors for Coronary Artery Disease in Japanese Patients with Peripheral Arterial Disease

Kumakura

Fujita

Kanai

et al. 2015

JAT

View full text Add to dashboard Cite

Aim:The goal of the study was to investigate the relationships between coronary artery disease (CAD) and risk factors, including the serum levels of high-sensitivity C-reactive protein (hs-CRP), lipoprotein(a) (Lp(a)) and homocysteine, in Japanese patients with peripheral arterial disease (PAD). Methods: Coronary angiography was performed in 451 patients with PAD, among whom the prevalence and clinical characteristics of CAD were analyzed. A multiple logistic analysis was used to evaluate the relationships between CAD and the risk factors. The relationships between the severity of coronary arterial lesions and the risk factors were evaluated using multiple regression analysis. Results: The prevalence of CAD (≥ 70% luminal diameter narrowing or a history of CAD) and coronary artery stenosis (≥ 50%) was 55.9% and 74.1%, respectively, and the rate of CAD (≥ 70%) with single-, double-and triple-vessel disease was 25.9%, 13.5% and 10.6%, respectively. The prevalence of diabetes was higher among the patients with CAD than among those without. The serum levels of hs-CRP, Lp(a), and homocysteine were higher in the patients with CAD, whereas the estimated glomerular filtration rates and HDL-cholesterol levels were lower in these patients. According to the multiple logistic analysis, CAD was related to diabetes (hazard ratio [

show abstract

The value of lipoprotein (a), homocysteine, and Doppler of carotid and femoral arteries in assessment of atherosclerosis in asymptomatic cardiovascular risk patients

Cited by 20 publications

References 56 publications

Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis

Serum lipoprotein (a) predicts acute coronary syndromes in patients with severe carotid stenosis

Lipoprotein(a) Genetic Variants Associated With Coronary and Peripheral Vascular Disease but Not With Stroke Risk in the Heart Protection Study

High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine are Risk Factors for Coronary Artery Disease in Japanese Patients with Peripheral Arterial Disease

Contact Info

Product

Resources

About