The Value of Magnetic Resonance Imaging in Catheter Ablation of Atrial Fibrillation

Gu, Jun; Hu, Wei; Liu, Xu

doi:10.1002/clc.22360

Cited by 6 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unfortunately, further work with MRI still has not yet identified ‘gaps’ in ablation line creation by radiofrequency. The goal would be to identify sites for repeat procedures, and therefore to achieve ablation success [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging Post Robotic Radiosurgical Pulmonary Vein Isolation (RRPVI). First Case in the World.

Monroy¹,

Azpiri²,

Peña³

et al. 2016

Cureus

View full text Add to dashboard Cite

Pulmonary vein isolation using robotic radiosurgery system CyberKnife is a new non-invasive treatment of atrial fibrillation, currently in clinical phase. Robotic radiosurgical pulmonary vein isolation (RRPVI) uses stereotactic, non-invasive (painless) pinpoint radiation energy delivery to a small, precise area to accomplish ablation. The purpose of this report is to describe the finding of an increase in the enhancement of the left atrium demonstrated with the use of cardiac magnetic resonance imaging using late gadolinium enhancement (LGE-CMR) as a result of RRPVI in the first case in the world in humans using CyberKnife as a treatment for paroxysmal atrial fibrillation (PAF).

show abstract

Section: Discussionmentioning

confidence: 99%

Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging Post Robotic Radiosurgical Pulmonary Vein Isolation (RRPVI). First Case in the World.

Monroy¹,

Azpiri²,

Peña³

et al. 2016

Cureus

View full text Add to dashboard Cite

show abstract

“…Atrial fibrillation (AF), the most prevalent arrhythmia, is a risk factor for stroke (1,2). Evidence indicates that subclinical hyperthyroidism is associated with AF, heart failure and coronary disease events (3).…”

Section: Introductionmentioning

confidence: 99%

Role of matrix metalloproteinase-7 and apoptosis-associated gene expression levels in the pathogenesis of atrial fibrosis in a Beagle dog model

Jia

Lin

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

The aim of the present study was to investigate the potential role of matrix metalloproteinase‑7 (MMP‑7) and apoptosis‑associated genes [TIMP metallopeptidase inhibitor 2(TIMP‑2), BCL2 associated X, apoptosis regulator (BAX) and BCL2, apoptosis regulator (BCL‑2)] in the pathogenesis of atrial fibrillation (AF) in a Beagle dog model. A total of 20 adult male Beagle dogs were randomly assigned into the AF group (n=10; Beagle dogs were treated by Burst stimulation to induce AF) and the control group (n=10; healthy Beagle dogs). Echocardiography and Mallory staining were used to determine cardiac function and degree of atrial fibrosis, respectively. Reverse transcription‑quantitative polymerase chain reaction and western blotting were performed to determine collagen type 1 (Col I), MMP‑7, TIMP‑2, BAX and BCL‑2 mRNA and protein expression levels. Compared with the control group, the AF group presented increased degree of atrial fibrosis and level of Col I expression, elevated MMP‑7 and BAX expression levels, but decreased TIMP‑2 and BCL‑2 expression levels. Correlation analysis demonstrated that MMP‑7 and BAX protein expression levels were negatively correlated with left ventricular ejection fraction (LVEF), but positively correlated with the degree of atrial fibrosis. Negative correlation was observed between TIMP‑2 and BCL‑2 protein expression levels and degree of atrial fibrosis. In addition, a positive correlation between TIMP‑2 and BCL‑2 protein expression levels and LEVF was observed. These results demonstrate that MMP‑7 and BAX were highly expressed, while TIMP‑2 and BCL‑2 were downregulated in a Beagle dog model of AF, indicating that MMP‑7 and apoptosis‑associated genes (TIMP‑2, BAX and BCL‑2) may be associated with the pathogenesis of AF.

show abstract

“…This is dependent on uptake of gadolinium by the cardiac tissue, and it is retained for longer periods in fibrotic cells compared to normal cells. Thus areas of damaged myocardium appear hyper-intense relative to the normal myocardium 30 . Indeed more fibrosis has been associated with increased recurrence following the ablation.…”

Section: Quantification Of Fibrosis With Imaging and Relationship To Ablation Successmentioning

confidence: 98%

“…This form of early fibrosis could be potentially reversible and therefore scanning the patients following the ablation can allow us to see whether the diffuse fibrosis has stabilised, progressed or even regressed. Certainly if it has stabilised or regressed this would be a better situation, or if it has progressed we will know at least that the patients will be more at risk of a recurrence and ensure closer monitoring 26 , 30 .…”

Section: Quantification Of Fibrosis With Imaging and Relationship To Ablation Successmentioning

confidence: 99%

The role of myocardial fibrosis in determining the success rate of ablation for the treatment of atrial fibrillation

Selvendran

Aggarwal

et al. 2017

Minerva Cardiol Angiol

View full text Add to dashboard Cite

The Value of Magnetic Resonance Imaging in Catheter Ablation of Atrial Fibrillation

Cited by 6 publications

References 45 publications

Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging Post Robotic Radiosurgical Pulmonary Vein Isolation (RRPVI). First Case in the World.

Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging Post Robotic Radiosurgical Pulmonary Vein Isolation (RRPVI). First Case in the World.

Role of matrix metalloproteinase-7 and apoptosis-associated gene expression levels in the pathogenesis of atrial fibrosis in a Beagle dog model

The role of myocardial fibrosis in determining the success rate of ablation for the treatment of atrial fibrillation

Contact Info

Product

Resources

About