The value of measuring anti-Mullerian hormone in women with anovulatory polycystic ovary syndrome undergoing laparoscopic ovarian diathermy

Amer, Saad; Li, Tin‐Chiu; Ledger, William

doi:10.1093/humrep/dep271

Cited by 94 publications

(111 citation statements)

References 19 publications

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“…Our group and several other researchers have previously reported a significant reduction in serum anti-Müllerian hormone (AMH) after LOD (Weerakiet et al 2007, Amer et al 2009, Elmashad 2011 Reproduction (2017) 154 R13-R21…”

Section: Introductionmentioning

confidence: 90%

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The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis

Amer¹,

Shamy²,

James³

et al. 2017

Reproduction

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Laparoscopic ovarian drilling (LOD) has been widely used as an effective treatment of anovulatory women with polycystic ovarian syndrome (PCOS). However, there has been a growing concern over a possible damaging effect of this procedure on ovarian reserve. The objective of this study was to investigate the hypothesis that LOD compromises ovarian reserve as measured by post-operative changes in circulating anti-Müllerian hormone (AMH). This meta-analysis included all cohort studies as well as randomised controlled trials (RCTs) investigating serum AMH concentrations and other ovarian reserve markers in women with PCOS undergoing LOD. Various databases were searched including MEDLINE, EMBASE, Dynamed Plus, ScienceDirect, TRIP database, ClinicalTrials.gov and Cochrane Library from January 2000 to December 2016. Sixty studies were identified, of which seven were deemed eligible for this review. AMH data were extracted from each study and entered into the RevMan software to calculate the weighted mean difference (WMD) between pre-and post-operative values. Pooled analysis of all studies (n = 442) revealed a statistically significant decline in serum AMH concentration after LOD (WMD −2.13 ng/mL; 95% confidence interval (CI) −2.97 to −1.30). Subgroup analysis based on duration of follow-up, AMH kit, laterality of surgery and amount of energy applied during LOD consistently showed a statistically significant fall in serum AMH concentration. In conclusion, although LOD seems to markedly reduce circulating AMH, it remains uncertain whether this reflects a real damage to ovarian reserve or normalisation of the high pre-operative serum AMH levels. Further long-term studies on ovarian reserve after LOD are required to address this uncertainty.Reproduction (2017) 154 R13-R21

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Section: Introductionmentioning

confidence: 90%

“…of serum AMH was missing as data were presented as median and range (Amer et al 2009, Sunj et al 2014a. The mean ± s.d.…”

Section: Study Selectionmentioning

confidence: 99%

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis

Amer¹,

Shamy²,

James³

et al. 2017

Reproduction

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“…Finally, earlier studies have found that increased AMH levels in PCOS are not only correlated with the increased number of small preantral follicles, but also to some intrinsic abnormality of granulosa cell function (24). These findings may signify that in some way, AMH levels express the severity of the disorder probably reflecting the severity of derangement in folliculogenesis (24). Also, these data are similar but different from other data that in women undergoing laparoscopic ovarian diathermy, the women who became ovulatory had lower levels of serum AMH before treatment (25).…”

Section: Figurementioning

confidence: 87%

“…In addition, in PCOS, serum levels of AMH generally correlate with serum androgens and with insulin (21-23), which also relate to the more severe phenotypes. Finally, earlier studies have found that increased AMH levels in PCOS are not only correlated with the increased number of small preantral follicles, but also to some intrinsic abnormality of granulosa cell function (24). These findings may signify that in some way, AMH levels express the severity of the disorder probably reflecting the severity of derangement in folliculogenesis (24).…”

Section: Figurementioning

confidence: 92%

“…It is well known that AMH levels are higher in women with PCOS compared with normal control subjects of similar age (20)(21)(22)(23)(24) and that among women with various phenotypes of PCOS, the anovulatory group of women have the highest AMH values (22). In addition, in PCOS, serum levels of AMH generally correlate with serum androgens and with insulin (21-23), which also relate to the more severe phenotypes.…”

Section: Figurementioning

confidence: 99%

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Does the level of serum antimüllerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?

Carmina

Campagna

Mansuet

et al. 2012

Fertility and Sterility

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Objective: To determine possible prediction of regular menses with aging in anovulatory women with polycystic ovary syndrome (PCOS). Design: Cohort. Setting: Academic practice. Patient(s): A total of 54 anovulatory women with PCOS and 28 age-and weight-matched control subjects. Intervention(s): Blood and ovarian ultrasound at baseline and after 5 years. Major Outcome Measure(s): Serum antim€ ullerian hormone (AMH), gonadotropins, androgens, insulin sensitivity, and ovarian ultrasound. Result(s): After 5 years, there was a significant decrease in AMH in women with PCOS and control subjects (10 of 54 anovulatory women became ovulatory after 5 years). There was a significant negative correlation between baseline serum AMH and ovulatory function after 5 years. However, baseline serum AMH %4 ng/mL was associated with ovulatory function. Conclusion(s): Serum AMH may help predict ovulatory function with aging in anovulatory women with PCOS. (Fertil Steril Ò 2012;98:1043-6. Ó2012 by American Society for Reproductive Medicine.)

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Decrease in serum anti‐Müllerian hormone level per puncture with laparoscopic ovarian drilling using ultrasonically activated device

Ogawa¹,

Atsuki²,

Shimada³

et al. 2021

Reprod Medicine & Biology

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Laparoscopic ovarian drilling (LOD) has been widely used to treat polycystic ovary syndrome (PCOS). [1][2][3][4][5][6] In general, the clinical results indicate that LOD restores menstrual cyclicity and ovulation in approximately 70-80% of patients, and pregnancy rate following LOD is approximately 40-60%. 2,3,6,7 There was no statistically significant difference in pregnancy or miscarriage rates between LOD and gonadotropin therapy. 3,7 LOD is performed through various methods: electrocautery; lasers including CO 2 , argon, KTP, and Nd-YAG; and ultrasonically activated devices. 2,[8][9][10] In LOD using electrocautery, power setting, duration of

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The value of measuring anti-Mullerian hormone in women with anovulatory polycystic ovary syndrome undergoing laparoscopic ovarian diathermy

Abstract: Pretreatment circulating AMH level seems to be a good predictor of the ovarian response to LOD.

Cited by 94 publications

References 19 publications

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis

The impact of laparoscopic ovarian drilling on AMH and ovarian reserve: a meta-analysis

Does the level of serum antimüllerian hormone predict ovulatory function in women with polycystic ovary syndrome with aging?

Decrease in serum anti‐Müllerian hormone level per puncture with laparoscopic ovarian drilling using ultrasonically activated device

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