The value of outflow tract flow tracing in early pregnancy in the screening of structural malformations of fetal cardiac great arteries

Xia, Yan; Wang, Faxuan; Zhao, Yuan; Liyan, Feihai; Ye, Cailin; Ji, Xueqin

doi:10.21037/atm-21-6475

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Abnormalities in the cardiac OFT are among the most prevalent congenital heart diseases, affecting approximately 22.7% of individuals. These abnormalities may be indicative of intricate morphogenetic events that occur during fetal heart development ( 24 ). The proper development of the conotruncus, the embryonic precursor of the OFT, is crucial for normal cardiac development.…”

Section: Discussionmentioning

confidence: 99%

Novel hub genes and regulatory network related to ferroptosis in tetralogy of Fallot

Wang,

Yang,

et al. 2023

Front. Pediatr.

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Ferroptosis is a newly discovered type of cell death mainly triggered by uncontrolled lipid peroxidation, and it could potentially have a significant impact on the development and progression of tetralogy of Fallot (TOF). Our project aims to identify and validate potential genes related to ferroptosis in TOF. We obtained sequencing data of TOF from the GEO database and ferroptosis-related genes from the ferroptosis database. We employed bioinformatics methods to analyze the differentially expressed mRNAs (DEmRNAs) and microRNAs between the normal control group and TOF group and identify DEmRNAs related to ferroptosis. Protein–protein interaction analysis was conducted to screen hub genes. Furthermore, a miRNA–mRNA–TF co-regulatory network was constructed to utilize prediction software. The expression of hub genes was further validated through quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR). After conducting the differential gene analysis, we observed that in TOF, 41 upregulated mRNAs and three downregulated mRNAs associated with ferroptosis genes were found. Further Gene Ontology/Kyoto Encyclopedia of Genes and Genomes analysis revealed that these genes were primarily involved in molecular functions and biological processes related to chemical stress, oxidative stress, cellular response to starvation, response to nutrient levels, cellular response to external stimulus, and cellular response to extracellular stimulus. Furthermore, we constructed a miRNA–mRNA–TF co-regulatory network. qRT-PCR analysis of the right ventricular tissues from human cases showed an upregulation in the mRNA levels of KEAP1 and SQSTM1. Our bioinformatics analysis successfully identified 44 potential genes that are associated with ferroptosis in TOF. This finding significantly contributes to our understanding of the molecular mechanisms underlying the development of TOF. Moreover, these findings have the potential to open new avenues for the development of innovative therapeutic approaches for the treatment of this condition.

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Section: Discussionmentioning

confidence: 99%

Novel hub genes and regulatory network related to ferroptosis in tetralogy of Fallot

Wang,

Yang,

et al. 2023

Front. Pediatr.

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“…The majority of population-based investigations have indicated a low rate of prenatal identification of newborns with outflow tract anomalies (5,6). Tertiary institutional findings are more encouraging, with greater diagnostic accuracy (7,8).…”

Section: Discussionmentioning

confidence: 99%

Establishing Normal Range of Fetal Pulmonary Artery and Fetal Aortic Diameter in 18-26 Weeks of Gestation in Pakistani Population

Nadeem¹,

Malik²,

Niazi³

et al. 2022

PJMHS

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Congenital heart diseases constitute almost 0.8 to 1.2% of newborn illnesses globally however unfortunately 64% of them remained undiagnosed on conventional anamoly scan which uses four chamber view for cardiac evaluation. In developed countries, other than routine anomaly scan, the three vessel view(3VV) has been added to look for any potential outflow tract anomalies which increased the sensitivity of screening CHD however this view is not routinely used in our clinical practice due to lack of expertise and less awareness regarding the importance of this view . We aimed to establish normal reference values of fetal pulmonary and fetal aorta diameter value using 3VV so that its routine use can increase diagnostic accuracy of anamoly scan in our population. Methodology: This is a non probability convenient study investigating healthy pregnant females between 18-26weeks of gestation conducted from 04-02-2022 to 04-08-2022. After formal ethical approval, 56 patients were included in the study. After achieving 3VV,fetal pulmonary artery and fetal aorta diameter were evaluated and mean values were calculated for each gestational week. Results: The mean age of pregnant females included is 27.3 + 4.4 years (range 20 -37 years). The pulmonary artery diameter ranged from 2.3mm at 18 week of gestation to 3.6mm at 26 week of gestation. Fetal PAD is observed to correlate linearly (r=0.887) with gestational age and linear regression equation derived as PAD= (-0.52) +0.15(GA). Mean fetal aortic diameter was calculated ranged from 1.5mm at 18 week of gestation to 1.6mm at 26week of gestation. Fetal aorta diameter correlation with gestational was found to be 0.164 showing weak correlation along with insignificant regression analysis hence the regression equation cannot be formulated for fetal aorta. Conclusion: Normal mean values of fetal pulmonary artery and fetal aorta from 18-26weeks of gestation were calculated. Linear relationship was found between pulmonary artery diameter and gestational age. However weak correlation noted between fetal aorta diameter and gestational age was noted. Keywords: Fetal pulmonary artery; fetal aorta; anamoly scan; three vessel view(3VV); normal range.

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The value of outflow tract flow tracing in early pregnancy in the screening of structural malformations of fetal cardiac great arteries

Cited by 2 publications

References 15 publications

Novel hub genes and regulatory network related to ferroptosis in tetralogy of Fallot

Novel hub genes and regulatory network related to ferroptosis in tetralogy of Fallot

Establishing Normal Range of Fetal Pulmonary Artery and Fetal Aortic Diameter in 18-26 Weeks of Gestation in Pakistani Population

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