The value of plasma cholinesterase in children with severe liver disease

Popović, Ljiljana; Mikecin, Lili; Kern, Josipa

doi:10.1097/eja.0b013e32831c880c

Cited by 3 publications

(1 citation statement)

References 9 publications

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“…In our study, in children with liver disease, the values of PChE and albumin were not correlated and confirm the data of the independence of PChE and albumin synthesis by the liver [1,6,12].…”

Section: Discussionsupporting

confidence: 77%

Intractable blood loss during brain tumour surgery in a child: effect of recombinant activated factor VII

Nguyễn¹,

Jansen²,

Henny³

et al. 2009

European Journal of Anaesthesiology

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Section: Discussionsupporting

confidence: 77%

Intractable blood loss during brain tumour surgery in a child: effect of recombinant activated factor VII

Nguyễn¹,

Jansen²,

Henny³

et al. 2009

European Journal of Anaesthesiology

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Essentials of Hepatology

Squires¹,

Squires²,

Davis³

2019

A Practice of Anesthesia for Infants and Children

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Butyrylcholinesterase as a Blood Biomarker in Neuroblastoma

Coulter

Boettner

Kortylewicz

et al. 2017

Journal of Pediatric Hematology/Oncology

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Blood-based biomarkers are important in the detection of the disease and in the assessment of responses to therapy. In this study, butyrylcholinesterase was evaluated as a potential biomarker in newly diagnosed neuroblastoma (NB) patients at diagnosis and longitudinally during treatment. Plasma butyrylcholinesterase activities in age-matched and sex-matched children were used as controls. Pretreatment butyrylcholinesterase levels in NB subjects are on an average 2 times lower than butyrylcholinesterase levels in healthy subjects. Significantly, butyrylcholinesterase activities are ∼40% lower in MYCN-amplified as compared with nonamplified disease. As the course of chemotherapy progresses, butyrylcholinesterase activities recover and normalize to control values. The evident response to treatment indicates that plasma butyrylcholinesterase is a good biomarker of tumor response to therapy. Depressed butyrylcholinesterase levels in NB subjects are not caused by hepatic deficits suggesting a specific role for butyrylcholinesterase in NB. Further examination of the mechanism of altered butyrylcholinesterase production require an animal model that best approximates human condition. Studies in mice show that murine NB allografts significantly reduce butyrylcholinesterase activity in plasma. This finding correlates with changes observed in NB patients. In contrast, human NB xenografts produce the opposite effect, that is, butyrylcholinesterase plasma levels rise as the xenograft size increases. In the absence of any liver damage, dissimilarities between butyrylcholinesterase production in murine and human NB models suggest species-specific signaling pathways. This disparity also suggests that human NB xenograft mouse models do not approximate the human disease.

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The value of plasma cholinesterase in children with severe liver disease

Cited by 3 publications

References 9 publications

Intractable blood loss during brain tumour surgery in a child: effect of recombinant activated factor VII

Intractable blood loss during brain tumour surgery in a child: effect of recombinant activated factor VII

Essentials of Hepatology

Butyrylcholinesterase as a Blood Biomarker in Neuroblastoma

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