The value of platelet-rich plasma-derived extracellular vesicles in modern medicine

Hou, Ya; Wen, Xiaoyun; Zhou, Liang; Fang, Xiansong

doi:10.1080/07853890.2023.2287705

Cited by 6 publications

(1 citation statement)

References 85 publications

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“…For a more autologous source, PRP can be of interest, though it might not be as scalable as milk. PRP has been gaining wide momentum as a therapeutic for numerous conditions, and PRP‐derived EVs have shown promise for OA applications both in vitro and in vivo (Hou et al., 2023 ; Liu et al., 2019 ; Zhang et al., 2022 ). However, EVs from biological fluids remain less documented and there is still a lot to answer in terms of properties, functions, and overall yield.…”

Section: Sourcing Extracellular Vesicles: Where Should the Vesicles C...mentioning

confidence: 99%

Therapeutics of the future: Navigating the pitfalls of extracellular vesicles research from an osteoarthritis perspective

Karoichan,

Boucenna,

Tabrizian

2024

J of Extracellular Vesicle

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Extracellular vesicles have gained wide momentum as potential therapeutics for osteoarthritis, a highly prevalent chronic disease that still lacks an approved treatment. The membrane‐bound vesicles are secreted by all cells carrying different cargos that can serve as both disease biomarkers and disease modifiers. Nonetheless, despite a significant peak in research regarding EVs as OA therapeutics, clinical implementation seems distant. In addition to scalability and standardization challenges, researchers often omit to focus on and consider the proper tropism of the vesicles, the practicality and relevance of their source, their low native therapeutic efficacy, and whether they address the disease as a whole. These considerations are necessary to better understand EVs in a clinical light and have been comprehensively discussed and ultimately summarized in this review into a conceptualized framework termed the nanodiamond concept. Future perspectives are also discussed, and alternatives are presented to address some of the challenges and concerns.

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Section: Sourcing Extracellular Vesicles: Where Should the Vesicles C...mentioning

confidence: 99%

Therapeutics of the future: Navigating the pitfalls of extracellular vesicles research from an osteoarthritis perspective

Karoichan,

Boucenna,

Tabrizian

2024

J of Extracellular Vesicle

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Platelet-rich plasma ameliorates dexamethasone-induced myopathy by suppressing autophagy and enhancing myogenic potential through modulation of Myo-D, Pax-7, and myogenin expression

Safwat,

Abdel Ghaffar,

Eldesoqui

et al. 2024

Tissue and Cell

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Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet‐Rich Plasma: A Literature Review

Gupta,

Wang,

Rapaport

et al. 2024

J of Cosmetic Dermatology

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BackgroundThere are exciting advances in the field of exosomes research as a potential regenerative therapy. Platelet‐rich plasma represents an abundant source of exosomes.AimTo present evidence on the use of platelet‐rich plasma‐derived exosomes in dermatology and discuss current technical limitations.MethodsA literature search was conducted using Embase (Ovid), Web of Science, and ClinicalTrials.gov in June 2024.ResultsPlatelet‐rich plasma‐derived exosomes contain a myriad of growth factors, genetic materials, and lipids that mediate paracrine signaling. Several preclinical studies have demonstrated their potential in wound healing. This includes faster wound contraction in diabetic animal models, as well as enhanced angiogenesis, increased cell proliferation and migration, and protection against hyperglycemic conditions in vitro. A case study reported a topical platelet‐derived exosome product tried successfully in a patient with persistent scalp wounds. In contrast, there is scarce information on the use of platelet‐rich plasma‐derived exosomes in hair growth and skin rejuvenation. Isolation techniques, activation methods, and methods of delivery have not been optimized, which warrants further research. Novel delivery methods, such as hydrogel‐based preparations, may enable the topical application of exosomes.ConclusionExosomes derived from platelet‐rich plasma have demonstrated therapeutic potential. More research is needed to standardize its use.

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The value of platelet-rich plasma-derived extracellular vesicles in modern medicine

Cited by 6 publications

References 85 publications

Therapeutics of the future: Navigating the pitfalls of extracellular vesicles research from an osteoarthritis perspective

Therapeutics of the future: Navigating the pitfalls of extracellular vesicles research from an osteoarthritis perspective

Platelet-rich plasma ameliorates dexamethasone-induced myopathy by suppressing autophagy and enhancing myogenic potential through modulation of Myo-D, Pax-7, and myogenin expression

Therapeutic Potential of Extracellular Vesicles (Exosomes) Derived From Platelet‐Rich Plasma: A Literature Review

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