The value of proton mr-spectroscopy in the differentiation of brain tumours from non-neoplastic brain lesions

Aydın, Hasan; Sipahioğlu, Serkan; Na, Oktay; Altin, Elif; Kizilgöz,; Hekįmoğlu, Baki

doi:10.5334/jbr-btr.470

Cited by 10 publications

(15 citation statements)

References 14 publications

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“…Using both ratios in a retrospective classification (cutoff value, 1.8 for either ratio), all but one patient (97%) would have received a correct diagnosis from the results of Proton MRS. This finding is in accordance with Aydin et al (7) study with multivoxel MR spectroscopy, similar significant differences were found, and using Cho/Cr and Cho/NAA ratios allowed a correct retrospective classification in more than 80% of the cases (7,8). Cho/Cr and NAA/Cr ratios in the recurrent tumor and radiation sequel populations in the current study are in close agreement with those obtained using multivoxel MR spectroscopy in similar populations (9,10), although less overlap between these two populations exists in the current study using multivoxel MR spectroscopy.…”

Section: Discussionsupporting

confidence: 95%

“…Miller et al (11) stated that, spectral patterns do allow reliable differential diagnostic statements to be made when the tissues are composed of either pure tumor or pure necrosis, but the spectral patterns are less definitive when tissues composed of varying degrees of mixed tumor and necrosis. In that study, a Cho/Cr ratio of greater than 1.79 had a sevenfold increased likelihood of being pure tumor (7,11). However, none of the current study patients with lesions classified as radiation sequel had Cho/Cr ratios greater than 1.76, and only three (19%) of the contributing patients with recurrent tumor had ratios slightly less than 1.76 (Table 2).…”

Section: Discussioncontrasting

confidence: 46%

“…Proton MRS has proven to be an important complementary examination in differentiation between brain tumor recurrence and radiation sequel in newly enhancing previously treated brain lesions (7,8).…”

Section: Resultsmentioning

confidence: 99%

“…Thus, indications are that a threshold value of Cho/Cr or Cho/NAA ratios (1.8 in the current study) could be used to indicate the presence of tumor. (5,7,11) reported that, increase in Cho/Cr ratios and a reduction in NAA/Cr ratios after radiation therapy are proportional to radiation dose, by using single-voxel MR spectroscopy. In the current study, the Cho/Cr ratios of lesions related to radiation sequel were significantly higher than those of normal-appearing white matter, whereas the decrease of NAA/Cr ratios was not significant.…”

Section: Discussionmentioning

confidence: 98%

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Sensitivity of Proton MRS in differentiation between tumor recurrence and radiation sequel

Gamal

2015

The Egyptian Journal of Radiology and Nuclear Medicine

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Aim of work: The purpose of this study is to assess the sensitivity of Proton MRS to differentiate between tumor recurrence and newly contrast enhanced radiation sequel. Patients and methods: The study was conducted from May 2011 to June 2014 and the study population included 29 patients, 18 males and 11 females with age ranging from 10 to 68 years old (mean = 39) who had been initially diagnosed with an IC neoplasm. Results: Proton MRS performed over the recurrent contrast enhancing lesions resulted in quantifiable choline, creatine, NAA, and lactate peaks in 28 (97%) of the 29 patients. Lesions in the recurrent or residual tumor group had higher Cho/Cr ratios and higher Cho/Cr ratios. Lesions in the recurrent or residual tumor group also had higher Cho/NAA ratios and higher Cho/ NAA ratios than the normal-appearing white matter of 26 patients (p < 0.0001; SE, 0.08). Lesions in the recurrent or residual tumor group had lower NAA/Cr ratios (p < 0.0001; SE, 0.09) than those in the radiation injury group, and lower NAA/Cr ratios than the normal-appearing white matter of 26 patients (p = 0.075; SE, 0.09). Conclusion: We conclude that Proton MRS has the potential to discriminate between recurrent tumor and radiation sequel in patients with recurrent contrast-enhancing intracranial lesions.

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Section: Discussionsupporting

confidence: 95%

Section: Discussioncontrasting

confidence: 46%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

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Sensitivity of Proton MRS in differentiation between tumor recurrence and radiation sequel

Gamal

2015

The Egyptian Journal of Radiology and Nuclear Medicine

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“…H-MRS has been applied in many brain disorders, such as brain tumors, Alzheimer’s disease, multiple sclerosis, epilepsy, mitochondrial disorders and leukodystrophies [8–10]. …”

Section: Introductionmentioning

confidence: 99%

Proton magnetic resonance spectroscopy of periventricular white matter and hippocampus in obstructive sleep apnea patients

et al. 2013

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SummaryBackgroundThe purpose of this study was to diagnose the hypoxic impairment by Magnetic resonance spectroscopy (MRS), an advanced MR imaging technique, which could not be visualised by routine imaging methods in patients with obstructive sleep apnea (OSA).Material/Methods20 OSA patients and 5 controls were included in this prospective research. MRS was performed on these 25 subjects to examine cerebral hypoxemia in specific regions (periventricular white matter and both hippocampi). Polysomnography was assumed as the gold standard. Statistical analysis was assessed by Mann-Whitney U test and Receiver operating characteristics (ROC) curve for NAA/Cho, NAA/Cr and Cho/Cr ratios.ResultsIn the periventricular white matter, NAA/Cho ratio in OSA patients was significantly lower than in the control group (p<0.05). There were no statistical differences between the OSA and the control group for NAA/Cho, NAA/Cr and Cho/Cr ratios for both hippocampal regions. Additionally, Cho/Cr ratio in the periventricular white matter region of OSA group was higher than in the control group (p<0.05).ConclusionsHypoxic impairment induced by repeated episodes of apnea leads to significant neuronal damage in OSA patients. MRS provides valuable information in the assessment of hypoxic ischemic impairment by revealing important metabolite ratios for the specific areas of the brain.

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Overview of current multiparametric magnetic resonance imaging approach in the diagnosis and staging of prostate cancer

Aydın

Kızılgöz

Tekin

2015

The Kaohsiung J of Med Scie

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The value of proton mr-spectroscopy in the differentiation of brain tumours from non-neoplastic brain lesions

Cited by 10 publications

References 14 publications

Sensitivity of Proton MRS in differentiation between tumor recurrence and radiation sequel

Sensitivity of Proton MRS in differentiation between tumor recurrence and radiation sequel

Proton magnetic resonance spectroscopy of periventricular white matter and hippocampus in obstructive sleep apnea patients

Overview of current multiparametric magnetic resonance imaging approach in the diagnosis and staging of prostate cancer

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