The value of radionuclide hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis of infantile persistent jaundice

Liu, Shengxuan; Huang, Zhihua

doi:10.1007/s11684-010-0099-1

Cited by 7 publications

(2 citation statements)

References 7 publications

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“…However, endoscopy can be of use in aiding diagnostic workup, in addition to duodenal intubation for bile detection. Sampling of Duodenal contents to improve the accuracy of scintigraphy, as gamma camera may not pick up minimal activity, is a step towards improvisation by means of non-imaging method[68]. …”

Section: Investigationsmentioning

confidence: 99%

Biliary atresia: Where do we stand now?

Govindarajan

2016

WJH

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The pathway from clinical suspicion to establishing the diagnosis of biliary atresia in a child with jaundice is a daunting task. However, investigations available help to point towards the correct diagnosis in reasonable time frame. Imaging by Sonography has identified several parameters which can be of utility in the diagnostic work up. Comparison of Sonography with imaging by Nuclear medicine can bring out the significant differences and also help in appropriate imaging. The battery of Biochemical tests, available currently, enable better understanding of the line-up of investigations in a given child with neonatal cholestasis. Management protocols enable standardized care with optimal outcome. The place of surgical management in biliary atresia is undisputed, although Kasai procedure and primary liver transplantation have been pitted against each other. This article functions as a platform to bring forth the various dimensions of biliary atresia.

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Section: Investigationsmentioning

confidence: 99%

Biliary atresia: Where do we stand now?

Govindarajan

2016

WJH

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“…Hepatobiliary scintigraphy is indicated in many clinic conditions including any pathologies of hepatobiliary tree like diagnosis of biliary atresia, acute cholesistitis, biliary leak from operation site, biliary obstruction and some familial diseases 3–7. Diagnostic sensitivity and specificity for diagnosis of biliary atresia is 100% and 75% respectively according to a recent report 8. In this patient we couldn’t recognise the biliary activity of small intestine probably because of acids.…”

Section: Differential Diagnosismentioning

confidence: 85%

Hepatobiliary scintigraphy findings of a patient with polianomaly presenting with icterus

Koç

Balcı²,

Kepenek³

2011

Case Reports

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Accuracy of hepatobiliary scintigraphy for differentiation of neonatal hepatitis from biliary atresia: systematic review and meta-analysis of the literature

et al. 2013

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Hepatobiliary scintigraphy is an important diagnostic modality for work-up of neonatal cholestasis. Therefore, our objective was to evaluate the literature regarding the accuracy of hepatobiliary scintigraphy in differentiating biliary atresia from non-biliary atresia causes of cholestasis (collectively called neonatal hepatitis). Our search included Medline, SCOPUS and Google Scholar. Only studies using Tc-99 m-labeled immunodiacetic acid (IDA) derivatives were included. Overall, 81 studies were included in the meta-analysis. Pooled sensitivity and specificity were 98.7% (range 98.1-99.2%) and 70.4% (range 68.5-72.2%), respectively. Factors that increased specificity included the use of radiotracers with high hepatic extraction, administration of hepatic-inducing drugs (such as phenobarbital), use of a calculated dose/kg and administration of a booster dose in cases of non-excretion of the tracer in the bowel. SPECT imaging and duodenal fluid sampling also had high specificity; however, they need further validation because of the low number of studies. Semiquantitative imaging methods do not seem to have any incremental value. We conclude that hepatobiliary scintigraphy using IDA derivatives can be very useful for diagnostic work-up of neonatal cholestasis. To improve the specificity, several measures can be followed regarding type and dose of the radiotracer and imaging protocols. Non-imaging methods seem to be promising and warrant further validation.

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The value of radionuclide hepatobiliary scintigraphy in combination with determination of bilirubin from duodenal drainage in differential diagnosis of infantile persistent jaundice

Cited by 7 publications

References 7 publications

Biliary atresia: Where do we stand now?

Biliary atresia: Where do we stand now?

Hepatobiliary scintigraphy findings of a patient with polianomaly presenting with icterus

Accuracy of hepatobiliary scintigraphy for differentiation of neonatal hepatitis from biliary atresia: systematic review and meta-analysis of the literature

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