The Value of Serum Amyloid A in the Diagnosis and Management of Ankylosing Spondylitis

Abstract

Objective The present study aimed to explore the clinical value of serum amyloid A (SAA) in the diagnosis, treatment, and assessment of ankylosing spondylitis (AS). Methods Seventy-eight patients with AS were enrolled as the case group, while the control group consisted of 80 healthy individuals enrolled during the same time period. According to the criteria of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), patients in the case group were divided into those in the remission phase (36 patients) and those in the active phase (42 patients). Levels of SAA, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were measured in all enrolled subjects and analyzed. Results SAA levels were significantly higher in the AS group (39.65 ± 12.32 ng/mL) than in the control group (7.64 ± 1.32 ng/mL) (p =0.011) and in patients in the active phase (56.18 ± 17.25 ng/mL) compared with those in the remission phase (20.36 ± 5.36 ng/mL) (p =0.015). The sensitivity and specificity of SAA were 79.49% and 77.50%, respectively. There was a positive correlation between SAA level and the BASDAI grade (r = 0.77, p =0.005), CRP level (r = 0.68, p =0.011), and ESR (r = 0.62, p =0.012). Conclusion Not only is SAA a reliable indicator for the presence of AS, it may also be useful for monitoring the activity of this disease.

Effect of storage temperature and time on erythrocyte sedimentation rate

“…Moreover, in a recent study, ESR was shown to be a strong predictor of mortality from coronary heart disease and appears to be a marker for aggressive forms of the disease [ 7 , 8 ]. Thus, ESR has a diagnostic value in some conditions and allows monitoring of therapeutic interventions in others [ 9 , 10 ]. It also responds to surgical intervention.…”

The potential role of serum amyloid A as biomarker of rheumatic diseases: a systematic review and meta-analysis

“…Eighteen studies were conducted in Asia [ 41 , 42 , 44 – 46 , 48 , 50 , 55 , 57 , 59 – 61 , 65 – 69 , 72 ], six in Europe [ 52 – 54 , 58 , 62 , 64 ], five in America [ 47 , 49 , 51 , 56 , 70 ], two in Africa [ 63 , 71 ], and one in Oceania [ 43 ]. Thirteen study comparators included patients with RA [ 42 , 43 , 47 , 49 , 52 , 55 , 56 , 63 , 65 , 67 , 71 ], five with SLE [ 45 , 46 , 55 , 58 ], five with FMF [ 53 , 57 , 59 , 60 , 66 ], three with Takayasu arteritis (TA) [ 48 , 61 , 69 ], two with AS [ 44 , 68 ], two with SSc [ 54 , 62 ], two with osteoarthritis (OA) [ 52 , 55 ], one with BD [ 41 ], one with Henoch–Schönlein purpura (HSP) [ 50 ], one with spondylarthritis (SpA) [ 51 ], one with polymyalgia rheumatica (PMR) [ 64 ], one with PsA [ 70 ], and one with gout [ 72 ]. Mean RD duration was reported in 14 studies and ranged between 2.7 and 21.7 years [ 43 ...…”

“…The risk of bias was considered low in 25 studies [ 42 – 50 , 52 , 56 – 63 , 65 , 66 , 68 – 72 ] and moderate in the remaining seven [ 41 , 51 , 53 – 55 , 64 , 67 ] (Supplementary Table 2).…”

Evaluation of Serum Amyloid (A) Level in Ulcerative Colitis as a new Predictor of Disease Activity

“…8 Furthermore, the study by Yarur et al, 9 In terms of CRP and SAA levels, there was a statistically substantial distinction between the tested groups (p0.001). 9 Hu et al, 14 The levels of SAA were considerably higher in the active group than the inactive group. In agreement with the present results…”