“… 15 The hepatic stellate cell activation during LF results in increased production of extracellular matrix proteins such as collagen, and the elevated expression of CHI3L1 is closely associated with this process. 16 Therefore, CHI3L1 is considered a biomarker for LF progression. Measuring serum CHI3L1 levels may thus aid in assessing the degree of LF in chronic liver disease (CLD) patients.…”