Purpose This study aims to use teleconsultation to perform pharmaceutical consultations with patients using oral antineoplastic agents, to identify their profile, and carry out activities to support the correct treatment.Methods The telepharmacy flowchart was designed considering the steps of a pharmaceutical consultation. A pilot study was carried out with 66 patients from a military hospital, who had been using oral antineoplastic agents for at least 3 months. Adherence was measured using a self-report semi-structured survey, medication possession ratio (MPR), and the proportion of days covered (PDC). The interventions were carried out through structured phone calls. Results Sixty-seven percent were male, and 33% were aged 65 to 75 years. According to the survey, 16 patients adhered to the oral antineoplastic agent. Based on MPR and PDC, 53 and 52 patients showed good persistence, respectively. When all methods were applied together, 9 patients were adherent. On average, each patient regularly uses 4.73 medicines. Most patients (83 %) reported adverse effects during treatment. Five hundred eighty-one pharmaceutical interventions were carried out, most of them corrective (29%) and related to the correct drug administration technique (29 %).Conclusions The proposed tool helped establish good communication with patients, obtain desired data, and carry out relevant interventions. However, it is necessary to carry out further consultations to verify whether the patients were able to apply the suggested recommendations in practice.