The value of the 1981 who histological classification in inter‐observer reproducibility and changing pattern of lung cancer

Campobasso, O; Andrion, A; Ribotta, Marisa; Ronco, Guglielmo

doi:10.1002/ijc.2910530205

Cited by 32 publications

(23 citation statements)

References 11 publications

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“…Consitent with other reports (22), in the present study, low levels of 5-hmC were more common in patients with lymph node metastases, high histological types and large tumor sizes, which are recognized prognostic factors for lung cancer (23). The proportion of low 5-hmC level in NSCLC patients with lymph node metastases was markedly higher than those patients without lymph node metastases, as well as the histological types and tumor sizes.…”

Section: -Hmc Level ---------------------------------------------------supporting

confidence: 83%

Low level of 5-Hydroxymethylcytosine predicts poor prognosis in non-small cell lung cancer

Liao

et al. 2016

Oncology Letters

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Abstract. The loss of 5-hydroxymethylcytosine (5-hmC) has previously been demonstrated to be implicated in the initiation and progression of various tumors. However, its role in non-small cell lung cancer (NSCLC) remains unknown. The present study aimed to determine the level of 5-hmC in NSCLC and their adjacent normal lung tissues by immunohistochemistry and dot-blot analysis; then the relationship between 5-hmC level and the clinicopathological features of NSCLC and the prognostic significance of 5-hmC level in NSCLC patients were analyzed. By employing the dot-blot analysis, a significant reduction of 5-hmC level in NSCLC tissues compared with the adjacent normal tissues was detected, which were further verified by the immunohistochemistry results on tissue microarrays. Further analyses demonstrated that 65.38% (136/208) presented with low 5-hmC level, and low 5-hmC level was significantly associated with lymph node metastasis (P<0.001), histological type (P<0.001) and large tumor size (P=0.031). Notably, the 5-year overall survival rate of patients with low 5-hmC levels were significantly lower than patients with high 5-hmC levels (P<0.001). In addition, it was demonstrated that 5-hmC level was identified as independent prognostic factor in patients' overall survival. In conclusion, downregulation of 5-hmC may serve as a useful biomarker for NSCLC prognosis evaluation.

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Section: -Hmc Level ---------------------------------------------------supporting

confidence: 83%

Low level of 5-Hydroxymethylcytosine predicts poor prognosis in non-small cell lung cancer

Liao

et al. 2016

Oncology Letters

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“…34) A pathological review study in Italy found that this change in criteria resulted in a 15% increase of adenocarcinoma and an 11% decrease of squamous cell carcinoma in proportion. 41) We are now conducting a similar pathological review study in two major hospitals in Osaka, which cover approximately 20% of all lung cancer cases in Osaka. Preliminary results showed that the impact of this change was not as signifi- cant as expected, and may not exceed 4% difference in the proportion of each histologic type in Japan.…”

Section: Discussionmentioning

confidence: 99%

Trends of Lung Cancer Incidence by Histologic Type: A Population‐based Study in Osaka, Japan

Sobue

Ajiki

Tsukuma

et al. 1999

Japanese Journal of Cancer Research

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We investigated trends of lung cancer incidence from 1974 to 1993 by histologic type, using data from the population-based cancer registry in Osaka, Japan. Since the proportion of cases with histologic types identified was not sufficiently high, sex-and age-specific incidence rates by histologic types were estimated assuming that the distribution of histologic types was the same across the same sex and age group regardless of reporting status. Cumulative risk from 0 to 74 years old for total lung cancer increased 1.3-fold from the period 1974-77 to 1986-89 and then plateaued in the period 1990-93 for both males and females. When divided into histologic types, cumulative risk for incidence of squamous cell carcinoma was almost constant during the study period for both males and females. During the same period, adenocarcinoma increased up to 1.4-fold for both males and females. This increase seemed to have reached a plateau recently for males, but not for females. Small cell carcinoma increased monotonously up to 1.6-to 1.7-fold for both males and females. Large cell carcinoma showed over 2-fold increase for both males and females; however, the estimates fluctuated due to the small number of cases. This study provides further evidence of a relative increase of adenocarcinoma compared to squamous cell carcinoma. Recent trends of tapering increase of lung cancer incidence should be confirmed by further observation.Key words: Lung cancer -Histologic type -Incidence -Trend -Smoking Recent trends of lung cancer incidence are showing different patterns by country. 1) In the US and UK, where lung cancer incidences were relatively high and smoking control has been successfully implemented, incidence of lung cancer in males has reached a peak and now is in the decreasing phase, starting from younger age groups. In contrast, in Eastern Europe, where smoking control has been less successful, the incidence is still increasing. These trends have been greatly influenced by the trends of smoking prevalence. It is well known that the magnitude of association between lung cancer and cigarette smoking differs by histologic types. Squamous cell carcinoma and small cell carcinoma show a 10-to 20-fold increase among current smokers compared to non-smokers, while adenocarcinoma shows a 2-to 5-fold increase.2) Therefore, smoking prevalence influences the trends of incidences differently among histologic types.In the US and Europe, several hospital-based studies, [3][4][5][6] autopsy series 7) and population-based studies [8][9][10][11][12][13][14][15][16] have examined the trends of lung cancer incidence by histologic type. In Asian countries there have been hospitalbased studies, [17][18][19][20] and a population-based study. 21) Most of the studies showed a relative increase of adenocarcinoma as compared to squamous cell carcinoma in both males and females, especially in younger age groups. Lung cancer incidence in Japan has been relatively low compared to other countries. It is reported that cumulative risk (0-74 years old) of lung c...

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“…It has been shown that the agreement between independent histological evaluations of lung cancer varies by calendar time, distribution of ''true'' histological types and edition of WHO classification (1967 versus 1981) [15,17]. Butler et al showed that the overall agreement of histological evaluations of lung cancer in New Mexico was lower for 1970-72 as compared to 1980-81.The rate of confirmation of large-cell carcinoma was lower when the proportion of large-cell carcinoma became larger in the more recent period [15].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies on the diagnostic agreement in the histopathological evaluation of lung cancer tissue have been performed in the past [8][9][10][11][12][13][14][15][16][17][18]. Only very few studies have been performed that compared the agreement of histological lung cancer diagnosis of an unselected population-based lung cancer case series and an independent pathology review [3,12,15,18].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic agreement in the histopathological evaluation of lung cancer tissue in a population-based case-control study

et al. 2006

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The value of the 1981 who histological classification in inter‐observer reproducibility and changing pattern of lung cancer

Cited by 32 publications

References 11 publications

Low level of 5-Hydroxymethylcytosine predicts poor prognosis in non-small cell lung cancer

Low level of 5-Hydroxymethylcytosine predicts poor prognosis in non-small cell lung cancer

Trends of Lung Cancer Incidence by Histologic Type: A Population‐based Study in Osaka, Japan

Diagnostic agreement in the histopathological evaluation of lung cancer tissue in a population-based case-control study

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