The value of the 24-h proteinuria in evaluating the severity of preeclampsia and predicting its adverse maternal outcomes

Li, Boya; Li, Lin; Zhu, Yuanfeng; Wei, Yueguang; Li, Xiaotian; Chen, Dunjin; Zhao, Xin; Cui, Shihong; Ding, Hongjuan; Ding, Guifeng; Meng, Haixia; Wei, Hongwei; Sun, Xiaotong; Xin, Hong

doi:10.1080/10641955.2018.1487564

Cited by 15 publications

(8 citation statements)

References 10 publications

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“…According to the two-stage theory, proteinuria results from kidney damage, during the process of systematic endothelial damage. Thus, PE with proteinuria in early pregnancy may indicate a severe type of PE, 31,32) although this view is somewhat controversial. 33) If our model can detect a severe type of PE before its onset, even if only a subtle improvement in mAUROC (0.769 vs. 0.785) is observed, it will be useful in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

Ohseto

Ishikuro

Obara

et al. 2022

Hypertens Res Pregnancy

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This study aimed to develop a prediction model for preeclampsia (PE) using routinely examined items in early pregnancy, in particular, the dipstick test for proteinuria. Methods: A total of 9,086 pregnant women recruited in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study were included in the present study for analysis. Maternal basic characteristics were obtained by self-report, and blood pressure and dipstick test data were obtained from medical records. The assessed outcome was PE, including superimposed PE. We developed a prediction model without the dipstick test for proteinuria (Model 1) and a model with it (Model 2), and compared the two based on mean area under the receiver operating characteristic curve (mAUROC) using five-fold cross validation. Results: The mAUROC of Model 1 was 0.769 (95% CI: 0.741 to 0.797) and that of Model 2 was 0.785 (95% CI: 0.758 to 0.812). The difference in mAUROC between the two models was 0.016 (95% CI: 0.004 to 0.028). In Model 2, detection rates were 40%, 49%, and 64% at false-positive detection rates of 5%, 10%, and 20%, respectively. Conclusions: We improved a prediction model for PE using routine antenatal care items by including the dipstick test for proteinuria.

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Section: Discussionmentioning

confidence: 99%

Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

Ohseto

Ishikuro

Obara

et al. 2022

Hypertens Res Pregnancy

View full text Add to dashboard Cite

show abstract

“…According to the two-stage theory, proteinuria results from kidney damage, during the process of systematic endothelial damage, so PE with proteinuria in early pregnancy may indicate a severe type of PE 22,23 , which is still controversial 24 . If our model can detect a severe type of PE before its onset, even though the improvement of the mAUROC was subtle (0.769 vs. 0.785), it will be useful in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

Ohseto¹,

Ishikuro²,

Obara³

et al. 2021

Preprint

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ObjectiveThe aim of our study was to develop prediction model for preeclampsia (PE) using routinely examined items in early pregnancy especially dipstick test for proteinuria.MethodThe Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study recruited pregnant women and we included 9,086 of them in analysis. Maternal basic characteristics were obtained by self-report, and blood pressure and dipstick test of proteinuria were obtained by medical record at regular antenatal care. The outcome was defined as PE including superimposed preeclampsia. We developed prediction model without dipstick test of proteinuria (model 1) and model with it (model 2), and we compared them by the mean of area under the receiver operating characteristic curve (mAUROC) using five-fold cross validation.ResultsmAUROC of model 1 was 0.769 (95% CI; 0.741 to 0.797) and that of model 2 was 0.785 (95% CI; 0.758 to 0.812). The difference of two mAUROCs was 0.016 (95% CI; 0.004 to 0.028). In model 2, detection rates at false-positive rate of 5%, 10% and 20% were 40%, 49% and 64%, respectively.ConclusionsWe could develop prediction model for PE using routine antenatal care items and it was improved by including dipstick test for proteinuria.

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“…Investigation of potential risk markers of adverse outcomes had been performed at molecular, biochemical index, and metabolism level (29)(30)(31). Multiple pregnancies are at increased risk of adverse maternal and perinatal outcomes, mainly due to obstetric complications, preterm birth, and birth weight discordance (32).…”

Section: Discussionmentioning

confidence: 99%

Establish Reference Intervals of Complete Blood Count for Twin Pregnancy

Zeng

Mao

et al. 2021

Preprint

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Background: Twin pregnancy is of high risk, which increased in recent years. Establishment of reference intervals of complete blood count (CBC) for twin-pregnant women during pregnancy might help for the properly prognosis of adverse outcomes in twin pregnancy. Methods: We screened out 253 cases of twin pregnancy reference cohort from 1153 twin pregnancy after the complications and adverse pregnancy outcomes were excluded. Complete blood count data were collected during the mid- and late-term of pregnancy and analyzed by SPSS to establish the reference intervals of peripheral blood of twin pregnancy. Results: The RBC, HGB, HCT, and PLT were lower in twin pregnant women than those in healthy nulligravida women during gestation, while the levels of WBC, NEU, and NEU% increased, especially in the mid-term. The reference intervals of late-term pregnancy validated by using 20 samples of twin pregnancy, then utilized for figuring out the distinctive characteristics of CBC with preterm birth (PTB) pregnancy. Absolutes of WBC and NEU increased in PTB pregnancy using our established reference intervals, implying they might be prognosis indicators of this adverse outcome. Conclusion: Establishing the reference interval of blood cell-related indicators of normal twin pregnancy is helpful for the monitoring and prognosis of PTB.

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The value of the 24-h proteinuria in evaluating the severity of preeclampsia and predicting its adverse maternal outcomes

Abstract: The proteinuria ≥ 2 g/24 h is an independent predictive factor of adverse maternal outcomes in preeclampsia, but its individual predictive value is limited. The risk prediction model is effective in assessing the risk of adverse maternal outcomes in patients with HDP.

Cited by 15 publications

References 10 publications

Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

Preeclampsia prediction model using the dipstick test for proteinuria during early gestation

Establish Reference Intervals of Complete Blood Count for Twin Pregnancy

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