The Value of the 8th Edition of American Joint Committee on Cancer Pathological Prognostic Staging on the Selection of Postmastectomy Radiotherapy for T1–2N1 Breast Cancer

Wang, Jun; Luo, Ting; Zeng, Yuanyuan; Tian, Yang; Zheng, Hong; Liu, Lei

doi:10.1155/2022/7550323

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…The end points in this study were locoregional recurrence–free survival (LRFS), distant metastasis–free survival (DMFS), breast cancer–specific survival (BCSS), and overall survival (OS). The definitions of LRFS, DMFS, BCSS, and OS were stated in our previous study [ 19 ].…”

Section: Methodsmentioning

confidence: 99%

Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study

Wang¹,

Luo²,

Zeng³

et al. 2023

JMIR Public Health Surveill

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Background Young breast cancer patients are more likely to develop aggressive tumor characteristics and a worse prognosis than older women, and different races and ethnicities have distinct epidemiologies and prognoses. However, few studies have evaluated the clinical biological features and relapse patterns in different age strata of young women in Asia. Objective We aimed to explore survival differences and the hazard function in young Chinese patients with breast cancer (BC) by age. Methods The patients were enrolled from West China Hospital, Sichuan University. The chi-squared test, a Kaplan-Meier analysis, a log-rank test, a Cox multivariate hazards regression model, and a hazard function were applied for data analysis. Locoregional recurrence–free survival (LRFS), distant metastasis–free survival (DMFS), breast cancer–specific survival (BCSS), and overall survival (OS) were defined as end points. Results We included 1928 young BC patients diagnosed between 2008 and 2019. Patients aged 18 to 25, 26 to 30, 31 to 35, and 36 to 40 years accounted for 2.7% (n=53), 11.8% (n=228), 27.7% (n=535), and 57.7% (n=1112) of the patients, respectively. The diagnosis of young BC significantly increased from 2008 to 2019. Five-year LRFS, DMFS, BCSS, and OS for the entire population were 98.3%, 93.4%, 94.4%, and 94%, respectively. Patients aged 18 to 25 years had significantly poorer 5-year LRFS (P<.001), 5-year DMFS (P<.001), 5-year BCSS (P=.04), and 5-year OS (P=.04) than those aged 31 to 35, 26 to 30, and 36 to 40 years. The hazard curves for recurrence and metastasis for the whole cohort continuously increased over the years, while the BC mortality risk peaked at 2 to 3 years and then slowly decreased. When stratified by age, the annualized hazard function for recurrence, metastasis, and BC mortality in different age strata showed significantly different trends, especially for BC mortality. Conclusions The annual diagnosis of young BC seemed to increase in Chinese patients, and the distinct age strata of young BC patients did not differ in survival outcome or failure pattern. Our results might provide strategies for personalized management of young BC.

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Section: Methodsmentioning

confidence: 99%

Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study

Wang¹,

Luo²,

Zeng³

et al. 2023

JMIR Public Health Surveill

Self Cite

View full text Add to dashboard Cite

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Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study (Preprint)

Wang¹,

Luo²,

Zeng³

et al. 2023

Preprint

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BACKGROUND Young breast cancer patients are more likely to develop aggressive tumor characteristics and worse prognosis than older women, and have distinct epidemiology and prognosis in different races. However, rare studies have evaluated the clinical biological features and relapse patterns according to different age strata of young women in Asia OBJECTIVE To explore the survival difference and hazard function of young breast cancer (BC) by age in Chinese patients. METHODS The patients were enrolled from West China hospital, Sichuan University. Chi-squared test, Kaplane-Meier analysis, log-rank test, cox multivariate hazards regression model, and hazard function were applied for data analyzing. RESULTS We included 1,950 young BC patients diagnosed between 2008 and 2019. Patients aged ≤ 25, 26-30, 31-35, and 36-40 years accounted for 2.8%, 11.7%, 27.6%, and 57.8%, respectively. The diagnosis of young BC significantly increased from 2008 to 2019. Five-year locoregional recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), breast cancer-specific survival (BCSS), and overall survival (OS) for the entire population were 98.3%, 93.4%, 94.3%, and 93.9%, respectively. Patients aged ≤25 years had significantly poorer 5-year LRFS (P<.001), 5-year DMFS (P<.001), 5-year BCSS (P=.04), and 5-year OS (P=.04) than those aged 31-35, 26-30, and 36-40 years. The annualized hazard function for recurrence, metastasis, and BC mortality in all patients and different age strata showed significantly different trends, especially for BC mortality. CONCLUSIONS The annual diagnosis of young BC seemed to increase in Chinese patients, and distinct age-strata of young BC patients didn’t differ for survival outcome and failure patterns.

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The Value of the 8th Edition of American Joint Committee on Cancer Pathological Prognostic Staging on the Selection of Postmastectomy Radiotherapy for T1–2N1 Breast Cancer

Cited by 2 publications

References 29 publications

Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study

Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study

Survival and Trends in Annualized Hazard Function by Age at Diagnosis Among Chinese Breast Cancer Patients Aged ≤40 Years: Case Analysis Study (Preprint)

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