The Value of the Cytokinome Profile

Costantini, Susan; Sharma, Ankush; Colonna, Giovanni

doi:10.5772/25707

Cited by 11 publications

(7 citation statements)

References 75 publications

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“…Since cytokine-mediated communication within the tumor microenvironment is mediated by multiple regulatory networks, cellular stimuli, and cytokine production variations, studying the cytokinome patterns provides an informative network of complex interactions [ 28 ]. Thus, understanding interactions within the tumor microenvironment and cytokinome crosstalk and functions will provide insight into the progression of inflammation-driven cancers.…”

Section: Discussionmentioning

confidence: 99%

Zoledronic Acid Abrogates Restraint Stress-Induced Macrophage Infiltration, PDGF-AA Expression, and Ovarian Cancer Growth

Colon-Echevarria

Ortiz

Maldonado

et al. 2020

Cancers

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Multiple studies suggest that chronic stress accelerates the growth of existing tumors by activating the sympathetic nervous system. Data suggest that sustained adrenergic signaling can induce tumor growth, secretion of pro-inflammatory cytokines, and macrophage infiltration. Our goal was to study the role of adrenergic-stimulated macrophages in ovarian cancer biology. Cytokine arrays were used to assess the effect of adrenergic stimulation in pro-tumoral cytokine networks. An orthotopic model of ovarian cancer was used to assess the in vivo effect of daily restraint stress on tumor growth and adrenergic-induced macrophages. Cytokine analyses showed that adrenergic stimulation modulated pro-inflammatory cytokine secretion in a SKOV3ip1 ovarian cancer cell/U937 macrophage co-culture system. Among these, platelet-derived growth factor AA (PDGF-AA), epithelial cell-derived neutrophil-activating peptide (ENA-78), Angiogenin, vascular endothelial growth factor (VEGF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-5 (IL-5), Lipocalin-2, macrophage migration inhibitory factor (MIF), and transferrin receptor (TfR) were upregulated. Enriched biological processes included cytokine-mediated signaling pathways and positive regulation of cell proliferation. In addition, daily restraint stress increased ovarian cancer growth, infiltration of CD68+ macrophages, and expression of PDGF-AA in orthotopic models of ovarian cancer (SKOV3ip1 and HeyT30), while zoledronic acid, a macrophage-depleting agent, abrogated this effect. Furthermore, in ovarian cancer patients, high PDGFA expression correlated with worse outcomes. Here, it is shown that the adrenergic regulation of macrophages and PDGFA might play a role in ovarian cancer progression.

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Section: Discussionmentioning

confidence: 99%

Zoledronic Acid Abrogates Restraint Stress-Induced Macrophage Infiltration, PDGF-AA Expression, and Ovarian Cancer Growth

Colon-Echevarria

Ortiz

Maldonado

et al. 2020

Cancers

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“…On the other hand, as inflammation can be considered as a physiological response of the immune system to damaged tissues[ 84 ], it is a protective reaction to remove the injurious stimuli and to initiate the healing of damaged tissues[ 84 ]. Nutrition excess slows tissue healing, indeed nutrition derived from the degradation of the damaged tissue coupled with excess nutrition intake will be mostly turned into lipid intermediates and deposited in nonadipose tissue, lipotoxicity and further tissue damage.…”

Section: Gut Microbiome Role In Covid-19 Severitymentioning

confidence: 99%

COVID-19 and the gastrointestinal tract: source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection?

Troisi

Venutolo

Tanyà

et al. 2021

WJG

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Gastrointestinal (GI) symptoms have been described in a conspicuous percentage of coronavirus disease 2019 (COVID-19) patients. This clinical evidence is supported by the detection of viral RNA in stool, which also supports the hypothesis of a possible fecal-oral transmission route. The involvement of GI tract in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is corroborated by the theoretical assumption that angiotensin converting enzyme 2, which is a SARS-CoV-2 target receptor, is present along the GI tract. Studies have pointed out that gut dysbiosis may occur in COVID-19 patients, with a possible correlation with disease severity and with complications such as multisystem inflammatory syndrome in children. However, the question to be addressed is whether dysbiosis is a consequence or a contributing cause of SARS-CoV-2 infection. In such a scenario, pharmacological therapies aimed at decreasing GI permeability may be beneficial for COVID-19 patients. Considering the possibility of a fecal-oral transmission route, water and environmental sanitation play a crucial role for COVID-19 containment, especially in developing countries.

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“…Indeed, adipose tissue has been demonstrated to be an important source of pro-inflammatory cytokines, which can sustain inflammation in many organs, including the gut [ 1 , 3 ]. Inflammation is the natural immune response to tissue damage in the human body [ 11 ]. It is initially protective for the removal of the injurious stimuli and damaged tissues, as well as the initiation of tissue healing [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…Inflammation is the natural immune response to tissue damage in the human body [ 11 ]. It is initially protective for the removal of the injurious stimuli and damaged tissues, as well as the initiation of tissue healing [ 11 ]. However, it becomes problematic when there is overnutrition, which makes inflammation chronic.…”

Section: Introductionmentioning

confidence: 99%

The Mediterranean Diet in Paediatric Gastrointestinal Disorders

et al. 2022

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The Mediterranean diet is considered one of the healthiest dietary patterns worldwide, thanks to a combination of foods rich mainly in antioxidants and anti-inflammatory nutrients. Many studies have demonstrated a strong relationship between the Mediterranean diet and some chronic gastrointestinal diseases. The aim of this narrative review was to analyse the role of the Mediterranean diet in several gastrointestinal diseases, so as to give a useful overview on its effectiveness in the prevention and management of these disorders.

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The Value of the Cytokinome Profile

Cited by 11 publications

References 75 publications

Zoledronic Acid Abrogates Restraint Stress-Induced Macrophage Infiltration, PDGF-AA Expression, and Ovarian Cancer Growth

Zoledronic Acid Abrogates Restraint Stress-Induced Macrophage Infiltration, PDGF-AA Expression, and Ovarian Cancer Growth

COVID-19 and the gastrointestinal tract: source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection?

The Mediterranean Diet in Paediatric Gastrointestinal Disorders

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