The value of the D-Dimer assay for predicting vein thrombosis in rehabilitation patients receiving prophylactic low molecular weight heparin doses

Formisano, Rita; Buzzi, Maria Gabriella; Cicinelli, Paola; Voogt, Robert D.; Rinnenburger, Dagmar; Morelli, Daniela; Terziani, A.; S, Sanguigni; Lorenzo, Luigi Di

doi:10.1080/02699050701716927

Cited by 2 publications

(2 citation statements)

References 28 publications

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“…However, several studies have shown that D-D can only be considered as an exclusion criterion for deep vein thrombosis (DVT) because of its low specificity. 15 , 16 The APTT and PT have high specificity but lack sensitivity; they are plasma-based tests that cannot evaluate clot formation rate, extent of fibrinolysis, or clot lysis. 17 A meta-analysis reported that the rate of missed diagnoses of lower-extremity DVT was at 50%, despite using ultrasound.…”

Section: Introductionmentioning

confidence: 99%

The effect of triple-dose-intravenous tranexamic acid on blood loss in patients undergoing total hip arthroplasty without affecting blood coagulopathy: A prospective thromboelastographic analysis

Jin,

Yan,

Zhang

et al. 2024

Acta Orthopaedica et Traumatologica Turcica

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Objective: This study aimed to assess the safety and efficacy of triple-dose intravenous tranexamic acid (TXA) in patients following total hip arthroplasty (THA) using thromboelastography (TEG). Methods: One hundred thirty patients undergoing THA were prospectively enrolled in the study. According to the intravenous infusion TXA dose, patients were divided into single-dose (n = 65; mean age = 60.8 ± 8.1 years) and triple-dose groups (n = 65; mean age = 61.8 ± 8.6 years). Complete blood count (CBC), conventional coagulation tests (CCT), and TEG were conducted 1 day before the operation, on postoperative day 1 (POD1), and postoperative day 7 (POD7). Color Doppler ultrasonography was performed 1 day before the operation and on POD7. Drainage blood loss, total blood loss (TBL), hidden blood loss (HBL), deep vein thrombosis (DVT) incidence, and blood transfusion rates were calculated and recorded. The CCT, CBC, and TEG parameters were compared between the 2 groups. Results: Single- and triple-dose groups had significantly different hematocrit on POD7 ( P < .05). No significant differences were found in CCT and hemoglobin at any corresponding time point between the 2 groups ( P > .05). Despite the reaction time (R) on POD1 ( P < .05), there were no significant differences in other TEG parameters at any other time point between the 2 groups ( P > 0.05). For drainage blood loss and TBL, the triple-dose group had lesser blood loss than the single-dose group ( P < .05). However, no significant differences were found for blood transfusion rate, HBL, or incidence of DVT ( P > .05). Conclusion: Compared with single-dose, triple-dose TXA can be more effective in decreasing blood loss without increasing DVT incidence in patients undergoing THA. Although there is a notable disparity in the R time on POD1, the administration of triple-dose TXA does not substantially impact the coagulation status as assessed by TEG and CCT. Level of Evidence: Level I, Therapeutic study.

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Section: Introductionmentioning

confidence: 99%

The effect of triple-dose-intravenous tranexamic acid on blood loss in patients undergoing total hip arthroplasty without affecting blood coagulopathy: A prospective thromboelastographic analysis

Jin,

Yan,

Zhang

et al. 2024

Acta Orthopaedica et Traumatologica Turcica

View full text Add to dashboard Cite

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“…Many studies have shown that D-dimer (D-D) has high sensitivity for diagnosing venous thromboembolism (VTE), but with low specificity, and it can only be used as an exclusion criterion for VTE. 10 , 11 Zhang et al 12 reported that the rate of missed diagnosis of lower limb DVT by ultrasound amounts to 50% or so in patients without symptoms of DVT. Considering that the thrombosis may not have formed yet, but the blood coagulopathy has changed, in order to explore the changes in the blood coagulopathy, the parameters of thromboelastography (TEG) were used as the main observation indicators.…”

Section: Introductionmentioning

confidence: 99%

Gender Differences do not Influence the Blood Coagulopathy in Patients Undergoing Total Knee Arthroplasty: A Retrospective Thromboelastography Analysis

Jin

Pang

Zhang

et al. 2021

Clin Appl Thromb Hemost

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Objective Deep vein thrombosis (DVT) is one of the severe complications after total knee arthroplasty (TKA). Gender has been considered to influence the incidence of the thrombosis formation in TKA patients. However, it remains controversial which gender would be more prone to form thrombosis. The aim of this study was to assess the effects of gender differences on coagulation status after TKA via the thromboelastography (TEG). Methods A total of 57 male patients who underwent primary TKA from September 2015 to January 2021 were included in this study. According to the matching principle of age, body mass index (BMI), and anticoagulation treatment, 60 female patients were selected. The conventional coagulation tests, routine blood tests, and thromboelastography were conducted before the operation, 1 day and 7 days after the operation. In addition, Doppler ultrasound was also performed 1 day before the operation and at the 7 days after the operation. The parameters of conventional coagulation tests, routine blood tests, and thromboelastography were compared between the two groups. Results There were no significant differences in the blood transfusion rate, the incidence of DVT during the perioperative period, D-dimer (D-D), fibrin degradation products (FDP), hemoglobin (HB), hematocrit (HCT), prothrombin time (PT), activated partial thromboplastin time (APTT), and C-reactive protein (CRP) at any corresponding time point between the male group and the female group ( P > .05). There were no significant differences in neutrophil-to-lymphocyte ratio (NLR) preoperatively; however, there were significant differences in NLR 1 day after the surgery and 7 days after the surgery between the two groups ( P < .05). There were significant differences in reaction time (R) and α angle 1 day after the surgery between the two groups ( P < .05), but there were no significant differences in other TEG indexes at any corresponding time point between the two groups ( P > .05). Binary logistic regression analysis demonstrated that gender, age, BMI, tourniquet application time were not independent predictors ( P > .05). Conclusion Gender differences have no significant influence in TKA patients with regard to conventional coagulation tests and thromboelastography.

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The value of the D-Dimer assay for predicting vein thrombosis in rehabilitation patients receiving prophylactic low molecular weight heparin doses

Cited by 2 publications

References 28 publications

The effect of triple-dose-intravenous tranexamic acid on blood loss in patients undergoing total hip arthroplasty without affecting blood coagulopathy: A prospective thromboelastographic analysis

The effect of triple-dose-intravenous tranexamic acid on blood loss in patients undergoing total hip arthroplasty without affecting blood coagulopathy: A prospective thromboelastographic analysis

Gender Differences do not Influence the Blood Coagulopathy in Patients Undergoing Total Knee Arthroplasty: A Retrospective Thromboelastography Analysis

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