The Value of the ThinPrep Test for Endometrial Carcinoma Diagnosis: A Large Study Cohort from an Academic Medical Center

Serdy, Kate M.; Yildiz-Aktas, Isil Z.; Zhao, Chengquan

doi:10.1016/j.jasc.2014.09.006

Cited by 9 publications

(21 citation statements)

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“…However, in the current study, 10.7% of patients (6 of 56 patients) with a histologic diagnosis of endometrial carcinoma had positive HPV testing, suggesting that HPV positivity cannot be used to rule out endometrial carcinoma. Consistent with our previous studies and other studies, the data from the current study also demonstrated that endometrial carcinoma was rarely identified histologically in patients with an AGC Pap test who were aged <50 years.…”

Section: Discussionsupporting

confidence: 93%

Significance of high‐risk HPV detection in women with atypical glandular cells on Pap testing: Analysis of 1857 cases from an academic institution

Patadji

Pradhan

Zhao

2016

Cancer Cytopathology

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To the authors' knowledge, the current study is the largest follow-up study published to date regarding women with AGC cytology and HPV testing. The study data indicate that hrHPV testing is useful for predicting the risk of high-grade cervical neoplasia in women with AGC, but has no significant value in evaluating the risk of endometrial carcinoma. The combination of cytology, hrHPV testing, and patient age can significantly aid in the appropriate management of these individuals. Cancer Cytopathol 2017;125:205-211. © 2016 American Cancer Society.

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Section: Discussionsupporting

confidence: 93%

Significance of high‐risk HPV detection in women with atypical glandular cells on Pap testing: Analysis of 1857 cases from an academic institution

Patadji

Pradhan

Zhao

2016

Cancer Cytopathology

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“…However, there is no cost‐effective screening tool for endometrial cancers currently. We recently noted that 179 cases (44.2%) had abnormal glandular endometrial cells within the 5 months before the histologic diagnosis for 405 cases of endometrial carcinomas, and this indicates that the Pap test may play a role in the detection of endometrial carcinoma, especially for those with cervical involvement, lymphovascular invasion, and/or an advanced stage . In the current study, endometrial carcinoma, complex atypical hyperplasia, or both were found in 202 of 3007 women (6.7%) with AGC Pap results, and the rate was higher in women who were 50 years old or older with AGC (15.8%) and AMC cytology results (30.0%).…”

Section: Discussionsupporting

confidence: 46%

Clinical significance of atypical glandular cells in Pap tests: An analysis of more than 3000 cases at a large academic women's center

Pradhan

Ocque

et al. 2016

Cancer Cytopathology

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BACKGROUND The interpretation of atypical glandular cells (AGC) in Papanicolaou (Pap) tests and screening for glandular neoplasia remain challenging. METHODS Pap tests with an AGC interpretation from January 2008 to December 2013 were retrieved from a pathology database, and cases with histologic follow‐up within 1 year were included in the study. RESULTS There were 589,830 Pap tests during the study period, and 3709 cases (0.6%) were reported as AGC, which included the following: AGC, not otherwise specified (52.0%); atypical endocervical cells (28.0%); and other categories. There were 3007 cases (81.1%) with histologic follow‐up results within 1 year. Cervical intraepithelial neoplasia 2/3 (CIN2/3), cervical adenocarcinoma in situ (AIS)/adenocarcinoma, and endometrial carcinoma were identified in 5.6%, 1.9%, and 5.5% of cases, respectively. Glandular neoplasia was more likely to be identified in cases with pure AGC subcategories than cases with AGC and squamous abnormalities. Endometrial neoplasia was more likely to be identified in cases with atypical endometrial cells than other categories. Overall, the most common severe abnormality on histologic follow‐up was CIN2/3. Although CIN2/3 was the most common severe lesion in patients younger than 30 years (10.0%) and in patients aged 30 to 49 years (6.4%), endometrial carcinoma was the most common lesion in women who were 50 years old or older (13.7%). Endocervical glandular lesions (AIS and adenocarcinoma) occurred in only 1.9% of women. CONCLUSIONS AGC subtypes and ages significantly affect histological follow‐up results; 90.5% of cases with carcinoma on histologic follow‐up were either endometrial or metastatic carcinoma. This study supports the recommendation that women with AGC Pap test results should be followed up with both endocervical and endometrial sampling. Cancer Cytopathol 2016;124:589‐95. © 2016 American Cancer Society.

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“…The value of Papanicolaou tests for detection of EC was evaluated in several retrospective studies 3,12–15 . This current research supports the findings of low sensitivity of Papanicolaou tests for detection of EC.…”

Section: Discussionsupporting

confidence: 83%

Does cervicovaginal cytology have a role in the diagnosis and surveillance of endometrial adenocarcinoma?

Kılıç

Yetimalar

Bezircioglu

et al. 2020

Diagnostic Cytopathology

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Objective To examine the role of cervicovaginal cytology in diagnoses and surveillance of the patients with endometrial carcinoma (EC). Methods Patients who underwent EC surgery that included a follow‐up were reviewed retrospectively. The cohort was limited to the patients who had an available cervical cytology result within 12 months before the primary surgery took place. The glandular abnormalities were classified in the following subclassifications: “atypical glandular cells” (AGC)‐not otherwise specified (NOS), AGC‐favor neoplasia, endocervical AIS, and adenocarcinoma. Results A total of 411 patients were eligible for the study. The cervical cytology was found to be normal and recorded as negative for intraepithelial lesion or malignancy in 368 (89.5%) patients. In 43 (10.5%) patients, cervical cytology was interpreted as: AGC‐NOS (n = 11), AGC‐FN (n = 7), adenocarcinoma (n = 20), malignant epithelial tumor (n = 3), and squamous carcinoma (n = 2). During the follow‐up, recurrence was observed in 53 (12.9%) patients. Among six isolated vaginal cuff recurrences, two of the cases presented with malignant cytology, and the additional four cases were suspected during clinical examination. Among women with recurrence (n = 53), there were malignant cytological findings in four of the patients. In the whole population (n = 411), there were four other abnormal cytological findings detected within the surveillance. These four cytology results were nonmalignant and no recurrence was identified. Conclusion There is no significant clinical advantage of cervicovaginal cytology testing before diagnosis or during the surveillance of EC.

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The Value of the ThinPrep Test for Endometrial Carcinoma Diagnosis: A Large Study Cohort from an Academic Medical Center

Cited by 9 publications

References 0 publications

Significance of high‐risk HPV detection in women with atypical glandular cells on Pap testing: Analysis of 1857 cases from an academic institution

Significance of high‐risk HPV detection in women with atypical glandular cells on Pap testing: Analysis of 1857 cases from an academic institution

Clinical significance of atypical glandular cells in Pap tests: An analysis of more than 3000 cases at a large academic women's center

Does cervicovaginal cytology have a role in the diagnosis and surveillance of endometrial adenocarcinoma?

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